Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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UW-Madison have applied transposon technology to CRISPR-mediated gene targeting to create libraries of genetically modified bacteria displaying differentially expressed genes throughout their genome. ...
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UW-Madison researchers have developed a novel method for performing highly efficient trans-kingdom genetic conjugation from bacteria to fungi. They further developed the method into a system to kill s...
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UW-Madison researchers disclose an ultrahigh-throughput directed evolution platform. The platform leverages yeast display, a specially designed modular molecular probe, and fluorescence-based cell sor...
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UW-Madison researchers have developed a workflow for identifying microbial strains that are effective in treating CDI. Using this workflow, they found that the ability for a microbiome (existing or tr...
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UW-Madison researchers have developed an improved covalent labeling system for use in protein footprinting. The innovation of the present disclosure advances a currently existing technology -- a coval...
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UW-Madison researchers have developed biomaterials useful for the luminescent-based quantification of recombinant protein production by lactic acid bacteria under a variety of stimuli, via a method th...
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UW-Madison researchers have developed a method of enriching microbial DNA in a plasma DNA sample for early detection of microbial infection. Previously, this group found that microbial DNA fragments a...
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UW-Madison researchers have developed an immortalized keratinocyte cell line from the little brown bat (a species that is now endangered). They utilized that cell line to create a model of bat hiberna...
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UW-Madison researchers have developed monoclonal antibodies to ketamine and monoclonal antibodies to 6-HNK, one of the major metabolites of ketamine. The antibodies are selective enough to bind to the...
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UW-Madison researchers have developed a method for increasing butyrate production in the gut. The method includes delivering a microbial community that include certain bacteria, yeasts, and other micr...
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UW-Madison researchers have developed a blood-brain barrier (BBB) model with in vivo-like BBB transcytosis properties using a new method that improves the fidelity of highly selective, cross-barrier ...
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UW-Madison inventors have developed a new PACE-based platform for rapid discovery of bioactive cyclic peptide protein aggregation inhibitors. By linking cyclic peptide activity to phage reproduction, ...
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The present invention from UW-Madison and USDA Forest Service Forest Products Lab (FPL) researchers is an automated system for identifying the source of wood in a charcoal product. The inventors emplo...
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UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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A UW-Madison researcher has developed a novel cell line for studying the dynamics of the protein Ist1. They added a HaloTag onto the 3’ end of IST1 in a human RPE1 cell line. This cell lines provide...
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UW-Madison researchers have developed a set of vectors for expressing nanobodies. The researchers engineered a vector system for transferring nanobodies between bacterial and mammalian expression syst...
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UW-Madison researchers have created an animal model for studying Wilms Tumor by using Wilms Tumor cells from patients. The researchers reprogrammed the patient tumor cells into induced pluripotent ste...
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UW-Madison researchers have developed a petri dish with locking mechanisms for single-handed operations. As cell culture workflows can be sensitive to contamination, single-handed operation allows use...
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UW-Madison researchers have developed methods for identifying nucleic acid sequence information using single molecule measurements that provide simple, information-rich workflows with high sensitivity...
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UW-Madison researchers have developed ferritin-targeting proteolysis targeting chimeras (PROTACs) to establish an iron excess stress inside cancer cells. The PROTAC structure contains oleic acid for b...
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UW-Madison researchers have developed an RNA barcode method to measure transcripts produced under an inducible promoter without the need for deep sequencing. The method involves adding a random RNA ba...
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UW-Madison researchers have developed HeLa cell-adapted Rhinovirus-C (RV-C) variants that induce a strong cytopathic effect and replicate vigorously in HeLa-E8 cells. The inventors had previously show...
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UW-Madison researchers have developed a reporter cell line for identifying compounds that promote endothelial cell differentiation and nitric oxide production and identified four compounds that promot...
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