UW-Madison researchers have developed a genetic rescue assay that discriminates the activities of wild type DDX41 from those of human myeloid malignancy-associated germline and somatic DDX41 mutants. ...
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Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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UW-Madison researchers have developed a novel, cross-species antibody to fibroblast activation protein (FAP). The researchers identified the antibody through screening of a phage display library. That...
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Rheumatoid factors (RFs) are antibodies that commonly develop in patients with rheumatoid arthritis (RA), an incurable autoimmune disease that affects ~1% of the population. RFs bind to IgG and other ...
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Minimal Residual Disease (MRD) detection assays such as those used to detect the presence of cancer at early stages have largely relied on single nucleotide variant (SNV) detection in plasma DNA. Whil...
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UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method cons...
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Staff at the Wisconsin State Laboratory of Hygiene have prepared influenza virus isolate A/Wisconsin/588/2019 (FR-1758), as part of their influenza surveillance work through the national CDC-led influ...
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Detection of genetic aberrations using nucleic acids as biomarkers can be a powerful strategy for disease diagnosis and progression monitoring; however, the high heterogeneity of cells within a patien...
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UW-Madison researchers have identified and validated a set of human T cell specific biomarkers that can predicti graft-vs-host disease (GVHD) and/or relapse following allogeneic hematopoietic stem cel...
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UW-Madison researchers have developed mass spectrometry (MS) compatible nanoparticles for the selective capture and enrichment of low abundance proteins. The surface of superparamagnetic nanoparticles...
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Using two sets of comparative patient samples (hospitalized COVID-19 patients vs controls from 3 years ago, and hospitalized COVID-19 patients vs patients hospitalized for other conditions), the inven...
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UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.   
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UW – Madison researchers have determined that SARS-CoV-2 infection induces antibodies against both structural and non-structural proteins and they identified epitopes in the SARS-CoV-2 membrane ...
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The current gold standard method for COVID-19 testing is a multi-step protocol 25 involving RNA extraction using column-based or magnetic bead-based methods, followed by RT-qPCR-based detection of the...
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Prostate cancer is the most commonly diagnosed disease in men. Current clinical practice for prostate cancer screening uses the prostate specific antigen (PSA) test. However, PSA-based screening detec...
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Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet.  The sample collection system may be automated to collect sample urine from a...
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Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and p...
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The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic DNA from the human subject and (b) quantitating methylation in at l...
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A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the...
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The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine recipients, ...
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Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
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