Wisconsin Alumni Research Foundation

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WARF Advances in Health Care | June 2023

Top licensing prospects from the University of Wisconsin-Madison

Gene Editing to Treat Pompe Disease and Other Autosomal Recessive Disorders
UW-Madison researchers have developed a complexed CRISPR-Cas gene editing approach for treating Pompe disease.
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Methods to Screen Antifungal Compounds and Treat Fungal Diseases by Inhibiting Spore Germination
Four FDA-approved compounds and 108 druggable compounds with germination-inhibiting properties and high potential for further development into effective antifungal therapeutics have been identified using this approach.
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Generating LPS-Specific Exosome-Educated Macrophages
This strategy can be used to produce therapeutic macrophages that offer a potential therapy for radiation damage.
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Hepatocytes and Hematopoietic Progenitors from Human Embryonic Stem Cells 
This system involves differentiating embryonic stem cells in co-culture with mouse embryonic fibroblasts under specific conditions to give rise to both hepatic and hematopoietic lineages.
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Identification of SARS-COV-2 Epitopes
These previously unknown/unidentified epitopes could be considered in the development of vaccines and improved diagnostics.
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Novel Adjuvant for Animal and Human Vaccines
Using Quil-A chitosan spherical nanostructure complexes as adjuvants induces a robust immune response.
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