Wisconsin Alumni Research Foundation

WARF PORTFOLIOS

WARF Accelerator Program Technologies

WARF Accelerator selects WARF’s most commercially promising technologies and provides expert assistance and funding to enable achievement of commercially significant milestones. WARF believes that these technologies are especially attractive opportunities for licensing.

Technologies

Integrated Capacitor, Inductor and Resistor for Use as a Power Converter Filter

High-power electrical equipment such as electrical motors are increasingly powered using alternating current (AC) synthesized using semiconductor devices. Desirably, the semiconductors are operated in...
P170329US01

Multi-Functional Matrix to Promote Wound Healing and for Other Biomedical Applications

Wound healing is a complex and dynamic process of rebuilding skin and tissue. Chronic or impaired wounds result when tissues fail to progress through the necessary stages of healing. This is a signifi...
P01328US

Full Coverage Spray and Drainage System for Orientation-independent Removal of High Heat Flux

Removal of heat from electronic circuitry is one of the limiting factors in the design and performance of most computer systems. One current method of heat removal involves using a cone-shaped spray t...
P04140US

Improved Sensor Enables Sensitive Detection of Large Molecules in Mass Spectrometry

Mass spectrometry is a highly selective and quantitative technique that is widely used to determine the chemical composition of a sample. Applications of this analytical tool include measuring isotope...
P05110US

TTNPB Analogs Useful for Preventing or Treating Cancer

Retinoic acid and a number of its analogs have shown some ability to prevent and treat cancer. One of the most potent is 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benz...
P05114US

Methods and Compositions for Treating Prostate Cancer Using DNA Vaccines

Prostate cancer is a significant health risk for men over the age of 50 and currently is a pervasive health threat with as many as 200,000 new cases diagnosed each year in the US alone. At presen...
P05235US

Method for Improving Performance in a Sparse Multipath Environment Using Reconfigurable Arrays

The most salient feature of wireless communication channels is signal propagation over multiple scattering paths. Although this so-called multipath signal propagation leads to undesirable signal fadin...
P06176US

Robust and Improved Surfaces for Biological Microarrays That Reduce Nonspecific Binding

Biological microarrays are valuable tools that enable the parallel analysis of thousands of different analytes. However, one of the chief problems with existing protein microarrays is the nonspecific ...
P07188US

Improved Methods for Producing Low-Cost Protein-Polysaccharide Conjugates for Use in Foods and Beverages

Protein-polysaccharide conjugates (PPCs) are useful as emulsifiers in foods and beverages.  Because the polysaccharide stabilizes the protein, such conjugates have superior functional properties,...
P08190US

Efficient, Lower Cost Chemical Transformation of Lignocellulosic Biomass into Fuels and Chemicals

Cellulosic biomass has tremendous potential as a renewable resource for the production of fuels and chemicals.  It is especially promising because it is inexpensive and readily available from cro...
P08210US

Post-Processing MRI Fat Suppression Method to Enhance Image Quality and Improve Medical Diagnostics

Magnetic resonance imaging (MRI) is a diagnostic imaging technique that is especially effective for soft tissues such as the brain and other organs. To produce an MR image, the patient is subjected to...
P08308US

Vertical Cavity Light Sources Based on Stacked Membranes

Improvements in technologies such as cell phones, laptops and small digital electronics are the result of the increasing capability of electronics and photonics. However, there is a continuing need fo...
P08398US

Efficient and Automated Analysis of Thin Structures to Enhance Engineering 3-D Modeling Software

Mechanical engineers commonly employ a software modeling tool called finite element analysis (FEA) to virtually simulate a design prior to physical prototyping.  In FEA, a three dimensional (3-D)...
P08425US

A Photopatternable Layer for Controlling Block Copolymer Microdomain Orientation

The lithographic process is one of the key enabling technologies of the digital electronics era.  Lithography allows hundreds of millions of components to be fabricated on a single chip with patt...
P09005US

