UW-Madison and Morgridge Institute researchers have identified developed an improved method for depositing samples on electron microscopy (EM) grids. The technology leverages a modified mass spectrome...
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UW-Madison researchers have developed an improved sample handling system for the preparation of samples to be analyzed using cryo-electron microscopy (cryo-EM). The system includes a retractable grid ...
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UW-Madison researchers have developed an improved technique for cryogenically fixing biological samples in amorphous ice for analysis by cryo-electron microscopy (cryo-EM).  Analyte particles are...
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UW Madison Researchers have improved upon conventional expanded microscopy. They have developed novel 4-fold and a 12-fold mExM (modified expansion microscopy) methodologies, which stably and reproduc...
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A lithium ion indicator material for a lithium ion battery is provided, the material comprising a lithium ion battery material and Li+ profluorophore dispersed within or on the lithium ion battery mat...
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A method (100) can be provided to determine the throughput speed v of at least one pore (1), comprising: • feeding (110), using a driving force F, a filiform calibration element (2) through the pore...
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The present invention provides methods for controllably forming a layer of amorphous ice and other amorphous solids on a substrate, and also provides cryoelectron microscopy (cryo-EM) sample preparati...
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A new cancer treatment being studied at a few major centers including UW Health is CAR T (Chimeric Antigen Receptor T cell) therapy. CAR T therapy uses a patient's own cells and 'reengineers' them to ...
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The importance of T cells in immunotherapy is driving the development of technologies to better characterize T cells and improve therapeutic efficacy. One specific objective is assessing antigen-induc...
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Regenerative medicine requires a practical, high throughput method of assessing the cellular components of multicellular entities before transplantation. Such a method would have many clinical and res...
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Label-free sensing methods could enable detection and characterization of chemical species at the single molecule level without the aid of probes or modifications to the target of interest. Such capab...
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Single molecule spectroscopy and microscopy – a popular tool for biological, biophysical and chemical characterization – generally requires the use of fluorescent molecules. Researchers at UW–M...
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Studying molecular properties in complex chemical and biological samples, including live cells, requires sufficient spatial resolution and contrast between different substructures. To achieve enhanced...
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Atomically sharp micro-fabricated tips are used in atomic force microscopy (AFM) for scanning near-field microwave microscopy (SNMM) to create an image of the tiny topography on or under a surface. Th...
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A whispering gallery mode (WGM) is a type of electromagnetic wave that travels around a concave surface. Such waves can propagate at the edge of a very small structure called an optical microcavity. W...
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Intrinsic and extrinsic fluorescent markers can help surgeons target and rapidly identify tumorous tissue. The signals given off by these markers are relatively faint and normally viewed with a fluore...
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Confocal microscopy is used to view biological tissue through intervening tissues or structures. Multiphoton confocal microscopy uses a focused beam of photons to provide high-resolution images of tis...
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The atomic force microscope (AFM), one of many types of scanned-proximity probe microscopes, images a sample by lightly touching it with a probe tip attached to the end of an extremely flexible leaf s...
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Although detecting high-frequency magnetic fields is important in MRI, NMR and magnetic resonance force microscopes, it is more difficult to design magnetic field sensors at high frequencies (greater ...
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The atomic force microscope (AFM), one of many types of scanned-proximity probe microscopes, images a sample by lightly touching it with a probe tip attached to the end of an extremely flexible leaf s...
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Atomic force microscopes (AFM), scanning tunneling microscopes (STM) and scanning microwave microscopes are three different instruments used to create images of nano-structures. Currently, the three i...
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Quantum-entanglement is a phenomenon in which the quantum states of two objects become correlated and remain correlated, even when the objects are physically separated from each other. Quantum-entangl...
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