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54 Results for 'Synthesis'
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Technology
“Green” Catalytic Systems for Solvent-Free Alcohol Oxidations
Catalysts for organic chemical transformations, in particular those used for alcohol oxidations, are considered to be valuable commodities for the bulk, fine chemical as well as pharmaceutical industr...
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Robert McGaff | T150040US03
Technology
Gemini Surfactant LLC Membranes from Thiol-Ene Polymerizations
Lyotropic liquid crystal (LLC) assemblies are useful for highly selective chemical separations, such as water desalination and selective ion-transporting membranes. Bicontinuous cubic LLC assemblies a...
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Mahesh Mahanthappa, James Jennings | P150015US01
Technology
Phosphine Ligands Made Cheaper, Better
Enantiomers are pairs of compounds that have the same chemical formula but different spatial structures (like your left and right hand, they are non-superimposable mirror images of each other). This i...
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Jennifer Schomaker, Robert Grigg, Ryan Van Hoveln | P130268US02
Technology
Selective Conversion of Lignin into Simple Aromatic Compounds
Lignin is a major component of non-edible biomass (15-30 percent by weight; 40 percent by energy). It is a cheap byproduct of pulp and biofuel production and is one of the few naturally occurring sour...
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Shannon Stahl, Alireza Rahimi | P130104US01
Technology
Crosslinkable Gemini Dicarboxylate Surfactant LLCs and Their Membranes
Aqueous lyotropic liquid crystal (LLC) assemblies are useful for highly selective chemical separations, such as water desalination and selective ion-transporting membranes. LLCs are formed in water wh...
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Mahesh Mahanthappa, Gregory Sorenson | P120048US02
Technology
Generating Medical Isotopes with Safer Vessel and Materials
Medical isotopes are valuable healthcare tools for patient imaging and disease treatment. Yet most radioisotopes used in medicine are produced in nuclear reactors, which are complex, generate high vol...
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Gregory Piefer, Thad Heltemes, Ross Radel, Eric Van Abel | P120047US01
Technology
Easier, More Flexible Synthesis of Therapeutic and Promising Compounds
Many pharmaceuticals and other biologically active molecules contain chemical sequences called triads that are challenging to prepare in the laboratory. Specifically, triads are three or more contiguo...
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Jennifer Schomaker, Luke Boralsky, John Hershberger, Jared Rigoli, Christopher Adams | P110299US02
Technology
Streamlined Scheduling for Large-Scale Chemical Production
In chemical manufacturing, a production system may receive and process raw materials in multiple steps, with each step or task associated with a certain procedure or tool. Ideally, each step is schedu...
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Christos Maravelias, Sara Velez, Arul Sundaramoorthy | P120218US01
Technology
Treating Pulmonary Disorders with Artificial Lung Surfactant
Lung surfactant (LS) is a lipid-protein mixture that coats the internal surface of the lungs. It reduces the work of breathing by helping to keep air sacs open and stable. Deficient or dysfunctional L...
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Samuel Gellman, Shannon Stahl, Brendan Mowery, Annelise Barron, Michelle Dohm | P100038US02
Technology
New Peptide-Mimicking Compounds for Anti-Cancer PET Imaging
Cancers cause about 15 percent of all human deaths worldwide, are not fully understood and defy efficient therapy. Early detection and treatment can improve survival rates and one promising strategy i...
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Weibo Cai, Hao Hong, Jianfeng Cai, Youhong Niu | P130010US02
Technology
Method to Produce Sorbic Acid and Pentadiene from Renewable Biostock
Sorbic acid has been used extensively as a preservative in a vast array of food. The benefits of sorbates as food preservatives are two-fold: sorbates inhibit a wide spectrum of bacteria, yeasts and m...
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James Dumesic, Mei Chia | P100264US01
Technology
Improved Photocatalyst for Reducing Small Molecules
The reduction of small molecules such as nitrogen and carbon dioxide is extremely difficult because one-electron reduction processes often involve high-energy intermediates. Nitrogen reduction usually...
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Robert Hamers, Di Zhu, Nigel Becknell | P120070US01
Technology
Diazaphosphacycles, Which Are Used to Catalyze Commercially Important Reactions, and Methods of Synthesis
Phosphines have many commercial and industrial uses as attachments to rare earth metal catalysts, including specialized uses in asymmetric hydrogenation and other catalytic transformations. Asymmetric...
