Wisconsin Alumni Research Foundation

Technology

GENETIC TOOLS FOR THE ENGINEERING OF BACTEROIDES

UW-Madison researchers have developed a CRISPR-based genome editing tool to study and modify PULs in B. uniformis. The B. uniformis PULs show distinct glycan-degrading functions and transcriptional co...
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Ophelia Venturelli, Jun Feng | P220212US01

Technology

RBM20 ANTIBODY

A UW-Madison researcher has developed and characterized an anti-RBM20 polyclonal antibody rabbit preparation (which he calls the “RBM20 antibody”). The inventor expressed and purified the ...
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Wei Guo, Marion Greaser | P220238US01

Technology

Knockout of GFAP In the Mouse (Model tm1Mes)

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01

Technology

Mouse Models for Protein Granule Diseases

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
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Wei Guo | P210193US01

Technology

Immortalized Vocal Fold Fibroblasts

Normal vibration of vocal folds (aka vocal cords) depends on the tissue's composition and viscoelasticity. When that composition is altered by scarring or damage, the vibratory functionality of the vo...
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Susan Thibeault, Xia Chen | P190232US01

Technology

Methods Of Making Unbiased Phage Libraries

Described herein is a method of preparing an unbiased library of phage variants,comprising (a) preparing a population of “acceptor phage”; (b) removing an endogenoustarget gene and inserting gene ...
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Srivatsan Raman, Phil Huss | P200126US02

Technology

SufFeSient Cells

The commercially available E. coli strain BL21 λDE3 is commonly used for inducibly overexpressing recombinant proteins. Many derivatives of BL21 cells have been developed and commercialized, wi...
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Patricia Kiley, Erin Mettert | P190138US01

Technology

Vq Myeloma Cell Lines

UW Madison researchers' present invention is a set of two, new transgenic mouse multiple myeloma (MM) cell lines. Transgenic mice were developed expressing mutations in RAS pathway genes found in ...
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Jing Zhang | P210035US01

Technology

Human Basal Cell Carcinoma Cell Line UW-BCC1

Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
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Vladimir Spiegelman, Felicite Noubissi Kamdem | P140339US01

Technology

Kras Conditional Knockout Allele

Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellu...
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Jing Zhang | P210181US01

Technology

CHO Cell Line Expressing HERG-1 Potassium Channels

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US

Technology

SARS-CoV-2 Polymerase Production

Coronaviruses are a group of RNA viruses that can cause disease. Some, such as the common cold, can cause mild disease, while others, such as COVID-19, can be lethal. An unusual characteristic of coro...
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Robert Kirchdoerfer | P210033US01

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