The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
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No well-characterized prostate stromal cell lines currently exist.
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The human either-a-go-go related gene (HERG1 or KCNH2) potassium channel is critical to maintaining normal cardiac rhythm. Because unintended block of HERG channel activity by drugs can cause long QT ...
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Re-polarization of the cardiac action potential, which plays a critical role in maintaining normal cardiac rhythm, occurs mainly due to the action of potassium ion (K+) currents in the heart. The most...
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One of the key potassium channels in the heart is formed by the co-assembly of protein products from the KvLQT1 (KCNQ1) and minK (KCNE1) genes, which produce the slowly activating delayed rectifier po...
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Human embryonic stem (hES) cells have the potential to provide a source of specific cell types for research and ultimately, for therapeutic transplantation into humans.
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The extensive use of neuraminidase (NA) inhibitors to treat influenza virus infections by reducing viral sialidase activity requires close monitoring for resistant variants. However, cultured cells do...
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Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and about 20 percent of head and neck cancers.
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Sulfonylurea receptors (SURs) regulate the opening and closing of ATP-sensitive potassium channels (KATP).  They play important roles in insulin secretion in the pancreas and myocardial protection in...
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Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Inhibitors of SCD may be useful therapeutics for diseases such as obesity and diabetes.
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