UW-Madison researchers have developed a mouse model (PPCD1) for Posterior Polymorphous Corneal Dystrophy (PPCD). They have also developed second mouse model (see P250382US02 below).
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A UW-Madison researcher has engineered Lactobacillus reuteri (L. Reuteri VPL1014) to encode a native antirepressor protein whose expression is placed under the control of an inducible promoter along w...
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UW-Madison researchers have developed an AI-based method for designing humanized CAR sequences. Using this method, they developed two novel humanized CD19 sequences that can be used for production of ...
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UW-Madison researchers have developed a method for stopping seizures in patients suffering from acquired epilepsy. The treatment strategy utilizes Tofacitinib, a JAK/STAT inhibitor currently prescribe...
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A UW-Madison researcher has developed an oral combination therapy for treating fibrolamellar carcinoma (FLC) that utilizes a CDK7 inhibitor and a CDK9 inhibitor. The researcher created a cancer cell l...
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UW-Madison researchers in collaboration with researchers at the Oak Ridge National Laboratory have developed chelated antimony (Sb) that can be used for targeted Auger radiotherapy. While 119Sb has be...
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UW-Madison researchers have developed improved methods for optimizing the characteristics of salivary gland-derived mesenchymal stromal cells (MSCs) for therapeutic administration.The inventors have d...
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UW-Madison researchers and collaborators have developed a suite of four camelid antibodies that specifically bind to fentanyl and carfentanil, a major metabolite of fentanyl. One binds specifically to...
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UW-Madison researchers have developed a non-viral method of developing CAR NK cells. The inventors tested many parameters along established processes for genetically modifying immune cells without vir...
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Schistosomiasis is an often-neglected tropical disease caused by blood flukes (helminths). The World Health Organization estimates that over 250 million people require preventive treatment for schisto...
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UW-Madison researchers have developed a workflow for identifying microbial strains that are effective in treating CDI. Using this workflow, they found that the ability for a microbiome (existing or tr...
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UW-Madison researchers have developed a focused library of CARM1 protein degraders. These degraders used a known binding molecule of CARM1 with an optimized linker attached to a Von Hippel–Lindau (V...
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UW-Madsion researchers have developed a method for reducing adiposity and promoting glucose homeostasis through consumption of tripropionin, a triglyceride containing three propionate fatty acids tail...
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UW-Madison researchers have developed a new CAR T cell technology to be used in combination with targeted radionuclide treatment for treating sold tumors. The patient is dosed with low dose targeted r...
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UW-Madison researchers in collaboration with a researcher at Clemson University have developed a chemical scaffold that potently inhibits whole Naegleria fowleri parasites in culture. They have prepar...
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UW-Madison researchers have developed a multi-functional antibiotic nanoparticle that incorporates hemoglobin and the clinically approved antifungal agent naftifine in the core which is coated with re...
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UW-Madison researchers have developed a novel camelid antibody against the cancer target cMET. As cMET is overexpressed on many tumors, this antibody may be useful for imaging tumors and/or delivering...
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UW-Madison researchers have developed a novel protocol for generating nearly pure retinal progenitors (PAX6/VSX2 positive cells) without contamination by forebrain cells. Retinas develops from precurs...
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UW-Madison and UC-San Francisco researchers have developed a treatment for macular degeneration that uses low doses of the clinically approved molecule, zoledronic acid, which is used to treat bone di...
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UW-Madison researchers have developed a method for increasing butyrate production in the gut. The method includes delivering a microbial community that include certain bacteria, yeasts, and other micr...
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UW-Madison inventors have developed a new PACE-based platform for rapid discovery of bioactive cyclic peptide protein aggregation inhibitors. By linking cyclic peptide activity to phage reproduction, ...
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UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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UW-Madison researchers have developed methods for using mesenchymal stromal cell (MSC)-derived exosomes to promote ligament and tendon healing, including improvements to the mechanical properties of t...
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UW Madison researchers and collaborators present a method of treating COVID-19 with lipid- peptide fusion antiviral therapy. Also described is a composition and method of treating Ebola with lipid-pep...
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The present invention from UW Madison researchers is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are part...
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