UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta” is a...
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Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
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HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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GATA-binding-factor 2 (GATA2) is a transcription factor involved in stem cell maintenance and hematopoietic development. The gene encoding GATA2 often suffers germline and somatic mutations, which res...
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Fragile X syndrome (FXS) is a genetic disorder characterized by mild to moderate intellectual disability and a characteristic phenotype. It is the most common form of inherited intellectual disability...
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Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
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Mitochondrial function plays a central role in longevity and healthy aging, and delayed aging by calorie restriction activates PGC-1a (peroxisome proliferator-activated receptor gamma coactivator-1 al...
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Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untransla...
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The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
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The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs ...
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Systems and methods for determining genetic variations of an organism for performing a physiological function. The systems include a number of modules that can be integrated into existing metabolic en...
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Differentiated cholinergic cells having motor neuron-like morphology and increased sensitivity to botulinum neurotoxin are provided herein. Methods of using such differentiated cells for detecting neu...
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FDA-qualified cell lines must be used for virus production for human vaccines. There are relatively few of these lines available and several (WI-38, MRC-5) used for virus production are becoming senes...
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It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Two estrogen receptor isoforms regulate normal mammary cells in response to estrogen: ERα and ERβ. ERα is currently a therapeutic target in breast cancer, and breast cancers expressing ERα are com...
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Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
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In addition to the common cold, human rhinoviruses (RV) trigger nearly half of all cases of asthma exacerbation. Wheezing illnesses in infancy caused by RV are associated with a high risk of developin...
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Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying hematopoietic development in vitro.
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Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying blood development in vitro.
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Tumor xenograft mouse models have been created by injecting human cancer cell lines into immune deficient mice. However, when the effects of various interventions on these models are assessed, the res...
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Bone morphogenetic proteins (BMPs) are critical for the formation of cartilage and its conversion into bone.
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Calcium-activated potassium channels are a type of ion channel that is important in many physiological processes.
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Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. SCDs may influence the development of diseases such as obesity, atherosclerosis and diabet...
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The human heart sodium channel beta1 subunit is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel.
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The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
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