UW-Madison researchers have developed a genetic rescue assay that discriminates the activities of wild type DDX41 from those of human myeloid malignancy-associated germline and somatic DDX41 mutants. ...
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Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Minimal Residual Disease (MRD) detection assays such as those used to detect the presence of cancer at early stages have largely relied on single nucleotide variant (SNV) detection in plasma DNA. Whil...
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UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method cons...
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Detection of genetic aberrations using nucleic acids as biomarkers can be a powerful strategy for disease diagnosis and progression monitoring; however, the high heterogeneity of cells within a patien...
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UW-Madison researchers have developed mass spectrometry (MS) compatible nanoparticles for the selective capture and enrichment of low abundance proteins. The surface of superparamagnetic nanoparticles...
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UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.   
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UW – Madison researchers have determined that SARS-CoV-2 infection induces antibodies against both structural and non-structural proteins and they identified epitopes in the SARS-CoV-2 membrane ...
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The current gold standard method for COVID-19 testing is a multi-step protocol 25 involving RNA extraction using column-based or magnetic bead-based methods, followed by RT-qPCR-based detection of the...
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Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet.  The sample collection system may be automated to collect sample urine from a...
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Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and p...
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The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine recipients, ...
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Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
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It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Mycobacterial infections cause major health problems for people and animals, including human tuberculosis, bovine tuberculosis and Johne’s disease. Johne’s disease (or paratuberculosis) afflicts 9...
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Fungal infections such as aspergillosis and Valley Fever can be life threatening, particularly in immune-compromised patients. These patients are vulnerable to fungal strains that flourish in hospital...
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Blastomyces dermatitidis is a soil fungus found throughout the world, and is especially prevalent in the river valleys and Great Lakes region of the United States. If spores are inhaled, blastomycosis...
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Mengovirus is a picornavirus that causes encephalomyocarditis in humans and other animals.
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Botulinum neurotoxins produced by Clostridium botulinum are the most potent toxins known. Because of the threat of bio-terrorism, sensitive methods for detecting botulinum neurotoxin are needed; howev...
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The NADH cytochrome b5 reductase/cytochrome b5 system can transfer electrons to other enzymes, including those involved in the metabolism of fatty acids, toxins and drugs. In the past, NADH cytochrome...
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La Crosse virus is an etiologic agent for childhood encephalitis in North America. Structurally, the nucleocapsid of this virus is enclosed by a host-derived lipid envelope holding two virion glycopro...
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Botulinum toxin is used for cosmetic procedures and to treat neurological disorders from spasmodic disorders to chronic pain syndromes.  The most widely used form of botulinum toxin is the seroty...
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