UW-Madison researchers have developed a novel photoreceptor specific promoter-enhancer construct that they call “IMPG2 PE1”, which is based on two distinct regulatory sequences of the human Interp...
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The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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A UW-Madison researcher has developed a rat model for studying the dynamic nature of the protein Tau, a protein implicated in numerous neurological diseases including Alzheimer’s and Parkinson’s d...
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A UW researcher developed a method for making humanized mice through the transplantation of free neonatal thymus cells into immune deficient mice. The researcher injected 10 million thymocytes, collec...
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UW-Madison researchers have developed a mouse model (PPCD1-Delta 40) for Posterior Polymorphous Corneal Dystrophy (PPCD).They have also developed second mouse model (see P250382US01 below).
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UW-Madison researchers have developed a mouse model (PPCD1) for Posterior Polymorphous Corneal Dystrophy (PPCD). They have also developed second mouse model (see P250382US02 below).
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UW-Madison researchers have developed a microfluidic flow cell for EM sample grid preparation. The two-piece device was designed so that EM substrates (grids or disks) could be placed within a central...
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UW-Madison researchers have developed an approach capable of identifying numerous (200+) inorganic autocatalytic cycles. Their method combined a comproportionation reaction with an auxiliary oxidation...
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UW-Madison researchers have developed a phenylglyoxal-based alkyne (PGA) chemical probe exhibits a high specificity towards protein citrullination sites and offers compatibility with various azide-con...
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UW-Madison researchers disclose an ultrahigh-throughput directed evolution platform. The platform leverages yeast display, a specially designed modular molecular probe, and fluorescence-based cell sor...
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UW-Madison researchers have created an animal model for studying Wilms Tumor by using Wilms Tumor cells from patients. The researchers reprogrammed the patient tumor cells into induced pluripotent ste...
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UW-Madison researchers have applied transposon technology to CRISPR-mediated gene targeting to create libraries of genetically modified bacteria displaying differentially expressed genes throughout th...
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UW-Madison researchers have developed an improved and simpler method for rapidly attaching azide (N3) groups to proteins in solution. Whereas the reaction described in P220072 required an oxidative re...
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UW-Madison researchers generated a mouse model in which the VENUS reporter and the Small Molecule Assisted Shut-off (SMASh) tag are knocked-in at the C-terminus of the endogenous GATA2 allele. In the ...
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UW-Madison researchers have developed an enzyme-substrate pair that can be used as a tool for C-terminal thioesterification of proteins and peptides. Their tool is based on E. coli MccB, an E1-like en...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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UW-Madison researchers have developed a novel method for performing highly efficient trans-kingdom genetic conjugation from bacteria to fungi. They further developed the method into a system to kill s...
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UW-Madison researchers have developed a workflow for identifying microbial strains that are effective in treating CDI. Using this workflow, they found that the ability for a microbiome (existing or tr...
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UW-Madison researchers have developed an improved covalent labeling system for use in protein footprinting. The innovation of the present disclosure advances a currently existing technology -- a coval...
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UW-Madison researchers have developed biomaterials useful for the luminescent-based quantification of recombinant protein production by lactic acid bacteria under a variety of stimuli, via a method th...
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UW-Madison researchers have developed a method of enriching microbial DNA in a plasma DNA sample for early detection of microbial infection. Previously, this group found that microbial DNA fragments a...
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UW-Madison researchers have developed an immortalized keratinocyte cell line from the little brown bat (a species that is now endangered). They utilized that cell line to create a model of bat hiberna...
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UW-Madison researchers have developed monoclonal antibodies to ketamine and monoclonal antibodies to 6-HNK, one of the major metabolites of ketamine. The antibodies are selective enough to bind to the...
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UW-Madison researchers have developed a method for increasing butyrate production in the gut. The method includes delivering a microbial community that include certain bacteria, yeasts, and other micr...
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