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29 Results for 'Disease models'
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Technology
Method Of Creating Human Pluripotent Stem Cell Derived Brain Pericyte-Like Cells
Eric Shusta, Sean Palecek, Matthew Stebbins | P170340US02
Technology
Scaffold For In Vitro Modeling And Transplantation Therapy Of Photoreceptors
Zhenqiang Ma, Juhwan Lee, Yei Hwan Jung, Michael Phillips, David Gamm, Shaoqin Gong, Inkyu Lee | P180243US02
Technology
Expansion And Maintenance Of Adult Primary Human Hepatocytes In Culture
James Thomson, Srikumar Sengupta | P180325US03
Technology
Human Pluripotent Stem Cell-Derived Brain Organoids For Cancer Modeling And Drug Screening
William Murphy, Elizabeth Aisenbrey, Elizabeth Torr, Victoria Harms, Gaurav Kaushik | P190185US02
Technology
Isogenic Blood-Brain Barrier Model
Eric Shusta, Scott Canfield, Clive Svendsen, Gad Vatine, Sean Palecek | P160286US02
Technology
Methods And Culture Substrates For Controlled Induction Of Biomimetic Neural Tissues Comprising Singular Rosette Structures
Randolph Ashton, Gavin Knight | P170180US02
Technology
Rat Model of Alexander Disease
Alexander disease (AxD) is a rare disease of the central nervous system characterized by formation of protein aggregates within astrocytes and disruption of growth or maintenance of the myelin sheath....
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Albee Messing, Tracy Hagemann | P170228US01
Technology
Blood-Brain Barrier Model
Accurately reproducing the blood-brain barrier in an in vitro setting has been a longstanding challenge. Current methods require the independent isolation of multiple cell types, and the quality of th...
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Eric Shusta, Clive Svendsen, Christian Weidenfeller | P06318US02
Technology
Genetic Testing for Acquired Peripheral Neuropathy in Dogs
Peripheral neuropathies are a diverse group of diseases marked by degeneration of the peripheral nervous system. These diseases affect both humans and animals. In humans, the most common form is Charc...
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Peter Muir, Susannah Sample, John Svaren | P160048US02
Technology
Recombinant Rhinovirus A16 for Human Inoculation Studies
Human inoculum strains of rhinoviruses have been used for more than 50 years to induce experimental colds to study disease mechanisms and to test the efficacy of antiviral drugs. Traditional inocula a...
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James Gern, Wai-Ming Lee | P170018US01
Technology
Animal Model of Brittle Bone Disease
Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
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Daniel Greenspan, Se-Jin Lee | P160036US01
Technology
Photoreceptor Scaffold for In Vitro Modeling and Transplantation Therapy
Photoreceptors are specialized cells that capture and convert light into signals that can be processed by the retina and visual centers of the brain. Supportive cells called the retinal pigment epithe...
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Zhenqiang Ma, Yei Hwan Jung, Michael Phillips, David Gamm, Shaoqin Gong | P160094US01
Technology
Adapted Rhinovirus C for Maximum Virus Yield
Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02
Technology
New Viral Propagation Method Yields Insight Into Childhood Asthma
In addition to the common cold, human rhinoviruses (RV) trigger nearly half of all cases of asthma exacerbation. Wheezing illnesses in infancy caused by RV are associated with a high risk of developin...
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James Gern, Yury Bochkov, Ann Palmenberg | P140382US02
Technology
Ringworm Fungal Strain for Infection Studies
Microsporum canis is a skin fungal pathogen that causes dermatophytosis (ringworm) most commonly in cats and dogs. Dermatophytosis clinical trials are lengthy and complicated because the nature of the...
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Douglas DeBoer, Karen Moriello | P140194US01
Technology
Understanding and Treating Nervous System Dysfunction Using Modified Fly Models
Neurological disorders—ranging from spinal cord injuries to Alzheimer’s disease—are among the most challenging health issues. There is an ongoing need for disease models and screening sy...
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Barry Ganetzky, Daniel Miller, Shannon Ballard | P120334US02
Technology
Wisconsin Miniature SwineTM for Biomedical Research
Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P130271US01
Technology
Wisconsin Miniature SwineTM for Cardiovascular Research
Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P140228US01
Technology
Mouse Model for Mania
Presently, there are no good rodent models for mania, which is a critical component of bipolar disorder. The most commonly used approach is to inject normal mice with amphetamines to produce hyperacti...
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Stephen Gammie | P100188US01
Technology
Enhanced Blood-Brain Barrier Model Outperforms All Others
The blood-brain barrier (BBB) is made up of brain microvascular endothelial cells (BMECs), which line brain capillaries and control trafficking between the bloodstream and neural tissue. Although esse...
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Eric Shusta, Samira Azarin, Sean Palecek, Ethan Lippmann | P130017US02
Technology
Improved Method to Produce Brain Microvascular Endothelial Cells for a Robust Human Blood-Brain Barrier Model
Although it is essential to healthy brain function, the blood-brain barrier (BBB) interferes with drug delivery, preventing more than 98 percent of small molecule pharmaceuticals and nearly 100 percen...
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Eric Shusta, Samira Azarin, Sean Palecek, Ethan Lippmann | P100219US02
Technology
A Model for Familial Combined Hyperlipidemia and Type II Diabetes Mellitus
People with familial combined hyperlipidemia (FCH) are hypertriglyceridemic and hypercholesterolemic, and often go on to develop type II diabetes mellitus in middle age. Current FCH mouse models resul...
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Lisa Krugner-Higby, Janice Wagner | P01090US
Technology
Collection of Temperature-Sensitive Paralytic Mutants of Drosophila
Drosophila commonly are used as model organisms. As many as 70 percent of human disease genes have homologues in Drosophila, making these organisms useful for identifying particular disease gene...
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Barry Ganetzky, Robert Kreber | P99190US
Technology
Genetically Modified Mouse Model Displaying Abnormalities in Circadian Rhythms
Behavioral and physiological processes in nearly all organisms display 24-hour rhythms that are controlled by a circadian pacemaker, or clock. Over the past several years, many proteins and transcript...
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Christopher Bradfield, Maureen Bunger, Susan Mary Moran | P01135US
Technology
Immortalized Cells from the Mouse Urogenital Sinus and Adult Mouse Prostate
No well-characterized prostate stromal cell lines currently exist.
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Wade Bushman | P03405US