In animals, plants and other eukaryotic organisms, typically one protein is translated from each mRNA. Usually, translation can start only at one end of the mRNA strand. In contrast, several viruses ...
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Su-Chun Zhang, a world-renowned neuroscientist and pioneer in stem cell research, has developed a method for printing neural tissues that allows cells to form neural networks in vitro. The human brain...
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Pyruvate is a starting material for synthesizing a variety of biofuels and chemicals. It can be readily converted into more than 60 commercial chemicals, including ethanol and several active pharmaceu...
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Boronic acids (i.e., compounds that have a single boron-carbon bond) are one of the most useful functional groups in organic chemistry and chemical biology. They have applications in polymer sciences,...
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Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Interspecies yeast hybrids are critical for producing commercially important fermentation products such as Belgian ale, certain ciders and cold-fermented wines. As one major example, lager beer, the m...
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UW-Madison researchers have developed a number of variants of lytic strain L. reuteri ∆Φ1attB1∆Φ2∆attB2 (WARF case P170020). They are: L. reuteri∆Φ1, in which prophage #1 is deleted from th...
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Catalysts play countless roles in modern society including production of fertilizer, synthesis of plastics and other ubiquitous materials and development of pharmaceuticals. However, many catalysts re...
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In nature, most microbes live in synergistic communities (microbiomes) as a way to thrive in various environments. For example, more than 100 trillion bacteria are estimated to live in the human gut a...
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Proteomics is a relatively new discipline that is a large scale study of proteins. It includes systematically identifying the sequence, characterizing the structure and evaluating the function of all ...
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Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics, or the classification of proteins based on the genome of an organism.  MS ...
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UW-Madison researchers have discovered an entirely new extracellular vesicle (EV), which they have coined pyosomes, that are formed during tumor cell pyroptosis. The inventors developed a workflow (il...
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UW-Madison researchers have developed a method for making cobalt-substituted protoporphyrins (CoPPIX), which could be useful in improving enzymatic reactions. Their process leverages E. coli BL21, whi...
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UW-Madison researchers have developed a novel strain of transgenic mice that expresses human prostate-specific membrane antigen (hPSMA) downstream of a prostate-specific probasin promoter. These mice ...
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A UW-Madison researcher has developed an animal model for bile duct and pancreatic cancers caused by the fusion gene DNAJ-PKAc. He utilized bile duct or pancreas cells and inserted the fusion gene at ...
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UW-Madison researchers, in collaboration with researchers from University of Illinois Chicago, have developed a de novo peptide design strategy that combines organic synthesis, phage display, and mole...
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A UW-Madison researcher has compiled a large collection of Staphylococcus saprophyticus strains from various sources, and the present disclosure refers to a set of 100 clinical human samples from that...
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UW-Madison researchers have developed a new way to select protein and cyclic peptide binders of amyloid-β (Aβ) oligomers. This innovation uses a transcription factor that the inventors previously en...
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UW-Madison researchers have developed a method for differentiation of human pluripotent stem cells (hPSCs) into endothelial cells (ECs) resulting in a model having improved fidelity to BBB gene expres...
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UW-Madison researchers have generated a new human GATA2 deficiency model. The model was generated using CRISPR-Cas9 targeting to deactivate one copy of the GATA2 gene in HUDEP-2 cells. This cell line,...
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UW-Madison researchers have developed and characterized nine murine monoclonal antibody (mAb) reagents that react uniquely with the EC1 (2x), EC2 (2x), EC5 (3x), and EC6 (2x) extracellular cadherin re...
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UW-Madison researchers have developed three novel antibiotic-free plasmid positive selection mechanisms.  1.     Phage repressor protein R: The first system is a derivative of plasmid pSIP411 en...
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UW-Madison researchers developed a novel method and plasmid construct for creating CAR T cells using CRISPR-Cas gene editing. They used a ribonucleic protein complex with guide RNAs and expressed Cas9...
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UW-Madison researchers have developed Phage Gene Manipulation and Profiling, PhageMap, a method for generating barcoded knockout libraries for every gene within a phage genome through homologous recom...
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