Technologies
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WARF: P150020US02

Field Test for Mycobacterial Infections


INVENTORS -

Adel Talaat

The Wisconsin Alumni Research Foundation is seeking commercial partners interested in developing a method for the early diagnosis and differentiation of mycobacterial infections in livestock.
OVERVIEWMycobacterial infections cause major health problems for people and animals, including human tuberculosis, bovine tuberculosis and Johne’s disease. Johne’s disease (or paratuberculosis) afflicts 91 percent of dairy herds in the U.S. and costs the industry an estimated $500 million every year. Bovine tuberculosis, which is caused by a different subspecies of the bacteria, is endemic in dairy herds and a threat to wildlife in many developed countries including the U.S., U.K. and Australia.

Current diagnostic tests miss the early stages of infection and cannot differentiate infected from vaccinated animals (the DIVA principle). Early and reliable detection is imperative to control the infection in herds.
THE INVENTIONA UW–Madison researcher has identified a set of biomarkers that can indicate whether a mammal is vaccinated or infected, as well as the type of infection (bovine tuberculosis or Johne’s disease).
BUSINESS OPPORTUNITYThe global animal diagnostics market reached $1.5 billion in sales in 2011, while the U.S. veterinary services market exceeded $31 billion in 2013. Numerous companies offer Johne’s disease testing services/kits. However, a major downside of conventional diagnostics is that vaccinated animals will test positive.

Also, in spite of the economic losses caused by Johne’s disease, a study has shown that farmers’ incentives to manage and control the disease are relatively low. The poor sensitivity of available tests seems to be partly responsible for this, and more sensitive diagnostics could change farmers’ economic calculations.
APPLICATIONS
  • Diagnostic methods that can identify and distinguish between animals that have been infected and those that have been vaccinated, as well as clarify the nature of the infection
  • Kits for farmers/veterinarians
KEY BENEFITS
  • Early stage detection
  • Could be used in the field (point-of-care assay)
  • Distinguishes between vaccination and infection
  • Identifies type of infection (bovine tuberculosis or Johne’s disease)
  • Could encourage the adoption of new vaccines
STAGE OF DEVELOPMENTThe researcher has established a set of markers that can be used for the early diagnosis of Johne’s disease in ruminants (e.g., cattle, goats, sheep and camels).

The development of this technology was supported by the WARF Accelerator Program. The Accelerator Program selects WARF’s most commercially promising technologies and provides expert assistance and funding to enable achievement of commercially significant milestones. WARF believes that these technologies are especially attractive opportunities for licensing.
Contact Information
For current licensing status, please contact Emily Bauer at emily@warf.org or 608-960-9842.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.