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43 Results for 'Diagnostics & Biomarkers'
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Technology
IDENTIFYING DISEASE-CAUSING HUMAN DDX41 GENETIC VARIANTS
UW-Madison researchers have developed a genetic rescue assay that discriminates the activities of wild type DDX41 from those of human myeloid malignancy-associated germline and somatic DDX41 mutants. ...
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Emery Bresnick, Jeong-Ah Kim | P230033US02
Technology
An Optimized, More Efficient Method for Characterizing Microorganisms and Viruses Using Metagenomics
Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Tony Goldberg, Samuel Sibley | P160266US02
Technology
Fibroblast Activation ImmunoPET for Detection of Fibrosis Activity
UW-Madison researchers have developed a novel, cross-species antibody to fibroblast activation protein (FAP). The researchers identified the antibody through screening of a phage display library. That...
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Reinier Hernandez, Aaron LeBeau, Zachary Rosenkrans, Chris Massey, Joseph Gallant | P220283US02
Technology
Developing Specific Rheumatoid Factors as Diagnostic and Therapeutic Tools
Rheumatoid factors (RFs) are antibodies that commonly develop in patients with rheumatoid arthritis (RA), an incurable autoimmune disease that affects ~1% of the population. RFs bind to IgG and other ...
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Miriam Shelef | P220084US02
Technology
Detecting Circulating Tumor DNA at Very Low Levels
Minimal Residual Disease (MRD) detection assays such as those used to detect the presence of cancer at early stages have largely relied on single nucleotide variant (SNV) detection in plasma DNA. Whil...
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Muhammed Murtaza, Bradon McDonald, Kirsten Dennison | P230118US01
Technology
UNIVERSAL METHOD FOR PARASITE AND EUKARYOTIC ENDOSYMBIONT IDENTIFICATION
UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method cons...
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Tony Goldberg, Leah Owens | P220194WO01
Technology
INFLUENZA VIRUS ISOLATE A/WISCONSIN/588/2019
Staff at the Wisconsin State Laboratory of Hygiene have prepared influenza virus isolate A/Wisconsin/588/2019 (FR-1758), as part of their influenza surveillance work through the national CDC-led influ...
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Allen Bateman | P230354US01
Technology
High-Throughput Microfluidics Platform Enables Scalable Single-Cell Nucleic Acid Biomarker Detection
Detection of genetic aberrations using nucleic acids as biomarkers can be a powerful strategy for disease diagnosis and progression monitoring; however, the high heterogeneity of cells within a patien...
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Philip Romero, Leland Hyman | P180094US02
Technology
T CELL SPECIFIC BIOMARKERS FOR PREDICTING GRAFT-VS-HOST DISEASE AND HEMATOPOIETIC MALIGNANCY RELAPSE FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION AND TREATMENT THEREOF
UW-Madison researchers have identified and validated a set of human T cell specific biomarkers that can predicti graft-vs-host disease (GVHD) and/or relapse following allogeneic hematopoietic stem cel...
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Christian Capitini, Nicholas Hess, Kalyan Nadiminti, Peiman Hematti, Jenny Gumperz | P220161US02
Technology
AN ACCURATE AND COMPREHENSIVE CARDIAC TROPONIN I ASSAY ENABLED BY NANOTECHNOLOGY AND PROTEOMICS
UW-Madison researchers have developed mass spectrometry (MS) compatible nanoparticles for the selective capture and enrichment of low abundance proteins. The surface of superparamagnetic nanoparticles...
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Ying Ge, Song Jin, Timothy-Neil Tiambeng, David Roberts | P190235US02
Technology
DETECTING, PREDICTING SEVERITY OF, AND/OR PREDICTING TREATMENT RESPONSE TO RESPIRATORY VIRUS INFECTION
Using two sets of comparative patient samples (hospitalized COVID-19 patients vs controls from 3 years ago, and hospitalized COVID-19 patients vs patients hospitalized for other conditions), the inven...
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Reid Alisch, Kirk Hogan, Andy Madrid, Ariel Jaitovich | P210192US02
Technology
ANTI-GATA2 MONOCLONAL ANTIBODIES
UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.
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Emery Bresnick, Daniel Matson | P220242US01
Technology
IDENTIFICATION OF SARS-COV-2 EPITOPES DISCRIMINATING COVID-19 INFECTION FROM CONTROL AND METHODS OF USE
UW – Madison researchers have determined that SARS-CoV-2 infection induces antibodies against both structural and non-structural proteins and they identified epitopes in the SARS-CoV-2 membrane ...
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Irene Ong, David O'Connor, Miriam Shelef, Anna Heffron, David Baker, Maya Amjadi, Sean McIlwain, Saniya Khullar | P210048WO01
Technology
ONE-STEP SAMPLE EXTRACTION CASSETTE AND METHOD FOR POINT-OF-CARE MOLECULAR TESTING
The current gold standard method for COVID-19 testing is a multi-step protocol
25 involving RNA extraction using column-based or magnetic bead-based methods,
followed by RT-qPCR-based detection of the...
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Duane Juang, Terry Juang, David Beebe | P210247US01
Technology
Image Analysis of Histologically Normal Prostate Biopsies Predicts Cancer Presence
Prostate cancer is the most commonly diagnosed disease in men. Current clinical practice for prostate cancer screening uses the prostate specific antigen (PSA) test. However, PSA-based screening detec...
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David Jarrard, Bing Yang, Peter LaViolette | P190032US02
Technology
Toilet, Testing and Monitoring Systems
Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet. The sample collection system may be automated to collect sample urine from a...
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Joshua Coon, Michael Westphall, Ian Miller, Lloyd Smith, Keaton Mertz | P200202WO01
Technology
Epigenetic Modification of Select Genes as Markers of Hypersomnolence
Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and p...
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David Plante, Reid Alisch | P200207WO01
Technology
Microbial Glycans As A Target Of Human Intelectin
The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont | P150027US02
Technology
Unbiased Dna Methylation Markers Define An Extensive Field Defect In Histologically Normal Prostate Tissues Associated With Prostate Cancer: New Biomarkers For Men With Prostate Cancer
A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic DNA from the human subject and (b) quantitating methylation in at l...
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David Jarrard, Bing Yang | P170024US02
Technology
Epithelial Quantitation Of Histologically Normal Prostate Tissue Predicts The Presence Of Cancer In Tissue Biopsies
A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the...
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David Jarrard, Bing Yang | P170023US02
Technology
Bystander Immune Suppression As A Predictor For Response To A Vaccine
The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine recipients, ...
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Douglas McNeel, William Burlingham | P100331US02
Technology
Using Liquid Crystal To Detect Endotoxin In The Presence Of One Or More Potential Masking Agents
Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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Nicholas Abbott, Abhijit Dan | P160072US02
Technology
Nanoengineered Surfaces For Cancer Biomarker Capture
Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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Seungpyo Hong, Michael Poellmann | P180105US02
Technology
Antibodies Targeting Glioblastoma Stem-Like Cells And Methods Of Use Thereof
The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Eric Shusta, Michael Zorniak, Paul Clark, Yongku Cho, Benjamin Umlauf, John Kuo | P180018US02
Technology
Biomarkers For Early Diagnosis And Differentiation Of Mycobacterial Infection
Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
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Adel Talaat, Chia-Wei Wu | P190048US02