UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previous...
Learn More

The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
Learn More

UW researchers have developed modified genetically encoded plasma membrane voltage probes for monitoring mitochondrial and ER membrane voltage gradients. A fluorescence protein tag was coupled with a ...
Learn More

UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.   
Learn More

A UW-Madison researcher has developed a rabbit polyclonal antibody for methylated PKM2. There are three PKM2 arginine methylation sites R445, R447, R455. The antibody was generated using peptides enco...
Learn More

UW-Madison researchers have developed a CRISPR-based genome editing tool to study and modify PULs in B. uniformis. The B. uniformis PULs show distinct glycan-degrading functions and transcriptional co...
Learn More

A UW-Madison researcher has developed and characterized an anti-RBM20 polyclonal antibody rabbit preparation (which he calls the “RBM20 antibody”). The inventor expressed and purified the ...
Learn More

UW-Madison researchers disclose two mutant Bacteroides strains, BU ΔPUL18 and BU ΔPUL37, each with characteristics that could be useful in modulating the gut microbiome.
Learn More

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated B6.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is ...
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is...
Learn More

UW-Madison researchers have developed a transgenic mouse, designated Tg73.7, that carries full-length copies of a human genomic clone of wild-type GFAP, including all introns and exons.
Learn More

UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm3Mes, that was engineered as a knock-in of the R76H point mutation in the Gfap gene. This is ...
Learn More

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
Learn More

Lactic acid bacteria constitute a large group of Gram-positive bacteria (over 200 species described), of which Lactobacillus is the largest genus in the lactic acid bacteria group. Members of the Lact...
Learn More

Normal vibration of vocal folds (aka vocal cords) depends on the tissue's composition and viscoelasticity. When that composition is altered by scarring or damage, the vibratory functionality of the vo...
Learn More

Described herein is a method of preparing an unbiased library of phage variants,comprising (a) preparing a population of “acceptor phage”; (b) removing an endogenoustarget gene and inserting gene ...
Learn More

The HRV proteases (3C and 2A) and the 3D polymerase have very important functions in virus replication cycle and virus-host interactions and are very intensively investigated for their role in develop...
Learn More

The commercially available E. coli strain BL21 λDE3 is commonly used for inducibly overexpressing recombinant proteins. Many derivatives of BL21 cells have been developed and commercialized, wi...
Learn More

UW Madison researchers' present invention is a set of two, new transgenic mouse multiple myeloma (MM) cell lines. Transgenic mice were developed expressing mutations in RAS pathway genes found in ...
Learn More

UW-Madison researchers have cloned, sequenced and characterized the genome from an isolate of the RV-C45 genotype, and they’ve provided the cDNA for a high titer HRV-C (C45-2A-D41K), as well as ...
Learn More

UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta&rdq...
Learn More

Fibronectin (FN) is a large glycoprotein that plays an important role in the formation of extracellular matrices that are necessary for embryogenesis, tissue renewal, and various pathophysiologic proc...
Learn More

Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
Learn More

Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellu...
Learn More