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40 Results for 'Diagnostics & Biomarkers'
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Technology
ANTI-GATA2 MONOCLONAL ANTIBODIES
UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.
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Emery Bresnick, Daniel Matson | P220242US01
Technology
IDENTIFICATION OF SARS-COV-2 EPITOPES DISCRIMINATING COVID-19 INFECTION FROM CONTROL AND METHODS OF USE
UW – Madison researchers have determined that SARS-CoV-2 infection induces antibodies against both structural and non-structural proteins and they identified epitopes in the SARS-CoV-2 membrane ...
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Irene Ong, David O'Connor, Miriam Shelef, Anna Heffron, David Baker, Maya Amjadi, Sean McIlwain, Saniya Khullar | P210048WO01
Technology
ONE-STEP SAMPLE EXTRACTION CASSETTE AND METHOD FOR POINT-OF-CARE MOLECULAR TESTING
The current gold standard method for COVID-19 testing is a multi-step protocol
25 involving RNA extraction using column-based or magnetic bead-based methods,
followed by RT-qPCR-based detection of the...
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Duane Juang, Terry Juang, David Beebe | P210247US01
Technology
Image Analysis of Histologically Normal Prostate Biopsies Predicts Cancer Presence
Prostate cancer is the most commonly diagnosed disease in men. Current clinical practice for prostate cancer screening uses the prostate specific antigen (PSA) test. However, PSA-based screening detec...
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David Jarrard, Bing Yang, Peter LaViolette | P190032US02
Technology
Toilet, Testing and Monitoring Systems
Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet. The sample collection system may be automated to collect sample urine from a...
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Joshua Coon, Michael Westphall, Ian Miller, Lloyd Smith, Keaton Mertz | P200202WO01
Technology
Epigenetic Modification of Select Genes as Markers of Hypersomnolence
Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and p...
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David Plante, Reid Alisch | P200207WO01
Technology
Microbial Glycans As A Target Of Human Intelectin
The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont | P150027US02
Technology
Probiotic Function Of Human Intelectin
The present disclosure provides for methods providing a pre/probiotic agent to a subject. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria, thereby prom...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont, Federico Rey | P150027US04
Technology
Epithelial Quantitation Of Histologically Normal Prostate Tissue Predicts The Presence Of Cancer In Tissue Biopsies
A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the...
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David Jarrard, Bing Yang | P170023US02
Technology
Unbiased Dna Methylation Markers Define An Extensive Field Defect In Histologically Normal Prostate Tissues Associated With Prostate Cancer: New Biomarkers For Men With Prostate Cancer
A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic DNA from the human subject and (b) quantitating methylation in at l...
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David Jarrard, Bing Yang | P170024US02
Technology
Bystander Immune Suppression As A Predictor For Response To A Vaccine
The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine recipients, ...
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Douglas McNeel, William Burlingham | P100331US02
Technology
Biomarkers For Early Diagnosis And Differentiation Of Mycobacterial Infection
Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
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Adel Talaat, Chia-Wei Wu | P190048US02
Technology
Antibodies Targeting Glioblastoma Stem-Like Cells And Methods Of Use Thereof
The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Eric Shusta, Michael Zorniak, Paul Clark, Yongku Cho, Benjamin Umlauf, John Kuo | P180018US02
Technology
Methods And Systems For Isolating And Identifying Nucleic Acid From A Plurality Of Microorganisms And Viruses
The disclosure relates to laboratory and bioinformatics methods for isolating, detecting, and characterizing microbes in biological samples using metagenomic approaches.
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Tony Goldberg, Samuel Sibley | P160266US02
Technology
High Throughput Nucleic Acid Profiling Of Single Cells
Methods of profiling the nucleic acid composition of single cells and tools for same. The methods can include isolating a single cell in a liquid droplet, lysing the single cell in the liquid droplet ...
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Philip Romero, Leland Hyman | P180094US02
Technology
Method Of Determining The Efficacy Of Antimicrobials
A method of determining efficacy of an antimicrobial treatment in a subject includes calculating a breath delta value (BDV) for each of at least six breath samples acquired from the subject over a 24 ...
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Mark Cook, Daniel Butz, Ann O'Rourke | P170242US02
Technology
Nanoengineered Surfaces For Cancer Biomarker Capture
Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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Seungpyo Hong, Michael Poellmann | P180105US02
Technology
Using Liquid Crystal To Detect Endotoxin In The Presence Of One Or More Potential Masking Agents
Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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Nicholas Abbott, Abhijit Dan | P160072US02
Technology
Multicolor Reporter Cells for Detecting and Quantifying HIV-1
It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Nathan Sherer, Jordan Becker | P160337US02
Technology
Blood Protein Biomarkers for Detection of Colon Cancer
Colorectal cancer is a major cause of cancer-related morbidity and mortality in developed nations, causing more than 600,000 deaths worldwide every year. While early detection of localized colorectal ...
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Michael Sussman, William Dove, Melanie Ivancic, Jennifer Pleiman, Edward Huttlin, Perry Pickhardt, Xiaodi Chen, Amy Irving, Adrian Hegeman, Mark Reichelderfer, Gregory Kennedy | P150077US02
Technology
Biomarkers For Breast Cancer And Methods Of Use Thereof
Advances in screening and detection have led to an increase in the diagnosis of early stage breast cancer. Plotting the optimal course of treatment (i.e., more or less aggressive) remains a challenge,...
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James Shull | P160213US02
Technology
Enhanced Endotoxin Detection: New Advantages in Liquid Crystal Assays for Gram-Negative Pathogens
Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Nicholas Abbott, Abhijit Dan | P160072WO01
Technology
Field Test for Mycobacterial Infections
Mycobacterial infections cause major health problems for people and animals, including human tuberculosis, bovine tuberculosis and Johne’s disease. Johne’s disease (or paratuberculosis) afflicts 9...
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Adel Talaat | P150020US02
Technology
Biomarkers for Detecting Prostate Cancer
Prostate cancer is the second most common cancer in American men, causing more than 27,000 deaths every year. An estimated one man in seven will be diagnosed with prostate cancer during his lifetime.
...
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David Jarrard, Bing Yang | P130258US03
Technology
Assay to Determine Risk of Fungal Infection
Fungal infections such as aspergillosis and Valley Fever can be life threatening, particularly in immune-compromised patients. These patients are vulnerable to fungal strains that flourish in hospital...
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Bruce Klein, Marcel Wuethrich | P140236US02