Wisconsin Alumni Research Foundation

Technology

Treating Pulmonary Disorders with Artificial Lung Surfactant

Lung surfactant (LS) is a lipid-protein mixture that coats the internal surface of the lungs. It reduces the work of breathing by helping to keep air sacs open and stable. Deficient or dysfunctional L...
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Samuel Gellman, Shannon Stahl, Brendan Mowery, Annelise Barron, Michelle Dohm | P100038US02

Technology

Improved Photocatalyst for Reducing Small Molecules

The reduction of small molecules such as nitrogen and carbon dioxide is extremely difficult because one-electron reduction processes often involve high-energy intermediates. Nitrogen reduction usually...
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Robert Hamers, Di Zhu, Nigel Becknell | P120070US01

Technology

Neoglycorandomization and Digitoxin Analogs

Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and ...
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Jon Thorson, Joseph Langenhan | P04455US

Technology

One-Step Synthesis of Diazaphosphacycles

Phosphines have many commercial and industrial uses as attachments to rare earth metal catalysts, including specialized uses in asymmetric hydrogenation and other catalytic transformations. However, c...
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Clark Landis, Wiechang Jin, Jonathan Owen, Thomas Clark | P01419US

Technology

Chemical Synthesis of Reagents for Peptide Coupling

The Staudinger ligation method for synthesizing peptides requires phosphinothiol reagents that are not commercially available. The current method for making phosphinothiols is complicated (involving f...
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Ronald Raines, Laura Kiessling, Bradley Nilsson, Matthew Soellner, Yi He, Ronald Hinklin | P02304US

Technology

Producing Methyl Vinyl Ketone from Levulinic Acid

Levulinic acid is a biomass-derived compound that can be obtained inexpensively in high yields from a variety of waste cellulose-containing materials. It has been identified as a top biomass-derived c...
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James Dumesic, Ryan West | P09350US01

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