UW-Madison researchers have developed a method for making CoPPIX. As before, the method leverages E. coli BL21 grown in the presence of iron and cobalt, but with some notable adjustments, including th...
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UW-Madison researchers have developed a novel strain of transgenic mice that expresses human prostate-specific membrane antigen (hPSMA) downstream of a prostate-specific probasin promoter. These mice ...
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A UW-Madison researcher has developed an animal model for bile duct and pancreatic cancers caused by the fusion gene DNAJ-PKAc. He utilized bile duct or pancreas cells and inserted the fusion gene at ...
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UW-Madison researchers, in collaboration with researchers from University of Illinois Chicago, have developed a de novo peptide design strategy that combines organic synthesis, phage display, and mole...
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A UW-Madison researcher has compiled a large collection of Staphylococcus saprophyticus strains from various sources, and the present disclosure refers to a set of 100 clinical human samples from that...
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UW-Madison researchers have developed a new way to select protein and cyclic peptide binders of amyloid-β (Aβ) oligomers. This innovation uses a transcription factor that the inventors previously en...
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UW-Madison researchers have developed a method for differentiation of human pluripotent stem cells (hPSCs) into endothelial cells (ECs) resulting in a model having improved fidelity to BBB gene expres...
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UW-Madison researchers have generated a new human GATA2 deficiency model. The model was generated using CRISPR-Cas9 targeting to deactivate one copy of the GATA2 gene in HUDEP-2 cells. This cell line,...
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UW-Madison researchers have developed and characterized nine murine monoclonal antibody (mAb) reagents that react uniquely with the EC1 (2x), EC2 (2x), EC5 (3x), and EC6 (2x) extracellular cadherin re...
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UW-Madison researchers have developed three novel antibiotic-free plasmid positive selection mechanisms.  1.     Phage repressor protein R: The first system is a derivative of plasmid pSIP411 en...
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UW-Madison researchers developed a novel method and plasmid construct for creating CAR T cells using CRISPR-Cas gene editing. They used a ribonucleic protein complex with guide RNAs and expressed Cas9...
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UW-Madison researchers have developed Phage Gene Manipulation and Profiling, PhageMap, a method for generating barcoded knockout libraries for every gene within a phage genome through homologous recom...
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UW-Madison researchers have discovered two peptides, HLTF;zf-C3HC4 and RO52;zf-C3HC4 (hereafter referred to as the HLTF peptide and the RO52 peptide) which, when tethered to a protein induce degradati...
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UW-Madison researchers previously discovered that Escherichia coli BL21(DE3) and commercially available derivatives of it carry a deletion that results in an in-frame fusion of sufA and sufB genes wit...
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UW-Madison researchers previously discovered that Escherichia coli BL21(DE3) and commercially available derivatives of it carry a deletion that results in an in-frame fusion of sufA and sufB genes wit...
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UW-Madison researchers previously discovered that Escherichia coli BL21(DE3) and commercially available derivatives of it carry a deletion that results in an in-frame fusion of sufA and sufB genes wit...
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UW-Madison researchers have developed a novel photoreceptor specific promoter-enhancer construct that they call “IMPG2 PE1”, which is based on two distinct regulatory sequences of the human Interp...
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The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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A UW-Madison researcher has developed a rat model for studying the dynamic nature of the protein Tau, a protein implicated in numerous neurological diseases including Alzheimer’s and Parkinson’s d...
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A UW researcher developed a method for making humanized mice through the transplantation of free neonatal thymus cells into immune deficient mice. The researcher injected 10 million thymocytes, collec...
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UW-Madison researchers have developed a mouse model (PPCD1-Delta 40) for Posterior Polymorphous Corneal Dystrophy (PPCD).They have also developed second mouse model (see P250382US01 below).
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UW-Madison researchers have developed a mouse model (PPCD1) for Posterior Polymorphous Corneal Dystrophy (PPCD). They have also developed second mouse model (see P250382US02 below).
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UW-Madison researchers have developed a microfluidic flow cell for EM sample grid preparation. The two-piece device was designed so that EM substrates (grids or disks) could be placed within a central...
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UW-Madison researchers have developed an approach capable of identifying numerous (200+) inorganic autocatalytic cycles. Their method combined a comproportionation reaction with an auxiliary oxidation...
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UW-Madison researchers have developed a phenylglyoxal-based alkyne (PGA) chemical probe exhibits a high specificity towards protein citrullination sites and offers compatibility with various azide-con...
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