Wisconsin Alumni Research Foundation

Technology

Methods And Systems For Transmission And Detection Of Free Radicals

The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
Learn More
Juda Shohet, Michael Sussman, Faraz Choudhury, Benjamin Minkoff, Grzegorz Sabat, Joshua Blatz | P170004US02

Technology

High-Density Nucleic Acid Arrays On Polyester Substrates

Described is a method of synthesizing nucleic acids on polyester substrates and the resulting compositions of matter. The method synthesizes nucleic acids from surface hydroxyl initiation points prese...
Learn More
David Lynn, Matthew Holden, Matthew Carter, Lloyd Smith | P170367US02

Technology

Hydrogel Compositions For Use In Promoting Tubulogenesis

Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell ...
Learn More
William Murphy, Eric Nguyen, Michael Schwartz, Hamisha Ardalani, Matthew Zanotelli, Matthew Parlato, David Belair, William Daly, Ngoc Nhi Le, Stefan Zorn | P140314US02

Technology

Inorganic Coatings For The Enhancement Of Chemical Transfection

Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavi...
Learn More
William Murphy, Andrew Khalil, Xiaohua Yu, Krishanu Saha, Jared Carlson-Stevermer, Benjamin Steyer | P150078US01

Technology

Electronically Activated Strained Alkynes

Compounds of Formula I: [Image Omitted] wherein: R1 and R1′ are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, ...
Learn More
Jennifer Schomaker, Eileen Burke | P170043US03

Technology

Sensor For Cyanuric Acid Detection

A cyanuric acid-responsive biosensor includes a host strain or cell-free system including a first and a second expression cassette; the first expression cassette including, in operable communication, ...
Learn More
Srivatsan Raman, Xiangyang Liu | P180322US02

Technology

System And Method For En Masse Patterning Of Molecule Structures

Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be con...
Learn More
David Schwartz, Kristy Kounovsky-Shafer, Juan Hernandez-Ortiz, Konstantinos Potamousis, Kyubong Jo, Juan DePablo, Theo Odijk | P170209US02

Technology

A Method To Determine The Throughput Speed Of A Pore

A method (100) can be provided to determine the throughput speed v of at least one pore (1), comprising: • feeding (110), using a driving force F, a filiform calibration element (2) through the pore...
Learn More
Robert Blick, Paul Gwozdz, Abhishek Bhat | P160202US02

Technology

Artificial Transcription Factors and Uses Thereof

Transcription factor expression can profoundly alter the transcriptional dynamics of a cell, even inducing the transition to a new cell fate. Four transcription factors – Oct4, Sox2, Klf4, and c-Myc...
Learn More
Aseem Ansari, Asuka Eguchi | P160383US02

Technology

Nanocapsule Delivery System For Ribonucleoproteins

With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
Learn More
Shaoqin Gong, Krishanu Saha, Guojun Chen, Amr Abdeen, Yuyuan Wang, Ruosen Xie | P170376US02

Technology

Nuclease Inhibitors and Methods for Their Use

Biochemical research and biotechnology rely on nucleic acids; however, nucleic acids frequently encounter nucleases that can negatively affect experiments. Although nuclease inhibitors are often used ...
Learn More
Ronald Raines, Bryan Smith, David Lynn, Matthew Soellner | P05096US

Technology

S1mplex: A New Tool for Precision Gene Editing

New tools for human gene editing are rapidly advancing all sectors of biomedicine from basic biology to somatic gene therapy in the clinic. Precise editing of DNA sequences in the human genome can be ...
Learn More
Krishanu Saha, Jared Carlson-Stevermer, Amr Abdeen, Lucille Kohlenberg | P170309US02

WARF