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Clark Landis, Wiechang Jin, Jonathan Owen, Thomas Clark, Ryan Nelson | P03130US
Technology
Synthesis of Endoperoxide from a Diene and Molecular Oxygen in the Presence of a Photocatalyst
Endoperoxides are prominent structural features of several natural products with potent activity against malaria and various cancer cell lines. However, they are difficult to synthesize. The most stra...
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Tehshik Yoon, Michael Ischay, Jonathan Parrish | P100348US01
Technology
Pure, Cyclically-Constrained Gamma-Amino Acids for Medicine and Materials
Unnatural polymers that contain β- and γ-amino acids are known as "foldamers." These foldamers form long-lasting, predictable structures that are very stable and resistant to prot...
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Samuel Gellman, Li Guo, Michael Giuliano | P100030US02
Technology
Synthesis of Proteins and Peptides Selectively Modified by Sulfation, Phosphorylation or Glycosylation
The lack of methods to easily synthesize sufficient quantities of selectively modified peptides and proteins has hindered research on the biological functions and molecular interactions of side-chain ...
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Laura Kiessling, Travis Young | P02386US
Technology
Improved Asymmetric Hydroformylation of Therapeutics Using Novel Bisphosphines
Asymmetric synthesis is important in the pharmaceutical industry because frequently only one optically active isomer, or enantiomer, is therapeutically active. Therefore, it is often desirable to sele...
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Clark Landis, Thomas Clark, Jerzy Klosin | P04447US
Technology
Simple, Gentle and Chemoselective Method of Synthesizing Diazo Compounds
Diazo compounds, which have the general formula R2C=N2, are versatile intermediates in organic synthesis. They participate in a variety of thermal, photochemical and metal-catalyzed reactions. M...
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Ronald Raines, Eddie Myers | P08318US02
Technology
Traceless Staudinger Ligation for the Synthesis of Peptides and Proteins in Water
UW–Madison researchers previously developed a method of using traceless Staudinger ligation to chemically synthesize proteins (see WARF reference number P00315US). This method is based on ...
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Ronald Raines, Matthew Soellner, Annie Tam | P08350US02
Technology
Efficient Beta2-Amino Acid Synthesis Via Organocatalytic Aldehyde Aminomethylationlation
Beta amino acids are the basic building blocks of beta peptides, which have physiological applications, such as blocking human cytomegalovirus infection. Although some types of beta amino acids are re...
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Samuel Gellman, Yonggui Chi, William Pomerantz, Emily English, William Horne, Li Guo | P06230US
Technology
One-Step Synthesis of Diazaphosphacycles
Phosphines have many commercial and industrial uses as attachments to rare earth metal catalysts, including specialized uses in asymmetric hydrogenation and other catalytic transformations. However, c...
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Clark Landis, Wiechang Jin, Jonathan Owen, Thomas Clark | P01419US
Technology
Chemical Synthesis of Reagents for Peptide Coupling
The Staudinger ligation method for synthesizing peptides requires phosphinothiol reagents that are not commercially available. The current method for making phosphinothiols is complicated (involving f...
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Ronald Raines, Laura Kiessling, Bradley Nilsson, Matthew Soellner, Yi He, Ronald Hinklin | P02304US
Technology
Heterogeneous Protein Foldamers Containing Alpha, Beta and Gamma Amino Acids
Foldamers are synthetic protein oligomers with discrete and predictable folding properties akin to those of natural proteins. They provide molecular tools to investigate large-molecule interactions su...
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Samuel Gellman, Ahlke Hayen, Margaret Schmitt, Felix Ngassa | P02125US
Technology
Producing Methyl Vinyl Ketone from Levulinic Acid
Levulinic acid is a biomass-derived compound that can be obtained inexpensively in high yields from a variety of waste cellulose-containing materials. It has been identified as a top biomass-derived c...
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James Dumesic, Ryan West | P09350US01
Technology
Low-Temperature Process to Produce Hydrocarbons from Oxygenated Substrates, Including Sugars
Hydrocarbon feedstocks currently are extracted from petroleum reserves in the ground and combusted to generate energy. They are transported easily as liquids, but are non-renewable and their comb...
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Randy Cortright, James Dumesic | P02136US