Detection of genetic aberrations using nucleic acids as biomarkers can be a powerful strategy for disease diagnosis and progression monitoring; however, the high heterogeneity of cells within a patien...
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UW-Madison researchers have developed mass spectrometry (MS) compatible nanoparticles for the selective capture and enrichment of low abundance proteins. The surface of superparamagnetic nanoparticles...
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Sjögren’s syndrome is one of the most common systemic rheumatic diseases, affecting an estimated 4 million Americans. In roughly half of patients, this disorder occurs in the presence of another au...
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UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.   
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UW – Madison researchers have determined that SARS-CoV-2 infection induces antibodies against both structural and non-structural proteins and they identified epitopes in the SARS-CoV-2 membrane ...
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The current gold standard method for COVID-19 testing is a multi-step protocol 25 involving RNA extraction using column-based or magnetic bead-based methods, followed by RT-qPCR-based detection of the...
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Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet.  The sample collection system may be automated to collect sample urine from a...
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Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and p...
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The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine recipients, ...
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Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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The disclosure relates to laboratory and bioinformatics methods for isolating, detecting, and characterizing microbes in biological samples using metagenomic approaches.
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Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
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It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Mycobacterial infections cause major health problems for people and animals, including human tuberculosis, bovine tuberculosis and Johne’s disease. Johne’s disease (or paratuberculosis) afflicts 9...
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Fungal infections such as aspergillosis and Valley Fever can be life threatening, particularly in immune-compromised patients. These patients are vulnerable to fungal strains that flourish in hospital...
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Blastomyces dermatitidis is a soil fungus found throughout the world, and is especially prevalent in the river valleys and Great Lakes region of the United States. If spores are inhaled, blastomycosis...
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Mengovirus is a picornavirus that causes encephalomyocarditis in humans and other animals.
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Botulinum neurotoxins produced by Clostridium botulinum are the most potent toxins known. Because of the threat of bio-terrorism, sensitive methods for detecting botulinum neurotoxin are needed; howev...
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The NADH cytochrome b5 reductase/cytochrome b5 system can transfer electrons to other enzymes, including those involved in the metabolism of fatty acids, toxins and drugs. In the past, NADH cytochrome...
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La Crosse virus is an etiologic agent for childhood encephalitis in North America. Structurally, the nucleocapsid of this virus is enclosed by a host-derived lipid envelope holding two virion glycopro...
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Botulinum toxin is used for cosmetic procedures and to treat neurological disorders from spasmodic disorders to chronic pain syndromes.  The most widely used form of botulinum toxin is the seroty...
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Influenza is a major human disease caused by one of three types of influenza viruses. Type A viruses cause the most severe illnesses and are responsible for most epidemics; type B viruses generally ca...
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