An Injectable Nanovehicle for a Cancer Treatment Combination of Paclitaxel, Rapamycin and 17-AAG

Two-drug combinations of paclitaxel and rapamycin (an mTOR inhibitor) as well as paclitaxel and 17-AAG (an enhanced version of geldanamycin and Hsp90 inhibitor) have progressed into human clinical tri...
P090383US03

β-cyclodextrin Removes Off-Flavors from Soy Protein, Increases Flavor Stability

Although purified proteins are bland and lack flavor, they can influence flavor perception by directly interacting with flavor compounds or by acting on flavor precursors.  This can lead to the d...
P090393US02

Pipelined Lookup Grid Architecture (PLUG)–Fast, Cool and Flexible Network Processing

Computer networks function by connecting spatially separated computers with “links” – electrical conductors, fiber optics and radio waves.  The majority of network protocols wor...
P09094US

Improved Molecule Mass Detection Using Electron Field Emission from Kinetically Impacted Membranes

Mass spectrometry is a broadly applicable analysis tool for detecting and characterizing molecules and other chemical species, including complex mixtures of biomolecules such as peptides, proteins or ...
P09192US

Modular Peptide Binds to Biomaterials and Promotes New Bone Formation

Musculoskeletal conditions cost an estimated $254 billion each year in the United States, and bone and joint diseases account for half of all chronic conditions in adults over the age of 50. Current c...
P09202US

Liquid Crystal-Based Assay for Rapid and Precise Detection of Endotoxin in the Presence of Masking Agents

Bacterial contamination is a major risk in biologics manufacturing and the presence of endotoxin, an outer membrane component of Gram-negative bacteria, is vigorously tested for in protein and DNA/RNA...
P09241US02

SmartRE: A Framework for Coordinated Network-Wide Caching

The bandwidth of a computer network is a measure of the rate of data transfer.  Limits on bandwidth may result from physical limitations of the media as well as processing limitations.  Incr...
P09290US

High-Yielding Method for Converting Biomass to Fermentable Sugars for Biofuel Production

Lignocellulosic biomass is a very desirable feedstock for biofuel production.  If the fermentation process for lignocellulose could be optimized, conversion of this biomass could yield 25 to 50 b...
P09305US02

Fatty Acid-Producing Microbes for Generating Medium- and Long-Chain Hydrocarbons

New, renewable sources of transportation fuel are needed to meet continuing demand. While the main focus has been on biomass-derived gasoline alternatives such as ethanol and other short-chain alcohol...
P09329US02

Large-Area, Nanoperforated Graphene Materials for Semiconducting Applications

Recently, interest and research in graphene has grown rapidly due to its outstanding electrical properties. Graphene, a two-dimensional carbon-based material, has high tensile strength, stiffness, opt...
P100012US02

Microfluidic Device for Rapid Nucleic Acid Isolation and Purification

Extraction and isolation of nucleic acids from biological samples is an essential prerequisite for further amplification, detection and quantification of specific genetic sequences. The first step in ...
P100050US01

Prioritized Data Mapping to Recover High Usefulness Data for Improved Wireless Communications

Sophisticated wireless transceivers transmit digital data encoded into a physical signal such as a radio wave. The encoding process changes multiple bits making up a data unit into symbols that descri...
P100120US02

Improved Delivery of Rich Media Content over Wireless Networks

Rich, high quality media content is becoming increasingly available through the Internet. As a result, user expectation of accessing such content over wireless-enabled devices continues to grow. While...
P100121US02

Cranberry Variety Trade Named "Sundance," with Large Berry Size and Favorable Bud Set Traits

Cranberry is Wisconsin’s number one fruit crop. Wisconsin provides nearly 60 percent of the U.S. supply, and significant growth in demand, particularly for fruit for sweetened dried cranberries, is ...
P100154US01

