UW-Madison researchers have developed three novel antibiotic-free plasmid positive selection mechanisms.  1.     Phage repressor protein R: The first system is a derivative of plasmid pSIP411 en...
Learn More

UW-Madison researchers developed a novel method and plasmid construct for creating CAR T cells using CRISPR-Cas gene editing. They used a ribonucleic protein complex with guide RNAs and expressed Cas9...
Learn More

UW-Madison researchers have developed Phage Gene Manipulation and Profiling, PhageMap, a method for generating barcoded knockout libraries for every gene within a phage genome through homologous recom...
Learn More

UW-Madison researchers have discovered two peptides, HLTF;zf-C3HC4 and RO52;zf-C3HC4 (hereafter referred to as the HLTF peptide and the RO52 peptide) which, when tethered to a protein induce degradati...
Learn More

UW-Madison researchers have developed a method for differentiation of human pluripotent stem cells (hPSCs) into endothelial cells (ECs) resulting in a model having improved fidelity to BBB gene expres...
Learn More

UW-Madison researchers previously discovered that Escherichia coli BL21(DE3) and commercially available derivatives of it carry a deletion that results in an in-frame fusion of sufA and sufB genes wit...
Learn More

UW-Madison researchers previously discovered that Escherichia coli BL21(DE3) and commercially available derivatives of it carry a deletion that results in an in-frame fusion of sufA and sufB genes wit...
Learn More

UW-Madison researchers previously discovered that Escherichia coli BL21(DE3) and commercially available derivatives of it carry a deletion that results in an in-frame fusion of sufA and sufB genes wit...
Learn More

UW-Madison researchers have developed a novel photoreceptor specific promoter-enhancer construct that they call “IMPG2 PE1”, which is based on two distinct regulatory sequences of the human Interp...
Learn More

The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
Learn More

A UW-Madison researcher has developed a rat model for studying the dynamic nature of the protein Tau, a protein implicated in numerous neurological diseases including Alzheimer’s and Parkinson’s d...
Learn More

A UW researcher developed a method for making humanized mice through the transplantation of free neonatal thymus cells into immune deficient mice. The researcher injected 10 million thymocytes, collec...
Learn More

UW-Madison researchers have developed a mouse model (PPCD1-Delta 40) for Posterior Polymorphous Corneal Dystrophy (PPCD).They have also developed second mouse model (see P250382US01 below).
Learn More

UW-Madison researchers have developed a mouse model (PPCD1) for Posterior Polymorphous Corneal Dystrophy (PPCD). They have also developed second mouse model (see P250382US02 below).
Learn More

UW-Madison researchers have developed a microfluidic flow cell for EM sample grid preparation. The two-piece device was designed so that EM substrates (grids or disks) could be placed within a central...
Learn More

UW-Madison researchers have developed an approach capable of identifying numerous (200+) inorganic autocatalytic cycles. Their method combined a comproportionation reaction with an auxiliary oxidation...
Learn More

UW-Madison researchers have developed a phenylglyoxal-based alkyne (PGA) chemical probe exhibits a high specificity towards protein citrullination sites and offers compatibility with various azide-con...
Learn More

UW-Madison researchers disclose an ultrahigh-throughput directed evolution platform. The platform leverages yeast display, a specially designed modular molecular probe, and fluorescence-based cell sor...
Learn More

UW-Madison researchers have created an animal model for studying Wilms Tumor by using Wilms Tumor cells from patients. The researchers reprogrammed the patient tumor cells into induced pluripotent ste...
Learn More

UW-Madison researchers have applied transposon technology to CRISPR-mediated gene targeting to create libraries of genetically modified bacteria displaying differentially expressed genes throughout th...
Learn More

UW-Madison researchers have developed an improved and simpler method for rapidly attaching azide (N3) groups to proteins in solution. Whereas the reaction described in P220072 required an oxidative re...
Learn More

UW-Madison researchers generated a mouse model in which the VENUS reporter and the Small Molecule Assisted Shut-off (SMASh) tag are knocked-in at the C-terminus of the endogenous GATA2 allele. In the ...
Learn More

UW-Madison researchers have developed an enzyme-substrate pair that can be used as a tool for C-terminal thioesterification of proteins and peptides. Their tool is based on E. coli MccB, an E1-like en...
Learn More

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
Learn More

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
Learn More