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317 Results for 'Research Tools'
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Technology
Induced Pluripotent Stem Cell Lines for Fragile X Syndrome Research
Fragile X syndrome (FXS) is a genetic disorder characterized by mild to moderate intellectual disability and a characteristic phenotype. It is the most common form of inherited intellectual disability...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US01
Technology
Induced Pluripotent Stem Cell Lines for Down Syndrome Research
Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
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Anita Bhattacharyya Consigny, Su-Chun Zhang | P160139US01
Technology
3T3-L1 Mouse PGC-1 Alpha Overexpression for Studying Mitochondrial Function and Aging
Mitochondrial function plays a central role in longevity and healthy aging, and delayed aging by calorie restriction activates PGC-1a (peroxisome proliferator-activated receptor gamma coactivator-1 al...
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Rozalyn Anderson, Samantha Wright, Stephen Martin, Porsha Howell, Josef Clark, Karl Miller | P200143US01
Technology
Model System for Identifying Anti-Cancer Agents
The Hedgehog (Hh) signaling pathway is conserved in animals as diverse as fruit flies and humans. This pathway is involved in embryological development, and activation of the pathway in adult tissues ...
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Vladimir Spiegelman, Neehar Bhatia | P07243US02
Technology
Induced Pluripotent Stem Cell Lines For Fragile X Research
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untranslated ...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US02
Technology
Plasmids And Cell Lines Expressing The DMPK 3'UTR
The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
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Mani Mahadevan, Jeffrey Amack | P210221US01
Technology
Fluorescent-Tagged Moraxella Catarrhalis For Cell Culture Experiments
The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
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Cameron Currie, Reed Stubbendieck | P210244US01
Technology
Generation Of Mice Carrying A Genomic Alteration In The Polg Gene That Leads To Accelerated Aging
A mouse model for mammalian aging is disclosed. In one embodiment, the invention comprises a mouse having a genomic mutation in the exonuclease domain II (ExoII) of a mitochondrial DNA polymerase gamm...
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Tomas Prolla, Gregory Kujoth | P04229US
Technology
Systems And Methods For Determining Genotypes For Performing Physiological Functions
Systems and methods for determining genetic variations of an organism for performing a physiological function. The systems include a number of modules that can be integrated into existing metabolic en...
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Jennifer Reed, Christopher Tervo | P140140US03
Technology
Microbial Glycans As A Target Of Human Intelectin
The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont | P150027US02
Technology
Probiotic Function Of Human Intelectin
The present disclosure provides for methods providing a pre/probiotic agent to a subject. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria, thereby prom...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont, Federico Rey | P150027US04
Technology
Systems And Methods For Determining Flux Distribution
Provided are systems and methods for accurately determining flux distribution in organisms or cells without use of metabolic flux analysis data. The methods include estimating flux distributions in mu...
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Jennifer Reed, Matthew Long | P140300US02
Technology
Electronically Activated Strained Alkynes
R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R4 is ab...
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Jennifer Schomaker, Eileen Burke | P170043US02
Technology
Planar High-Speed Molecule Sequencer
A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to th...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P180156US01
Technology
Competent Bacteria
The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation compete...
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Frederick Blattner, Gyorgy Posfai, Christopher Herring, Guy Plunkett III, Jeremy Glasner, Trevor M. Twose | P03080US
Technology
Computer Systems For Annotation Of Single Molecule Fragments
There are provided computer systems for visualizing and annotating single molecule images. Annotation systems in accordance with this disclosure allow a user to mark and annotate single molecules of i...
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David Schwartz, Jessica Severin | P02229US
Technology
Automated Imaging System For Single Molecules
There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure al...
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David Schwartz, Rodney Runnheim, Daniel Forrest | P02230US
Technology
Rna Monomers Containing O-Acetal Levulinyl Ester Groups And Their Use In Rna Microarrays
The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorpo...
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Franco Cerrina, Debbie Mitra, Jeremy Lackey, Masad Damha, Marvin Wickens, Mark Somoza | P08382US03
Technology
System, Process And Software Arrangement For Disease Detection Using Genome Wide Haplotype Maps
System, process and software arrangement produces high resolution, high accuracy, ordered, genome wide haplotyped maps from single molecule based approximate ordered maps and the location of genes res...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US04
Technology
Immunoaffinity Chromatography Using Epitope Tags To Polyol-responsive Monoclonal Antibodies
Disclosed is a method of isolating, purifying, or concentrating a target compound. The method includes the steps of onjugating the target compound to an epitope for a polyol-responsive monoclonal anti...
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Richard Burgess, Nancy Thompson, Sarah Duellman | P04290US
Technology
Non-Displasive Pipette
A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid there...
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David Beebe, David Guckenberger | P160210US01
Technology
System And Process For Validating, Aligning And Reordering One Or More Genetic Sequence Maps Using A
A method and system are provided for comparing ordered segments of a first DNA restriction map with ordered segments of a second DNA restriction map to determine a level of accuracy the first DNA map ...
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David Schwartz, Marco Antoniotti, Bud Mishra, Tom Anantharaman, Salvatore Paxia | P04027US
Technology
Lesion Volume Measurements System
An apparatus for measuring lesion volume, for example, in laboratory animals, provides a mirror box allowing a camera to simultaneously acquire profiles of the lesion along at least two crossing axes ...
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Randall Kimple, Junzhou Chen, Hunter Higby, Ryan Wisth, Kyuhyun Lee, Jeremy Rogers | P190262US02
Technology
Method To Enhance Screening For Homologous Recombination In Genome Edited Cells Using Recombination-Activated Fluorescent Donor Delivery Vector
Constructs, vectors, and methods for enhancing homology directed repair using the CRISPR/Cas9 gene editing platform are disclosed.
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Mark Burkard, David Thompson | P180200US02
Technology
Petri Dish With Single-Handed Lid Connection And Removal
A petri dish has interlock features between the lid and dish that allow single-handed engagement of the lid with the dish by rotation, so that the lid and dish may be raised by grasping only the lid w...
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Aleksandar Wood, Harpreet Singh | P190121US02