Antenna-Based Power Generation with Nanoscale Rectifying Elements

“Rectennas” are antennas that can receive radio signals and rectify them to generate electrical power for wireless power transfer. Potential applications for rectennas range from large-sca...
P100171US01

Improving Biomass Conversion Efficiency by Modifying Lignin so Plant Cell Walls Are More Digestible and Fermentable

Lignocellulosic biomass is a very desirable feedstock for biofuel production. If the fermentation process for lignocellulose could be optimized, conversion of this biomass could yield 25 to 50 billion...
P100225US02

Transgenic Lignin Easier to Break Down for Biofuel

Lignocellulosic biomass is a very desirable feedstock for biofuel production. If the fermentation process could be optimized, conversion of this biomass could yield 25 to 50 billion gallons of ethanol...
P100281US02

Lignin from Transgenic Poplar Is Easier to Process

Lignin is an important plant cell wall component that provides structural support and vascular functions. It is one of the most abundant organic polymers on Earth, constituting about 30 percent of non...
P100281US03

High Power, High Efficiency Quantum Cascade Lasers with Reduced Electron Leakage

Quantum cascade lasers (QCLs) are made of layered semiconductor materials. The structures’ cores are composed of tens of stages, each of which consists of three regions: an electron injector, an...
P100284US01

New Method for Direct Patterning in Block Copolymer Lithography

Most microelectronic devices are fabricated using top-down processes such as photolithography. Current top-down processes face growing limitations as the demand for smaller scale applications increase...
P100296US02

Consumer-Friendly Test for Detecting Very Small Amounts of Bacteria or Other Cells

The presence of even low levels of spoilage or pathogenic microorganisms in various products like leftover food can be dangerous and possibly lethal. However, most methods for detecting pathogens invo...
P100326US02

Compounds to Treat Hyperlipidemia and Fatty Liver Disease

Hyperlipidemia is a condition strongly associated with obesity and is an independent risk factor for the development of coronary heart disease. To help combat hyperlipidemia, the pharmaceutical indust...
P110006US01

Microcellular Foamed Plastics with Reduced Cost and Improved Surface Quality

Microcellular injection molding is a process that produces lightweight and dimensionally stable plastic components while using fewer raw materials than standard injection molding techniques. The proce...
P110013US01

Hybrid Analog-Digital Transceiver for Enhanced Wireless Communications

The widespread use of wireless communication applications in daily life has resulted in an increased need for power and bandwidth efficiency in emerging wireless transceivers. Two recent technological...
P110040US01

Electrically-Small, Super-Resolving Antennas and Arrays

The rise of wireless technology use in daily life has increased the need for electrically-small antennas with performance levels that exceed conventional limits. An electrically-small antenna is an an...
P110043US01

Method for the Growth of Uniform 3-D Nanorod Networks

Nanotubes and nanowires are used extensively to tailor material properties. However, wide implementation of their extraordinary characteristics has been difficult due to their 1-D geometry and limited...
P110104US01

Unleashing Biomass Sugars Using Bromine Salt

Methods to produce bioethanol from cornstarch or sugarcane are inadequate to meet the global demand for renewable fuels. To be sustainable, biofuel production should rely on abundant, cheap, inedible ...
P110209US02

GMP Protein Burns Fat, Boosts Bone Strength in Women

Bone mineral loss is a pervasive and potentially devastating consequence of aging. Post-menopausal women are at special risk for the fractures, fragility and debilitations linked to osteoporosis.
P110272US03

Enhanced Biomass Digestion with Wood Wasp Bacteria

Plant biomass represents a vast and renewable source of energy. However, harnessing this energy requires breaking down tough lignin and cellulose cell walls. In nature, certain microbes can deconstruc...
P110314US03

Patch for Delivering Therapeutic Cells into Heart

Throughout a person’s lifetime the heart undergoes slow cellular turnover. This steady regeneration is critical to maintaining healthy cardiac function from birth to old age. The heart’s a...
P110346US02

