Wisconsin Alumni Research Foundation

Technology

Dramatically More Sensitive Ion Channel Antenna

Nearly half of all diseases involve ion channels – channels in cell membranes that control the flow of ions into and out of cells. Certain channels open in response to natural signal molecules a...
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Robert Blick, Abhishek Bhat | P130074US01

Technology

Patch Clamp Providing On-Chip Thermal Control

Approximately half of all diseases affect the function of ion channels in cell membranes. Testing the flow of ions and molecules through these membranes clearly is vital to drug discovery and research...
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Robert Blick | P110325US01

Technology

Controllable Murine Models of First Pass Metabolism

The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
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Christopher Bradfield, Jacqueline Walisser, Tami Thomae | P04330US

Technology

HERG CDNA with Native PolyA Tail

The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
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Gail Robertson, Eugenia Jones, Blake Anson | P05401US

Technology

Human Heart Sodium Channel Beta1 Subunit (SCNB1)

The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
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Jonathan Makielski, Bin Ye | P03207US

Technology

HERG-1 Transfected HEK 293 Cell Line B

Re-polarization of the cardiac action potential, which plays a critical role in maintaining normal cardiac rhythm, occurs mainly due to the action of potassium ion (K+) currents in the heart. The most...
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Craig January, Zhengfeng Zhou, Qiuming Gong, Gail Robertson, Blake Anson, Matthew Trudeau, Corey Anderson | P04289US

Technology

Cell Line Stably Expressing KvLQT1 and minK

One of the key potassium channels in the heart is formed by the co-assembly of protein products from the KvLQT1 (KCNQ1) and minK (KCNE1) genes, which produce the slowly activating delayed rectifier po...
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Craig January, Sridharan Rajamani, Corey Anderson | P03073US

Technology

Method to Screen for Novel Antibiotics

The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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Bernard Weisblum, Robert Giannattasio, Arcady Grenader, Andrew Ulijasz, David Kovalic | P96061US

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