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323 Results for 'Research Tools'
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Technology
Mouse Model of Alexander Disease (Model FVB.129S7 (Cg) Gfap tm2Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is...
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Albee Messing, Tracy Hagemann | P220165US01
Technology
Transgenic Mouse Expressing Human GFAP (Model Tg73.7)
UW-Madison researchers have developed a transgenic mouse, designated Tg73.7, that carries full-length copies of a human genomic clone of wild-type GFAP, including all introns and exons.
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Albee Messing, Michael Brenner | P220166US01
Technology
Mouse Model of Alexander Disease (Model FVB.129S7 (Cg) Gfap tm3Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm3Mes, that was engineered as a knock-in of the R76H point mutation in the Gfap gene. This is ...
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Albee Messing, Tracy Hagemann | P220169US01
Technology
Mouse Models for Protein Granule Diseases
Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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Wei Guo | P210193US01
Technology
A Novel Counter-Selection Marker for Use in Lactic Acid Bacteria
Lactic acid bacteria constitute a large group of Gram-positive bacteria (over 200 species described), of which Lactobacillus is the largest genus in the lactic acid bacteria group. Members of the Lact...
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Jan Peter Van Pijkeren, Jeehwan Oh | P160379US01
Technology
Immortalized Vocal Fold Fibroblasts
Normal vibration of vocal folds (aka vocal cords) depends on the tissue's composition and viscoelasticity. When that composition is altered by scarring or damage, the vibratory functionality of th...
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Susan Thibeault, Xia Chen | P190232US01
Technology
Methods Of Making Unbiased Phage Libraries
Described herein is a method of preparing an unbiased library of phage variants,comprising (a) preparing a population of “acceptor phage”; (b) removing an endogenoustarget gene and inserting gene ...
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Srivatsan Raman, Phil Huss | P200126US02
Technology
Rabbit Polyclonal Antibodies Against HRV-A16 (Human Rhinovirus, Species A, Strain 16) Proteins 2A Protease, 3C Protease and 3D Polymerase
The HRV proteases (3C and 2A) and the 3D polymerase have very important functions in virus replication cycle and virus-host interactions and are very intensively investigated for their role in develop...
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Ann Palmenberg, James Gern, Svetlana Amineva, Aleksey Aminev | P210172US01
Technology
SufFeSient Cells
The commercially available E. coli strain BL21 λDE3 is commonly used for inducibly overexpressing recombinant proteins. Many derivatives of BL21 cells have been developed and commercialized, with pro...
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Patricia Kiley, Erin Mettert | P190138US01
Technology
Vq Myeloma Cell Lines
UW Madison researchers' present invention is a set of two, new transgenic mouse multiple myeloma (MM) cell lines. Transgenic mice were developed expressing mutations in RAS pathway genes found in ...
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Jing Zhang | P210035US01
Technology
PLASMID ENCODING INFECTIOUS RHINOVIRUS-C GENOTYPE C45
UW-Madison researchers have cloned, sequenced and characterized the genome from an isolate of the RV-C45 genotype, and they’ve provided the cDNA for a high titer HRV-C (C45-2A-D41K), as well as the ...
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Ann Palmenberg | P210398US01
Technology
RPE CELL LINES WITH PLK4 CONDITIONAL KNOCKOUT AND ANALOG SENSITIVE MUTATION
UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta” is a...
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Mark Burkard, Ryan Denu | P210364US01
Technology
Murine Monoclonal Antibodies to N-terminal FN1 Modules of Fibronectin
Fibronectin (FN) is a large glycoprotein that plays an important role in the formation of extracellular matrices that are necessary for embryogenesis, tissue renewal, and various pathophysiologic proc...
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Deane Mosher, Douglas Annis | P190347US01
Technology
Human Basal Cell Carcinoma Cell Line UW-BCC1
Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
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Vladimir Spiegelman, Felicite Noubissi Kamdem | P140339US01
Technology
CHO Cell Line Expressing HERG-1 Potassium Channels
HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US
Technology
Kras Conditional Knockout Allele
Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellu...
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Jing Zhang | P210181US01
Technology
GATA2-Mutant Cells to Enable Cancer, Immunology, and Hematology Discoveries
GATA-binding-factor 2 (GATA2) is a transcription factor involved in stem cell maintenance and hematopoietic development. The gene encoding GATA2 often suffers germline and somatic mutations, which res...
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Emery Bresnick, Koichi Katsumura, Kirby Johnson | P200065US01
Technology
SARS-CoV-2 Polymerase Production
Coronaviruses are a group of RNA viruses that can cause disease. Some, such as the common cold, can cause mild disease, while others, such as COVID-19, can be lethal. An unusual characteristic of coro...
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Robert Kirchdoerfer | P210033US01
Technology
Induced Pluripotent Stem Cell Lines for Fragile X Syndrome Research
Fragile X syndrome (FXS) is a genetic disorder characterized by mild to moderate intellectual disability and a characteristic phenotype. It is the most common form of inherited intellectual disability...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US01
Technology
Induced Pluripotent Stem Cell Lines for Down Syndrome Research
Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
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Anita Bhattacharyya Consigny, Su-Chun Zhang | P160139US01
Technology
3T3-L1 Mouse PGC-1 Alpha Overexpression for Studying Mitochondrial Function and Aging
Mitochondrial function plays a central role in longevity and healthy aging, and delayed aging by calorie restriction activates PGC-1a (peroxisome proliferator-activated receptor gamma coactivator-1 al...
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Rozalyn Anderson, Samantha Wright, Stephen Martin, Porsha Howell, Josef Clark, Karl Miller | P200143US01
Technology
Model System for Identifying Anti-Cancer Agents
The Hedgehog (Hh) signaling pathway is conserved in animals as diverse as fruit flies and humans. This pathway is involved in embryological development, and activation of the pathway in adult tissues ...
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Vladimir Spiegelman, Neehar Bhatia | P07243US02
Technology
Induced Pluripotent Stem Cell Lines For Fragile X Research
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untransla...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US02
Technology
Fluorescent-Tagged Moraxella Catarrhalis For Cell Culture Experiments
The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
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Cameron Currie, Reed Stubbendieck | P210244US01
Technology
Plasmids And Cell Lines Expressing The DMPK 3'UTR
The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs ...
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Mani Mahadevan, Jeffrey Amack | P210221US01