Therapeutics & Vaccines
L. Reuteri Engineered to Release Recombinant Products Following Antirepressor Induction Leading to Prophage Activation and Subsequent Phage-Mediated Lysis
WARF: P250219US01
Inventors: Jan Peter Van Pijkeren
The Invention
A UW-Madison researcher has engineered Lactobacillus reuteri (L. Reuteri VPL1014) to encode a native antirepressor protein whose expression is placed under the control of an inducible promoter along with the expression of a recombinant gene from the chromosome or plasmid. The gene product can be rodent-, monkey-, or human-derived, that is accumulated inside the cytoplasm. Following the induced expression of the antirepressor gene, prophage are activated after which cells are lysed. This induced lysis leads to the release of the recombinant therapeutic.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847