Estrogen-related receptor alpha (ERRalpha) is a recently discovered biomarker and treatment target for breast cancer (See WARF reference number P03031US). However, few, if any reliable monoclonal anti...
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The transmembrane protein dystroglycan is associated with autosomal recessive muscular dystrophies. Although dystroglycan is glycosylated in a tissue-specific manner, no commercial monoclonal antibodi...
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RNA polymerase, the enzyme responsible for making RNA from a DNA or RNA template, is one of the most important proteins in all life forms.
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Mass spectroscopy is a widely used technique for detecting and analyzing molecules, including biochemical entities such as amino acids, proteins, short nucleic acids, metabolites and other small molec...
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Sulfonylurea receptors (SURs) regulate the opening and closing of ATP-sensitive potassium channels (KATP).  They play important roles in insulin secretion in the pancreas and myocardial protection in...
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The Epstein-Barr virus (EBV) is a member of the Herpes family of viruses.  The genome of this virus usually is maintained as a nuclear plasmid in the cells it infects.  A replication origin (oriP) i...
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Human embryonic stem (ES) cells are potentially capable of supplying cells and tissues for replacement of defective human tissue. However, procedures currently used to culture human ES cells involve t...
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The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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Membrane proteins perform many crucial functions in vivo.  Physical characterization of these proteins, including the determination of three-dimensional crystal structures, could improve fundamental ...
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The green fluorescent protein (GFP) from the jellyfish Aequorea victoria is an extremely useful tool in biochemistry, molecular biology and diagnostics. This protein has been used to study gene expres...
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Effective and non-destructive treatments are needed for diabetic retinopathy, a major cause of blindness in the United States. Thrombospondin1 (TSP1), a matricellular protein that inhibits angiogenesi...
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Most schemes for detecting toxins or other chemicals are based on complex electronic, photonic and/or electrochemical methods, or on more elegant biomolecular methods, such as ELISA (Enzyme-Linked Imm...
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Sensors currently used for detecting the presence of a given analyte, such as a toxin, in solution or in air require direct contact with a power supply. Distributed sensing systems or “sensor networ...
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Liquid crystals have been widely explored for applications such as display and sensing technologies. Lyotropic liquid crystals, which become more ordered as they become more concentrated within a solv...
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Biomedical imaging allows physicians to detect the onset of disease, injury and other disorders at an early stage, and to monitor their progression.
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Molecules that contain two functional groups of distinct reactivity can be used to link two biomolecules or to immobilize a biomolecule on a surface, such as a protein microarray. These bifunctional m...
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Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Inhibitors of SCD may be useful therapeutics for diseases such as obesity and diabetes.
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Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be cultured using standard techniques represent only a small f...
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Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be cultured using standard techniques represent only a small f...
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When using live vertebrate animals, principal investigators for any activity supported by a Public Health Service (PHS) agency, such as the FDA, NIH or CDC, must comply with the PHS policy on Humane C...
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Although the yeast Saccharomyces cerevisiae is often used to express foreign proteins for industrial or therapeutic uses, production of these heterologous proteins is far from optimal. Current methods...
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Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules into the environment. When a certain nu...
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Dioxin is a highly toxic environmental pollutant that acts primarily through the aryl hydrocarbon receptor. Exposure to dioxin has adverse effects on the immune, nervous, endocrine and reproductive sy...
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Glaucoma is a group of diseases that can result in vision loss and blindness. According to the World Health Organization, glaucoma is the second leading cause of blindness worldwide. Glaucoma causes a...
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Sulfonylurea receptors (SURs) regulate the opening and closing of ATP-sensitive potassium channels (KATP). They play important roles in insulin secretion in the pancreas and myocardial protection in t...
Learn More