Technologies
PDF


WARF: P090383US03

An Injectable Nanovehicle for a Cancer Treatment Combination of Paclitaxel, Rapamycin and 17-AAG


INVENTORS -

Glen Kwon

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a composition of the synergistic anticancer agents rapamycin, paclitaxel and 17-AAG, encapsulated and solubilized by nontoxic, nanoscale PEG-b-PLA micelles.
OVERVIEWTwo-drug combinations of paclitaxel and rapamycin (an mTOR inhibitor) as well as paclitaxel and 17-AAG (an enhanced version of geldanamycin and Hsp90 inhibitor) have progressed into human clinical trials for cancer therapy. UW-Madison researchers have discovered that paclitaxel, rapamycin and 17-AAG exert synergistic anticancer activity against breast cancer cells. They also have discovered that nontoxic, nanoscale poly(ethylene glycol)-block-poly(lactic acid), or PEG-b-PLA, micelles surprisingly can take up all three cancer drugs, enabling the simple, safe, sterile and synergistic delivery of this three-drug combination, as opposed to conventional vehicles that are toxic, incompatible and require sequential drug administration.
THE INVENTIONA UW-Madison inventor has developed a novel, nontoxic nanoformulation of multiple anticancer agents.  This nanoformulation consists of rapamycin, paclitaxel and 17-AAG, encapsulated by safe PEG-b-PLA micelles. 

These polymeric micelles can be used to safely and effectively deliver multiple active agents, including therapeutics that are poorly soluble in water, enabling the simple, sterile and synergistic delivery of paclitaxel, rapamycin and 17-AAG.  The combination of paclitaxel, rapamycin and 17-AAG is particularly effective because it targets the PI3-AKT-mTOR pathway, a common deregulated pathway in cancer, leading to disruption at both AKT and mTOR.
APPLICATIONS
  • Cancer therapy using a nanocombination of paclitaxel, rapamycin and 17-AAG 
KEY BENEFITS
  • PEG-b-PLA micelles containing paclitaxel, rapamycin and 17-AAG are stable and remain soluble in water for 24 hours at room temperature.
  • PEG-b-PLA micelles are in Phase II clinical trials for paclitaxel alone and have proven to be safe after IV infusion in humans.
  • Paclitaxel, rapamycin and 17-AAG can be incorporated together into individual PEG-b-PLA micelles or incorporated individually into PEG-b-PLA micelles, which can be administered concurrently or sequentially.
  • Levels of paclitaxel, rapamycin and 17-AAG together in PEG-b-PLA micelles reach the level of each drug loaded individually in PEG-b-PLA micelles.
  • PEG-b-PLA micelles are safer than toxic excipients like Cremophor® EL or DMSO, enabling the use of higher drug doses for cancer therapy.
STAGE OF DEVELOPMENTPaclitaxel, rapamycin and 17-AAG solubilized together in PEG-b-PLA micelles have been shown to exert synergistic activity against breast cancer cells in vitro. They can be administered to mice at surprisingly high doses (60, 30 and 60 mg/kg, respectively, on days 0, 4 and 8) with low acute toxicity (<15% body weight change and no deaths).

The development of this technology was supported by WARF Accelerator. WARF Accelerator selects WARF's most commercially promising technologies and provides expert assistance and funding to enable achievement of commercially significant milestones. WARF believes that these technologies are especially attractive opportunities for licensing.
ADDITIONAL INFORMATION
For More Information About the Inventors
Publications
  • Shin H.C., Alani A.W., Rao D.A., Rockich N.C. and Kwon G.S. 2009. Multi-Drug Loaded Polymeric Micelles for Simultaneous Delivery of Poorly Soluble Anticancer Drugs. J. Control. Release 140, 294-300.
Contact Information
For current licensing status, please contact Rafael Diaz at rdiaz@warf.org or 608-960-9847.
The WARF Advantage

WARF: A Leader in Technology Transfer Since 1925
Since its founding as a private, nonprofit affiliate of the University of Wisconsin–Madison, WARF has provided patent and licensing services to UW–Madison and worked with commercial partners to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.

The University of Wisconsin and WARF –
A Single Location to Accelerate Translational Development of New Drugs

UW–Madison has the integrative capabilities to complete many key components of the drug development cycle, from discovery through clinical trials. As one of the top research universities in the world, and one of the two best-funded universities for research in the country, UW–Madison offers state-of-the-art facilities unmatched by most public universities.

These include the Small Molecule Screening Facility at the UW Comprehensive Cancer Center; the Zeeh Pharmaceutical Experiment Station, which provides consulting and laboratory services for developing formulations and studying solubility, stability and more; the Waisman Clinical Biomanufacturing Facility; the Wisconsin Institute for Medical Research, which provides UW–Madison with a complete translational research facility; and the innovative, interdisciplinary Wisconsin Institutes for Discovery, home to the private, nonprofit Morgridge Institute for Research and its public twin, WID, part of the university's graduate school. The highly qualified experts at these facilities are ready to work with you to create a library of candidates for drug development.