UW-Madison researchers have developed a microfluidic flow cell for EM sample grid preparation. The two-piece device was designed so that EM substrates (grids or disks) could be placed within a central...
Learn More

UW-Madison researchers have developed an approach capable of identifying numerous (200+) inorganic autocatalytic cycles. Their method combined a comproportionation reaction with an auxiliary oxidation...
Learn More

UW-Madison researchers have developed a phenylglyoxal-based alkyne (PGA) chemical probe exhibits a high specificity towards protein citrullination sites and offers compatibility with various azide-con...
Learn More

UW-Madison researchers disclose an ultrahigh-throughput directed evolution platform. The platform leverages yeast display, a specially designed modular molecular probe, and fluorescence-based cell sor...
Learn More

UW-Madison researchers have created an animal model for studying Wilms Tumor by using Wilms Tumor cells from patients. The researchers reprogrammed the patient tumor cells into induced pluripotent ste...
Learn More

UW-Madison researchers have applied transposon technology to CRISPR-mediated gene targeting to create libraries of genetically modified bacteria displaying differentially expressed genes throughout th...
Learn More

UW-Madison researchers have developed an improved and simpler method for rapidly attaching azide (N3) groups to proteins in solution. Whereas the reaction described in P220072 required an oxidative re...
Learn More

UW-Madison researchers generated a mouse model in which the VENUS reporter and the Small Molecule Assisted Shut-off (SMASh) tag are knocked-in at the C-terminus of the endogenous GATA2 allele. In the ...
Learn More

UW-Madison researchers have developed an enzyme-substrate pair that can be used as a tool for C-terminal thioesterification of proteins and peptides. Their tool is based on E. coli MccB, an E1-like en...
Learn More

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
Learn More

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
Learn More

UW-Madison researchers have developed a novel method for performing highly efficient trans-kingdom genetic conjugation from bacteria to fungi. They further developed the method into a system to kill s...
Learn More

UW-Madison researchers have developed a workflow for identifying microbial strains that are effective in treating CDI. Using this workflow, they found that the ability for a microbiome (existing or tr...
Learn More

UW-Madison researchers have developed an improved covalent labeling system for use in protein footprinting. The innovation of the present disclosure advances a currently existing technology -- a coval...
Learn More

UW-Madison researchers have developed biomaterials useful for the luminescent-based quantification of recombinant protein production by lactic acid bacteria under a variety of stimuli, via a method th...
Learn More

UW-Madison researchers have developed a method of enriching microbial DNA in a plasma DNA sample for early detection of microbial infection. Previously, this group found that microbial DNA fragments a...
Learn More

UW-Madison researchers have developed an immortalized keratinocyte cell line from the little brown bat (a species that is now endangered). They utilized that cell line to create a model of bat hiberna...
Learn More

UW-Madison researchers have developed monoclonal antibodies to ketamine and monoclonal antibodies to 6-HNK, one of the major metabolites of ketamine. The antibodies are selective enough to bind to the...
Learn More

UW-Madison researchers have developed a method for increasing butyrate production in the gut. The method includes delivering a microbial community that include certain bacteria, yeasts, and other micr...
Learn More

UW-Madison researchers have developed a blood-brain barrier (BBB) model with in vivo-like BBB transcytosis properties using a new method that improves the fidelity of highly selective, cross-barrier ...
Learn More

UW-Madison inventors have developed a new PACE-based platform for rapid discovery of bioactive cyclic peptide protein aggregation inhibitors. By linking cyclic peptide activity to phage reproduction, ...
Learn More

The present invention from UW-Madison and USDA Forest Service Forest Products Lab (FPL) researchers is an automated system for identifying the source of wood in a charcoal product. The inventors emplo...
Learn More

UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
Learn More

A UW-Madison researcher has developed a novel cell line for studying the dynamics of the protein Ist1. They added a HaloTag onto the 3’ end of IST1 in a human RPE1 cell line. This cell lines provide...
Learn More

UW-Madison researchers have developed a set of vectors for expressing nanobodies. The researchers engineered a vector system for transferring nanobodies between bacterial and mammalian expression syst...
Learn More