Wisconsin Alumni Research Foundation

Technology

Microbial Glycans As A Target Of Human Intelectin

The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont | P150027US02

Technology

Non-Displasive Pipette

A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid there...
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David Beebe, David Guckenberger | P160210US01

Technology

Electronically Activated Strained Alkynes

R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R4 is ab...
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Jennifer Schomaker, Eileen Burke | P170043US02

Technology

Planar High-Speed Molecule Sequencer

A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to th...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P180156US01

Technology

Competent Bacteria

The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation compete...
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Frederick Blattner, Gyorgy Posfai, Christopher Herring, Guy Plunkett III, Jeremy Glasner, Trevor M. Twose | P03080US

Technology

Hydrogel Compositions For Use In Promoting Tubulogenesis

Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell ...
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William Murphy, Eric Nguyen, Michael Schwartz, Hamisha Ardalani, Matthew Zanotelli, Matthew Parlato, David Belair, William Daly, Ngoc Nhi T. Le, Stefan Zorn | P140314US02

Technology

Electronically Activated Strained Alkynes

Compounds of Formula I: [Image Omitted] wherein: R1 and R1′ are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, ...
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Jennifer Schomaker, Eileen Burke | P170043US03

Technology

High-Density Nucleic Acid Arrays On Polyester Substrates

Described is a method of synthesizing nucleic acids on polyester substrates and the resulting compositions of matter. The method synthesizes nucleic acids from surface hydroxyl initiation points prese...
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David Lynn, Matthew Holden, Matthew Carter, Lloyd Smith | P170367US02

Technology

Methods And Systems For Transmission And Detection Of Free Radicals

The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
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J. Leon Shohet, Michael Sussman, Faraz Choudhury, Benjamin Minkoff, Grzegorz Sabat, Joshua Blatz | P170004US02

Technology

A Method To Determine The Throughput Speed Of A Pore

A method (100) can be provided to determine the throughput speed v of at least one pore (1), comprising: • feeding (110), using a driving force F, a filiform calibration element (2) through the pore...
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Robert Blick, Paul Gwozdz, Abhishek Bhat | P160202US02

Technology

System And Method For En Masse Patterning Of Molecule Structures

Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be con...
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David Schwartz, Kristy Kounovsky-Shafer, Juan Hernandez-Ortiz, Konstantinos Potamousis, Kyubong Jo, Juan DePablo, Theo Odijk | P170209US02

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