High-Symmetry, Bicontinuous Lyotropic Liquid Crystals with Percolating Nanoscale Domains

Liquid crystals, soft materials comprised of assemblies of organic molecules that exhibit long-range order at the five to 100 nanometer length scale, find widespread application in consumer goods rang...
P120009US01

Hibiscus Cannabinus Gene Discovery to Enable Altered Plant Lignin

Plant cell wall utilization in a variety of natural and industrial processes is hampered by the lignin component. To make lignin easier to degrade, Wisconsin researchers discovered how chemically reac...
P120103WO01

Natural Feed Additive Combats Gastrointestinal Infection in Livestock and Poultry

Reaping billion dollar losses every year, coccidiosis is a common protozoan infection of agricultural animals that targets the digestive system. Its symptoms include weight loss, diarrhea and suppress...
P120128US01

Electrically Small, Super-Directive Antennas Inspired by Insect Anatomy

Antennas that are electrically small, those with dimensions relatively diminutive compared to the size of the wavelengths they radiate, are integral to radio engineering, from wireless garage door ope...
P120184US01

One- and Two-Phase Conversion of Biomass to Furfural

Exploiting the energy potential of biomass high in cellulose and lignin—including grasses, shrubs, husks, bark, yard and mill offal not readily digestible by humans—offers a vast and renew...
P120195US01

Sustainable Organic Aerogels for Insulation

Aerogels are the world’s lightest solid materials made by the removal of liquid from gels. Such materials may contain up to 99 percent air and combine unique properties like high porousness and exce...
P120283US03

New Framework Helps Compose and Scale Middlebox Software Modules for Cloud Computing

Cloud computing is an emerging model for the delivery and consumption of information technology (IT) resources. Infrastructure-as-a-service cloud providers deliver virtual servers along with network c...
P120286US01

Enzyme Aids Intranasal Drug Delivery

Currently, delivering drugs directly into the brain requires invasive surgery. This is because a tight cellular layer called the blood-brain barrier (BBB) not only prevents harmful substances from ent...
P120322US02

Better Biomass Conversion with Recyclable GVL Solvent

To recover useful carbohydrates locked in biomass, molecular bonds must be broken while avoiding further reaction of the resulting glucose and xylose sugars. This is a challenge because glucose can de...
P130123US01

Inhibiting Storage Browning in Cheese

For 800 years Parmesan has been one of the most sought-after cheeses and today supports a billion dollar market. Parmesan is susceptible to an unappealing browning effect that is not fully understood ...
P130152US01

Sharper Stereotactic Radiosurgery

Radiosurgery is a non-invasive procedure that degrades tumors and other unhealthy tissue with high-energy beams of radiation. To spare surrounding tissue, it is critical that irradiation is precisely ...
P130196US01

Stretchable Transistors Using Carbon Nanotube Film

Stretchable electronics have many potential applications such as implantable biosensors, wearable devices and flexible displays. Yet critical components like transistors are still based on silicon. Ef...
P130386US01

Block Copolymers for Sub-10 Nanometer Lithography

Block copolymer (BCP) lithography is one of the most powerful technologies of the digital electronics era, allowing millions of nanoscale components to be fabricated on a single chip.

BCPs ar...
P140025US01

Superabsorbent, Sustainable Aerogels

Aerogels are the world’s lightest solid materials made by removing liquid from gels. Such materials may contain up to 99 percent air and have special properties like high porosity and absorption. P140038US02

Microbes Produce High Yields of Fatty Alcohols from Glucose

Fatty alcohols are used in detergents, emulsifiers, lubricants and personal care items. More than 1.3 million tons of fatty alcohols are used worldwide each year, representing a $3 billion market.
...
P140076US02

Encrypting Intellectual Property Cores

System-on-Chip (SoC) is a technique for designing complex integrated circuits using circuit ‘building blocks’ developed by different companies. Electronic files describing each building block are...
P140095US01

Minimally Invasive Microwave Ablation Antennas

Microwave ablation is a minimally invasive method for treating cancer, especially solid tumors. The method uses an interstitial antenna that heats tissue with microwave energy.

