Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
Learn More

Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
Learn More

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
Learn More

The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
Learn More

The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
Learn More

A population of brain pericyte-like cells, wherein the cells express pericyte markers but do not express ACTA2 and wherein the cells are generated from hPSCs, is disclosed herein.
Learn More

Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, ...
Learn More

Methods for derivation, culture, and maturation of small hepatic progenitor cells are described.
Learn More

The present invention relates to substantially planar vascularized brain cancer organoid and methods of using such vascularized brain cancer organoids in anti-cancer drug discovery screen. In particul...
Learn More

A method of creating an isogenic multicellular blood-brain barrier model from iPSCs is disclosed.
Learn More

Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues com...
Learn More

Alexander disease (AxD) is a rare disease of the central nervous system characterized by formation of protein aggregates within astrocytes and disruption of growth or maintenance of the myelin sheath....
Learn More

Accurately reproducing the blood-brain barrier in an in vitro setting has been a longstanding challenge. Current methods require the independent isolation of multiple cell types, and the quality of th...
Learn More

Peripheral neuropathies are a diverse group of diseases marked by degeneration of the peripheral nervous system. These diseases affect both humans and animals. In humans, the most common form is Charc...
Learn More

Human inoculum strains of rhinoviruses have been used for more than 50 years to induce experimental colds to study disease mechanisms and to test the efficacy of antiviral drugs. Traditional inocula a...
Learn More

Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
Learn More

Photoreceptors are specialized cells that capture and convert light into signals that can be processed by the retina and visual centers of the brain. Supportive cells called the retinal pigment epithe...
Learn More

Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
Learn More

In addition to the common cold, human rhinoviruses (RV) trigger nearly half of all cases of asthma exacerbation. Wheezing illnesses in infancy caused by RV are associated with a high risk of developin...
Learn More

Microsporum canis is a skin fungal pathogen that causes dermatophytosis (ringworm) most commonly in cats and dogs. Dermatophytosis clinical trials are lengthy and complicated because the nature of the...
Learn More

Neurological disorders—ranging from spinal cord injuries to Alzheimer’s disease—are among the most challenging health issues. There is an ongoing need for disease models and screening sy...
Learn More

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
Learn More

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
Learn More

Presently, there are no good rodent models for mania, which is a critical component of bipolar disorder. The most commonly used approach is to inject normal mice with amphetamines to produce hyperacti...
Learn More

The blood-brain barrier (BBB) is made up of brain microvascular endothelial cells (BMECs), which line brain capillaries and control trafficking between the bloodstream and neural tissue. Although esse...
Learn More