Wisconsin Alumni Research Foundation

Technology

Nanocapsule Delivery System for Ribonucleoproteins

With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
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Shaoqin Gong, Krishanu Saha, Guojun Chen, Amr Abdeen, Yuyuan Wang, Ruosen Xie | P170376US02

Technology

Reagents for Bioreversible Protein Esterification

Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Ronald Raines, Kalie Mix | P150262US03

Technology

Bioreversible Boronates Improve Drug Delivery

The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Ronald Raines, Thomas Smith | P150009US02

Technology

Enhancing Cell Penetration to Improve Drug Delivery

The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Ronald Raines, Kristen Andersen | P150031US02

Technology

Thermogel for Combination Drug Delivery

As cancer research progresses, it is evident that single drug formulations only provide limited success. Developing combination therapies would greatly benefit patients, especially those who must fol...
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Glen Kwon, Hyunah Cho | P130338US03

Technology

Improving Drug Delivery with Boronic Acids

The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Ronald Raines, Gregory Ellis, Michael Palte | P110315US02

Technology

Microfluidic Device for Drug Delivery

Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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David Beebe, Michael MacDonald, David Eddington, Glennys Mensing | P04240US

WARF