Wisconsin Alumni Research Foundation

Technology

Probiotic Function Of Human Intelectin

The present disclosure provides for methods providing a pre/probiotic agent to a subject. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria, thereby prom...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont, Federico Rey | P150027US04

Technology

Electronically Activated Strained Alkynes

R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R4 is ab...
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Jennifer Schomaker, Eileen Burke | P170043US02

Technology

Planar High-Speed Molecule Sequencer

A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to th...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P180156US01

Technology

Competent Bacteria

The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation compete...
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Frederick Blattner, Gyorgy Posfai, Christopher Herring, Guy Plunkett III, Jeremy Glasner, Trevor M. Twose | P03080US

Technology

Automated Imaging System For Single Molecules

There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure al...
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David Schwartz, Rodney Runnheim, Daniel Forrest | P02230US

Technology

Non-Displasive Pipette

A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid there...
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David Beebe, David Guckenberger | P160210US01

Technology

Lesion Volume Measurements System

An apparatus for measuring lesion volume, for example, in laboratory animals, provides a mirror box allowing a camera to simultaneously acquire profiles of the lesion along at least two crossing axes ...
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Randall Kimple, Junzhou Chen, Hunter Higby, Ryan Wisth, Kyuhyun Lee, Jeremy Rogers | P190262US02

Technology

Methods And Systems For Transmission And Detection Of Free Radicals

The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
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Juda Shohet, Michael Sussman, Faraz Choudhury, Benjamin Minkoff, Grzegorz Sabat, Joshua Blatz | P170004US02

Technology

High-Density Nucleic Acid Arrays On Polyester Substrates

Described is a method of synthesizing nucleic acids on polyester substrates and the resulting compositions of matter. The method synthesizes nucleic acids from surface hydroxyl initiation points prese...
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David Lynn, Matthew Holden, Matthew Carter, Lloyd Smith | P170367US02

Technology

Hydrogel Compositions For Use In Promoting Tubulogenesis

Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell ...
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William Murphy, Eric Nguyen, Michael Schwartz, Hamisha Ardalani, Matthew Zanotelli, Matthew Parlato, David Belair, William Daly, Ngoc Nhi Le, Stefan Zorn | P140314US02

Technology

Inorganic Coatings For The Enhancement Of Chemical Transfection

Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavi...
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William Murphy, Andrew Khalil, Xiaohua Yu, Krishanu Saha, Jared Carlson-Stevermer, Benjamin Steyer | P150078US01

Technology

Prophage Element-Free Bacteria

The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a com...
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Frederick Blattner, John Campbell, David Frisch, Guy Plunkett III, Gyorgy Posfai | P06424US02

Technology

Electronically Activated Strained Alkynes

Compounds of Formula I: [Image Omitted] wherein: R1 and R1′ are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, ...
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Jennifer Schomaker, Eileen Burke | P170043US03

WARF