UW-Madison researchers have created a “cellular hive” that addresses the shortcomings of existing immune checkpoint blockade (ICB)-based immunotherapy. In short, the inventors leverage a two-part ...
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A UW-Madison researcher and colleagues have developed methods of using probiotic bacteria engineered to express IL-22 or IFN-β, alone or in combination with an immune checkpoint therapy and/or an irr...
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Building off earlier work relating to mineral coatings, UW-Madison researchers have extended this work to FeOs to generate mineral-coated FeO microparticles (FeO MCMs). The FeO MCMs are created using ...
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UW-Madison researchers have developed a biocompatible alginate-based hydrogel containing Pexidartinib (PLX) loaded nanoparticles (PLX-NPs) alone or in combination with platelet conjugated aPD-1 (P-aPD...
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UW-Madison researchers have developed a combination of low dose radiation with a CAR T cell to treat solid tumors. They provided a low dose of targeted radionuclide therapy given prior to CAR T cell i...
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A UW-Madison researcher has developed a web-based atlas of cell surface target (CST) protein expression across various cancer types. This system can be used to identify understudied drug targets for t...
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UW-Madison researchers have developed a glioblastoma cancer vaccine using primary tumor cells transfected with a genetic construct expressing a fusion of IL-7 and GM-CSF. The transfected cells are tre...
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UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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UW-Madison researchers have developed an AI-based method for designing humanized CAR sequences. Using this method, they developed two novel humanized CD19 sequences that can be used for production of ...
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A UW-Madison researcher has developed an oral combination therapy for treating fibrolamellar carcinoma (FLC) that utilizes a CDK7 inhibitor and a CDK9 inhibitor. The researcher created a cancer cell l...
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UW-Madison researchers in collaboration with researchers at the Oak Ridge National Laboratory have developed chelated antimony (Sb) that can be used for targeted Auger radiotherapy. While 119Sb has be...
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UW-Madison researchers have developed a non-viral method of developing CAR NK cells. The inventors tested many parameters along established processes for genetically modifying immune cells without vir...
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UW-Madison researchers have developed a focused library of CARM1 protein degraders. These degraders used a known binding molecule of CARM1 with an optimized linker attached to a Von Hippel–Lindau (V...
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UW-Madison researchers have developed a new CAR T cell technology to be used in combination with targeted radionuclide treatment for treating sold tumors. The patient is dosed with low dose targeted r...
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UW-Madison researchers have developed a novel camelid antibody against the cancer target cMET. As cMET is overexpressed on many tumors, this antibody may be useful for imaging tumors and/or delivering...
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UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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UW-Madison researchers have developed an improved delivery system that is able to penetrate the extracellular matrix (ECM) and shuttle surface-conjugated protein cages, composed of collagenases and an...
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UW-Madison researchers have developed ferritin-targeting proteolysis targeting chimeras (PROTACs) to establish an iron excess stress inside cancer cells. The PROTAC structure contains oleic acid for b...
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UW researchers have created a biological therapeutic that stimulates the immune system to fight solid tumors. The researchers fused the cytokines IL-6 and IL- together to form a bifunctional biomol...
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UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small...
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Theranostics, a term derived from a combination of therapeutics and diagnostics, is an emerging field of medicine where specific radionuclide disease-targeting agents are used to diagnose and treat me...
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The present technology from UW Madison inventors provides nanoparticles comprising a positively charged polymer (e.g., polylysine) electrostatically bound to iron oxide nanoparticles and CpG oligodeox...
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Ex vivo expansion and activation of T cells are prerequisites for any form of genetically engineered T cell immunotherapy. Several expansion and activation methodologies have been developed. However, ...
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