These antennas...
P140132US01

Superior Nanotube Film for High Performance Field Effect Transistors

Single-walled carbon nanotubes (SWCNTs) are key building blocks for nanoscale technologies given their interesting physical and chemical properties. SWCNTs are especially promising for high speed and ...
P140200US01

Combined Capacitor/Inductor Reduces Circuit Bulk

Inductors and capacitors are fundamental building blocks in many electrical devices and provide energy storage. Inductors store energy in the form of a magnetic field in the vicinity of a coiled condu...
P140216US01

Controlling Superconducting Quantum Circuits

In the exciting field of quantum computation, the performance of quantum bits (‘qubits’) is advancing rapidly. Among several implementations currently being pursued, superconductor-based circuits ...
P140260US01

Combatting Parasitic Worms in Livestock and Other Animals

The United States cattle industry includes about 40 million beef and dairy cows. At some point in their lives the majority of calves will graze and be exposed to parasitic worms known as helminthes. W...
P140283US01

Hybrid Heterostructure Light-Emitting Devices

Conventional light-emitting diodes (LEDs) are made of an upper ‘p-type’ layer, a middle ‘intrinsic region’ and a bottom ‘n-type’ layer. Such layered structures are called PIN diodes. Curre...
P140343US01

Improved CT Imaging with Multisource X-Ray Tube

Computed tomography (CT) provides rapid, noninvasive imaging at high resolution. Conventional CT systems include a gantry, one or two X-ray tubes and a detector assembly that rotate together around a ...
P140374US01

Memory Processing Unit Boosts Performance, Cuts Energy Usage

A significant amount of time and power is spent waiting for processors to retrieve instructions and data from distant levels of memory. One approach to mitigate access latency (delay) is to use a thre...
P140414US01

Synthesizing Natural Products to Treat High Blood Cholesterol

Indole is one of the most abundant heterocycles in pharmaceuticals and bioactive natural products, such as indometacin, a non-steroid anti-inflammatory drug, and vincristine, a natural product used to...
P150023US03

New Discoveries in Biological Safety: Liquid Crystal Detection of Hazardous Environmental Products

Volatile organic compounds (VOCs) are found in common household and industrial products. These toxic and/or carcinogenic compounds such as toluene, benzene and styrene are difficult to detect and pers...
P150037US02

Middlebox Scaling for the Cloud

As data is shuffled around in computer networks, important components called middleboxes (also called network functions or NFs) examine and modify network traffic to meet security requirements, perfor...
P150073US01

Polymer Coating for Cell Culture Substrates

A stem cell’s microenvironment plays a key role in regulating its behavior (e.g., adhesion, migration, proliferation and differentiation). A variety of templates have been used to study stem cell be...
P150079US01

New Compounds for Treating High Blood Cholesterol and More

Indole is one of the most abundant heterocycles in pharmaceuticals and bioactive natural products, such as indometacin, a non-steroid anti-inflammatory drug, and vincristine, a natural product used to...
P150140US02

Effective and Robust Method of T Cell Expansion and Activation

T cell based immunotherapy is a rapidly growing field that has experienced impressive clinical anti-cancer successes in the last few years. In particular, it is now possible to generate human T cells ...
P150198US02

3-D Printer for High Quality, Large-Scale Metal Parts

Despite recent advances in additive manufacturing, especially rapid plastic prototyping, there is still a need for better 3-D metal printers. Current techniques are relatively slow and not up to the t...
P150236US01

Slippery Antifouling Surfaces with Health, Environmental and Consumer Applications

Slippery liquid-infused porous surfaces (SLIPS) are an emerging class of materials with unique properties. They possess useful antifouling characteristics, meaning they prevent other matter or organis...
P150342US02

