Wisconsin Alumni Research Foundation

Technology

Mouse Models for Protein Granule Diseases

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
Learn More
Wei Guo | P210193US01

Technology

Immortalized Vocal Fold Fibroblasts

Normal vibration of vocal folds (aka vocal cords) depends on the tissue's composition and viscoelasticity. When that composition is altered by scarring or damage, the vibratory functionality of the vo...
Learn More
Susan Thibeault, Xia Chen | P190232US01

Technology

Methods Of Making Unbiased Phage Libraries

Described herein is a method of preparing an unbiased library of phage variants,comprising (a) preparing a population of “acceptor phage”; (b) removing an endogenoustarget gene and inserting gene ...
Learn More
Srivatsan Raman, Phil Huss | P200126US02

Technology

SufFeSient Cells

The commercially available E. coli strain BL21 λDE3 is commonly used for inducibly overexpressing recombinant proteins. Many derivatives of BL21 cells have been developed and commercialized, wi...
Learn More
Patricia Kiley, Erin Mettert | P190138US01

Technology

Vq Myeloma Cell Lines

UW Madison researchers' present invention is a set of two, new transgenic mouse multiple myeloma (MM) cell lines. Transgenic mice were developed expressing mutations in RAS pathway genes found in ...
Learn More
Jing Zhang | P210035US01

Technology

Human Basal Cell Carcinoma Cell Line UW-BCC1

Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
Learn More
Vladimir Spiegelman, Felicite Noubissi Kamdem | P140339US01

Technology

Kras Conditional Knockout Allele

Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellu...
Learn More
Jing Zhang | P210181US01

Technology

CHO Cell Line Expressing HERG-1 Potassium Channels

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
Learn More
Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US

Technology

SARS-CoV-2 Polymerase Production

Coronaviruses are a group of RNA viruses that can cause disease. Some, such as the common cold, can cause mild disease, while others, such as COVID-19, can be lethal. An unusual characteristic of coro...
Learn More
Robert Kirchdoerfer | P210033US01

Technology

Model System for Identifying Anti-Cancer Agents

The Hedgehog (Hh) signaling pathway is conserved in animals as diverse as fruit flies and humans. This pathway is involved in embryological development, and activation of the pathway in adult tissues ...
Learn More
Vladimir Spiegelman, Neehar Bhatia | P07243US02

Technology

Induced Pluripotent Stem Cell Lines For Fragile X Research

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untranslated ...
Learn More
Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US02

Technology

Plasmids And Cell Lines Expressing The DMPK 3'UTR

The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
Learn More
Mani Mahadevan, Jeffrey Amack | P210221US01

Technology

Insertion Sequence-free Bacteria

A bacteria lacking genomic and non-genomic IS elements is provided. The bacteria may be more stable and useful for the production of amino acids, polypeptides, nucleic acids and other products.
Learn More
Frederick Blattner, John Campbell, David Frisch, Guy Plunkett III, Gyorgy Posfai | P06424US

WARF