The inventors have developed methods for creating tannin-chitosan composite thin-films incorporating active pharmaceutical ingredients, including psilocybin (a psychedelic) and biosimilars (melatonin ...
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An active microneedle array and method are provided for penetrating an outer layer of an epidermis. The active microneedle array includes a base having first and second sides. The first side of the ba...
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Axial stress or similar properties in a stressed connective tissue may be assessed during surgery by excitation of the ligament to create a shear wave allowing measurement of the shear wave velocity w...
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Various aspects of the present disclosure characterize apparatuses and/or methods as may be implemented with a variety of prosthetic components and applications. As may be consistent with one or more ...
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A bone stent facilitates bone fixation via interior contact, as may be useful for flexible entry into a sidewall of an elongated bone. As consistent with one or more embodiments, a stent includes prox...
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A wearable medical bandage is provided having an energy harvesting generator that harvests mechanical energy from the user's natural body and muscle motions to produce electrical energy. The electrica...
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Disclosed are formulations for providing an active agent. Formulations include a carrier including an active agent and mineral coated microparticles wherein an active agent is adsorbed to the mineral....
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Disclosed are formulations for providing a therapeutic bioactive polypeptide to injured tissue. Formulations include mineral coated microparticles wherein a polynucleotide is adsorbed to the mineral l...
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Described herein are hybrid nanoparticles that are exosomes loaded with one or more nanoparticle dendrimers. Also included are pharmaceutical compositions including the hybrid nanoparticles and method...
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Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonuclei...
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A “localizable” systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape o...
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An office chair that is ergonomically configured to allow for the coordination of stretches to the pectoralis minor muscle, trapezius muscle, and scalene muscles to open up the thoracic outlet, releas...
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Microorganisms comprising a maltose-inducible promoter and methods of use in producing biologics and introducing biologics to sites in a maltose-dependent manner. The microorganisms include a maltose-...
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Slippery liquid-infused porous surfaces (SLIPS) are an emerging class of materials with unique antifouling properties and applications ranging from biomedical device coatings and consumer products to ...
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Growth factor regulation is a key function of the extracellular matrix and critical for proper blood vessel growth and maturation during wound healing. In particular, blood vessel sprouting is essenti...
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Collagen is the most abundant protein in vertebrates, providing support to virtually every tissue including skin, bone and blood vessel. It is of critical importance in wound healing. Given its signi...
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Cancer treatment planning remains an ongoing challenge to oncologists and patients alike, with each cancer being genetically unique and requiring personalized approaches. Greater outcome success will ...
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"Orthobiologics" provides an improved method of treating fractures and other bone defects. This therapy employs inductive molecules, such as bone morphogenetic protein-2 or bone morphogeneti...
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Drills are commonly used during orthopedic surgery to place screws that allow fixation of fractured bones. One problem that surgeons face while drilling is the overlying soft tissue becoming entangled...
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Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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Wound healing is a complex and dynamic process of rebuilding skin and tissue. Chronic or impaired wounds result when tissues fail to progress through the necessary stages of healing. This is a signifi...
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Chitosan is a soluble biopolymer derived from chitin, which is a structural element in the shell of marine arthropods.  Chitosan is used in water processing and agriculture.  It also is used...
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A fracture requiring orthopedic treatment occurs approximately every 14 seconds in the United States.  Musculoskeletal conditions cost an estimated $254 billion each year in the United States, an...
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Oral ingestion of pharmaceuticals currently is considered the safest, most convenient and most economical method of drug administration. However, oral delivery of many pharmaceuticals is not possible ...
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Many human diseases and conditions can be treated by implanting devices within the body. However, these devices may be rejected by the body’s immune system or “fouled” by the accumul...
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