Non-Invasive Device for Measuring Stress in Tendons, Ligaments and Muscles

Measuring muscle and ligament stress is crucial in rehabilitative medicine and medical research. Using this data, clinicians and researchers can develop treatment plans and new technologies to improve...
P150362US01

Boron- and Nitride-Containing Catalysts for Oxidative Dehydrogenation of Small Alkanes and Oxidative Coupling of Methane

C3 and C4 olefins such as propene are key starting materials in the plastics and chemical industry. The main method for producing these critical building blocks is a petrochemica...
P150387US02

Preen Oil: The Nutritional Approach to Chronic Inflammation

Low-grade chronic inflammation underpins many diseases affecting both human and animal health. It remains largely undiagnosed and undertreated worldwide.

Preen oil, secreted by the uropygial...
P160017US01

Rapid MRI Gradient Calibration Using Single-Point Imaging

In MRI, gradient distortions can cause image artifacts such as blurriness, ringing and phase error. Certain MRI techniques are more prone to the problem. In particular, gradient distortion is perhaps ...
P160026US01

Perovskites as Ultralow Work Function Cathode Materials

Electron emission cathode materials are found in high power electron beam devices used in defense, scientific research and communications applications as well as thermionic energy conversion technolog...
P160033US02

Genetic Testing for Acquired Peripheral Neuropathy in Dogs

Peripheral neuropathies are a diverse group of diseases marked by degeneration of the peripheral nervous system. These diseases affect both humans and animals. In humans, the most common form is Charc...
P160048US02

Location-Aware Communication System for Mobile Devices

The proliferation of LEDs for ambient lighting is driving smart lighting technologies. Visible light communication (VLC) is an emerging technology that uses LEDs as transmitters and light sensors (e.g...
P160080US01

Green Method for Producing 1,5-Pentanediol Slashes Catalyst Cost 10,000-fold

Commercial interest in the production of commodity chemicals from renewable sources continues to surge. Among these chemicals, α,ω-diols are particularly attractive because of the high market prices...
P160103US01

Inverter for Common Mode Voltage Cancellation

In a drive system, a voltage source inverter (VSI) may be used to transfer real power from a DC power source to an AC load. Conventional VSIs consist of two or three phase-legs, each of which is a ser...
P160142US01

Research Tool for Protein Conformation Analysis

The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
P160180US02

Point-of-Care Obstetrical Imaging for Minimally or Untrained Birth Attendants

Advance warning of some of the main causes of maternal and/or neonatal problems can prevent death and long term health complications. These causes include bleeding (e.g., from placenta previa over the...
P160185US02

“Green” Triboelectric Power Boards Turn Footsteps into Electricity and More

Mechanical energy takes many forms in the environment, from ambient vibrations to individual footsteps. It represents a sustainable and largely untapped energy source that could be harnessed to power ...
P160323US01

Matrix Processor with Localized Memory to Increase Data Throughput

Matrix calculations such as matrix multiplication are foundational to a wide range of emerging computer applications such as machine learning and image processing. Matrix calculations cannot be fully ...
P160414US01

Indoor Navigation System for Mobile Devices

Airport travelers, retail shoppers and hospital visitors are a few of the millions of people who could benefit from improved indoor positioning. Yet even after decades of research, a simple and robust...
P170079US01

Rechargeable Desalination Battery

Access to fresh water is a pressing geopolitical issue and technological challenge. Desalination is a potentially viable solution considering the abundance of seawater on Earth. While reverse osmosis ...
P170083US01

Vanadium Dioxide Design Solution for Ultrafast Switches

The unique properties of vanadium dioxide (VO2) mean it could one day outperform silicon and enable next-generation, ultralow-power devices. A key advantage of this material is that above 3...
P170254US01

ECMO Simulation Device for Hands-On Training and Improved Patient Outcomes

Extracorporeal membrane oxygenation (ECMO) is a technique for providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to provide an adequate amount of gas excha...
P190202US01

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