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23 Results for 'Microscopy'
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Technology
Fluorescent Indicator of Lithium Ions
UW-Madison researchers have developed a novel profluorophore that binds to lithium ions with high specificity, inducing a fluorescent signal. The fluorescent indicator can be seamlessly integrated int...
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Randall Goldsmith | P150162US02
Technology
Microtubule Labeled Slides Used for Calibration of Various Fluorescence Microscopes
Fluorescent microscopes, including wide-field, confocal and super-resolution, are widely used instruments in a variety of research fields but require routine calibration and maintenance. Calibration r...
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Aussie Suzuki | P200284US01
Technology
Gas Phase Sample Preparation For Cryo-Electron Microscopy
Single particle cryo-electron microscopy (cryo-EM) is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many n...
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Joshua Coon, Michael Westphall | P170235US02
Technology
Biomolecular Vapor Deposition (BVD) and Grid Holder/Mounting System for In Vacuo Preparation of Cryo-Electron Microscopy Samples
Single particle cryo-electron microscopy is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many new biologi...
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Joshua Coon, Michael Westphall | P200355US02
Technology
Freezing and Jacketing Gas-Phase Biomolecules with Amorphous Ice for Electron Microscopy
Single particle cryo-electron microscopy (cryo-EM) is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many n...
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Joshua Coon, Michael Westphall | P200354WO01
Technology
Optimized Economical and Modulatable Isotropic Expansion Microscopy
Light microscopy is a well-established tool to study protein dynamics and protein functions in fixed and living cells. One limitation of light microscopy is that its diffraction limit (optical resolut...
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Aussie Suzuki, Mark Burkard, Roshan Norman, Emma Recchia | P200189US02
Technology
Matrices and systems for preservation of biomolecules in vacuum
UW-Madison and Morgridge Institute researchers have identified developed an improved method for depositing samples on electron microscopy (EM) grids. The technology leverages a modified mass spectrome...
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Joshua Coon, Michael Westphall, Kenneth Lee, Austin Salome, Timothy Grant, Jean Lodge | P220041WO01
Technology
A Method To Determine The Throughput Speed Of A Pore
A method (100) can be provided to determine the throughput speed v of at least one pore (1), comprising: • feeding (110), using a driving force F, a filiform calibration element (2) through the pore...
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Robert Blick, Paul Gwozdz, Abhishek Bhat | P160202US02
Technology
Method and Device to Screen and Sort Cancer Immunotherapy Cells
A new cancer treatment being studied at a few major centers including UW Health is CAR T (Chimeric Antigen Receptor T cell) therapy. CAR T therapy uses a patient's own cells and 'reengineers' them to ...
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Melissa Skala, Alexandra Walsh | P180292US02
Technology
Algorithms to Classify T Cell Activation by Autofluorescence Imaging
The importance of T cells in immunotherapy is driving the development of technologies to better characterize T cells and improve therapeutic efficacy. One specific objective is assessing antigen-induc...
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Melissa Skala, Anthony Gitter, Zijie Wang, Alexandra Walsh | P190306US02
Technology
Multiphoton Flow Cytometer for High Throughput Analysis of Multicellular Aggregates Like Pancreatic Islets
Regenerative medicine requires a practical, high throughput method of assessing the cellular components of multicellular entities before transplantation. Such a method would have many clinical and res...
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Brenda Ogle, Luis Fernandez, Kevin Eliceiri, Matthew Hanson | P07386US
Technology
All-Glass Optical Microresonator for Single Molecule Spectroscopy and More
Label-free sensing methods could enable detection and characterization of chemical species at the single molecule level without the aid of probes or modifications to the target of interest. Such capab...
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Randall Goldsmith, Kassandra Knapper, Kevin Heylman | P150382US01
Technology
Microcavity Method for Single Molecule Spectroscopy
Single molecule spectroscopy and microscopy – a popular tool for biological, biophysical and chemical characterization – generally requires the use of fluorescent molecules. Researchers at UW–M...
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Randall Goldsmith, Kevin Heylman | P140153US03
Technology
Multidimensional Imaging with Improved Contrast
Studying molecular properties in complex chemical and biological samples, including live cells, requires sufficient spatial resolution and contrast between different substructures. To achieve enhanced...
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John Wright, Erin Boyle | P140021US02
Technology
Microscope Probe Having an Ultra-Tall Tip
Atomically sharp micro-fabricated tips are used in atomic force microscopy (AFM) for scanning near-field microwave microscopy (SNMM) to create an image of the tiny topography on or under a surface. Th...
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Daniel van der Weide, Yaqiang Wang | P06244US
Technology
Tuning Optical Microcavities
A whispering gallery mode (WGM) is a type of electromagnetic wave that travels around a concave surface. Such waves can propagate at the edge of a very small structure called an optical microcavity. W...
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Randall Goldsmith, Kevin Heylman | P140153US01
Technology
Monitoring Tissue Fluorescence in Bright Light
Intrinsic and extrinsic fluorescent markers can help surgeons target and rapidly identify tumorous tissue. The signals given off by these markers are relatively faint and normally viewed with a fluore...
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Thomas (Rock) Mackie, Adam Uselmann, Andreas Velten, Surendra Prajapati, Kevin Eliceiri | P130298US01
Technology
Optical System for Correction of Tissue-Induced Aberration
Confocal microscopy is used to view biological tissue through intervening tissues or structures. Multiphoton confocal microscopy uses a focused beam of photons to provide high-resolution images of tis...
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Andrew Sheinis | P07259US
Technology
Batch Fabrication of High Aspect Ratio Micromechanical Probe Tips
The atomic force microscope (AFM), one of many types of scanned-proximity probe microscopes, images a sample by lightly touching it with a probe tip attached to the end of an extremely flexible leaf s...
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Daniel van der Weide, Yaqiang Wang | P05350US
Technology
Mechanical Force Detection of Magnetic Fields Using Heterodyne Demodulation
Although detecting high-frequency magnetic fields is important in MRI, NMR and magnetic resonance force microscopes, it is more difficult to design magnetic field sensors at high frequencies (greater ...
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Daniel van der Weide, Charles Paulson, Thomas Grist, Modhurin Banerjee | P04127US
Technology
Plastic Cantilevers for Atomic Force Microscopy
The atomic force microscope (AFM), one of many types of scanned-proximity probe microscopes, images a sample by lightly touching it with a probe tip attached to the end of an extremely flexible leaf s...
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Daniel van der Weide, Andrew Stevens, Charles Paulson | P04378US
Technology
Microcoaxial Probes Made from Strained Semiconductor Bilayers
Atomic force microscopes (AFM), scanning tunneling microscopes (STM) and scanning microwave microscopes are three different instruments used to create images of nano-structures. Currently, the three i...
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Robert Blick | P04007US
Technology
Method of Producing Short-Wavelength Quantum-Entangled Light Beams
Quantum-entanglement is a phenomenon in which the quantum states of two objects become correlated and remain correlated, even when the objects are physically separated from each other. Quantum-entangl...
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Mark Saffman, Oo-Kaw Lim | P07323US