The UW inventors and collaborators developed a new modality of directly “painting” drug-loaded unimolecular micelles (UM) to the adventitia thus obviating the need for a hydrogel. To render tissue...
Learn More

This invention from UW Madison researchers presents recombinant microorganisms and methods of using same. The recombinant microorganisms include one or more modifications that reduce the expression an...
Learn More

The present invention from UW Madison researchers is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are part...
Learn More

UW-Madison researchers along with collaborators engineered a multimodal nanocluster drug delivery particle for treating restenosis. The researchers formed the nanocluster by self-assembly of H40-polyl...
Learn More

UW-Madison researchers have discovered rearrangement sequences that can be used to engineer rAAV vectors so that they may assemble larger therapeutic transgenes. Using forward and reverse primers that...
Learn More

UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
Learn More

UW-Madison researchers have identified new antibodies and related single-chain antibody fragments (scFvs) that bind and transport across the brain vasculature. These promising antibodies were discover...
Learn More

UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
Learn More

UW-Madison researchers have developed a novel lipid nanoparticle for delivering biomolecules. The researchers designed the lipopeptide-based nanoparticle for efficient delivery of various biomolecules...
Learn More

UW-Madison researchers have developed a novel platform that can selectively and sustainably scavenge ROS in inflamed colon tissues while also improving probiotic delivery for gut microbiota homeostasi...
Learn More

UW-Madison researchers have developed a novel, cross-species antibody to fibroblast activation protein (FAP). The researchers identified the antibody through screening of a phage display library. That...
Learn More

Fibroblast Activation Protein (FAP) is expressed in 90% of all solid tumors, making it an attractive target in cancer. Current small molecules targeting FAP clear from the system too rapidly, and FAP-...
Learn More

UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small...
Learn More

UW-Madison researchers have developed approaches to improve recombinant AAV gene therapy vectors (rAAV) therapies by improving their expression in target cells. The inventors have discovered that the ...
Learn More

UW-Madison researchers have discovered a regulatory system that controls the activation of certain prophages in the genome of Lactobacillus reuteri, which result in the bursting of the L. reuteri cell...
Learn More

UW-Madison researchers have developed antibodies or antigen binding fragments thereof (i.e., single chain variable fragment (scFv)) that specifically bind to the blood brain barrier (BBB). The researc...
Learn More

UW-Madison researchers have developed a dendron-micelle (DM) nanoparticle platform that can be used for combination therapy in the treatment of interstitial lung disease (ILD), including idiopathic pu...
Learn More

UW-Madison researchers have identified new antibodies and related single-chain antibody fragments (scFvs) that bind and transport across the brain vasculature. These promising antibodies were discover...
Learn More

UW researchers have developed a polymeric nanoparticle to package and deliver a CRISPR/Cas protein/guide RNA complex and, optionally, a single stranded DNA repair template into cells for gene therapy....
Learn More

Two UW-Madison researchers have developed a sequential coating strategy to improve the efficacy of probiotics used in the treatment of IBD.  The probiotic is first coated with a tannic acid (TA) laye...
Learn More

UW-Madison researchers successfully developed and demonstrated improved mRNA stabilization techniques that leverage mineral coatings. In short, the inventors stabilized mRNA complexes on mineral coate...
Learn More

UW-Madison researchers have developed a retinal organoid model system for evaluating therapies that target genetic mutations. The inventors have discovered that genetic modifications that compromise t...
Learn More

Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
Learn More

Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
Learn More

UW-Madison researchers have developed a nanoparticle-based platform comprising targeting agents (i.e., tumor selective peptides) and active agents (e.g., immuno- and chemo-drugs).  The nanoparticles ...
Learn More