Wisconsin Alumni Research Foundation

Technology

Model System for Identifying Anti-Cancer Agents

The Hedgehog (Hh) signaling pathway is conserved in animals as diverse as fruit flies and humans. This pathway is involved in embryological development, and activation of the pathway in adult tissues ...
Learn More
Vladimir Spiegelman, Neehar Bhatia | P07243US02

Technology

Induced Pluripotent Stem Cell Lines For Fragile X Research

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untranslated ...
Learn More
Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US02

Technology

Plasmids And Cell Lines Expressing The DMPK 3'UTR

The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
Learn More
Mani Mahadevan, Jeffrey Amack | P210221US01

Technology

Microbial Glycans As A Target Of Human Intelectin

The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
Learn More
Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont | P150027US02

Technology

Probiotic Function Of Human Intelectin

The present disclosure provides for methods providing a pre/probiotic agent to a subject. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria, thereby prom...
Learn More
Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont, Federico Rey | P150027US04

Technology

Electronically Activated Strained Alkynes

R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R4 is ab...
Learn More
Jennifer Schomaker, Eileen Burke | P170043US02

Technology

Planar High-Speed Molecule Sequencer

A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to th...
Learn More
Robert Blick, Abhishek Bhat, Paul Gwozdz | P180156US01

Technology

Competent Bacteria

The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation compete...
Learn More
Frederick Blattner, Gyorgy Posfai, Christopher Herring, Guy Plunkett III, Jeremy Glasner, Trevor M. Twose | P03080US

Technology

Automated Imaging System For Single Molecules

There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure al...
Learn More
David Schwartz, Rodney Runnheim, Daniel Forrest | P02230US

Technology

Non-Displasive Pipette

A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid there...
Learn More
David Beebe, David Guckenberger | P160210US01

Technology

Lesion Volume Measurements System

An apparatus for measuring lesion volume, for example, in laboratory animals, provides a mirror box allowing a camera to simultaneously acquire profiles of the lesion along at least two crossing axes ...
Learn More
Randall Kimple, Junzhou Chen, Hunter Higby, Ryan Wisth, Kyuhyun Lee, Jeremy Rogers | P190262US02

WARF