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289 Results for 'Therapeutics & Vaccines'
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Technology
Stable Collagen Mimics
Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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Ronald Raines, Matthew Shoulders, Jonathan Hodges | P06406US
Technology
Global Regulator of Morphogenesis and Pathogenicity in Dimorphic Fungi
Dimorphic fungi are soil-dwelling microorganisms that are harmless in their usual mold form, but once inhaled by a mammal, transform into virulent yeast and cause life threatening illnesses, such as p...
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Bruce Klein, Julie Nemecek, Marcel Wuethrich | P06029US
Technology
Beta-Peptides with Antifungal Activity
Fungal infections, such as infections by the yeast Candida albicans, are a persistent health problem in some patient populations. Topical yeast infections affect the mouth, vagina, skin, stomach and u...
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Samuel Gellman, Sean Palecek, William Pomerantz, Amy Karlsson | P06201US
Technology
Receptor For Bacillus anthracis Toxin
Infection with Bacillus anthracis, the spore-forming causative agent of anthrax, can result in either a generally benign, self-limiting cutaneous disease or a more serious and often fatal systemic dis...
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John Young, Kenneth Bradley, R. John Collier, Jeremy Mogridge | P00305US
Technology
Methods and Compositions for Treating Prostate Cancer with DNA Vaccines
Prostate cancer is the second most common form of cancer among North American men. Current therapies for prostate cancer involve either removing the entire gland or treating it with radiation; however...
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Douglas McNeel | P02376US
Technology
Novel Candidates for an Improved Tuberculosis Vaccine
Approximately one-third of the world’s population is infected with the bacterium Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Five to 10 percent of non-immunocompr...
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Adel Talaat, Bassam Abomoelak, Sarah Ward | P09203US02
Technology
Treating Fibrotic Disorders by Inhibiting BMP-1-Like Proteinases
The formation of collagen fibrils is essential to the healing of wounds and bone fractures. But excessive formation of collagenous, extracellular matrix (ECM) proteins can cause fibrotic disorders, su...
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Daniel Greenspan, Gaoxiang Ge, Yue Zhang | P05169US
Technology
Novel Peptide Adjuvant Improves Response to Influenza Vaccination
Influenza causes widespread morbidity and mortality worldwide. High-risk populations are routinely vaccinated in the United States, but influenza is still responsible for approximately 200,000 hospita...
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Stacey Schultz-Cherry, Curtis Brandt, Jeremy Jones | P08262US
Technology
Strong, Stable, Semisynthetic Collagen Mimic for Wound Healing, Artificial Skin, Sutures and Leather
Collagen is the most abundant protein in vertebrates. It serves as the fundamental structural protein for vertebrate tissues and is critically important in wound healing. Many diseases, including arth...
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Ronald Raines, Frank Kotch | P08274US
Technology
Novel Antiviral Peptides Against Influenza Virus
Influenza viruses cause morbidity and mortality worldwide. In the United States, influenza is responsible for approximately 200,000 hospitalizations and 36,000 deaths each year.
Two classes of antiv...
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Stacey Schultz-Cherry, Curtis Brandt, Jeremy Jones | P08294US
Technology
Novel Antibacterial Small Molecules
As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US
Technology
A New Phosphate Binder for Blocking Phosphate Absorption and Reducing Hyperphosphatemia
The kidney filters toxins and excess nutrients from the blood. It also synthesizes the active form of vitamin D3. In patients with chronic kidney disease, levels of active vitamin D3 decline, leading ...
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Hector DeLuca, Katarzyna Barycka, Katie Williams | P06053US
Technology
Tat-Utrophin as a Protein Therapy for Muscular Dystrophies
No effective therapy currently exists for the most common and severe form of muscular dystrophy disease, Duchenne Muscular Dystrophy (DMD). This disease, which is characterized by the weakening of vol...
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James Ervasti, Kevin Sonnemann | P06414US
Technology
Method for Synthesizing Beta-Polypeptides from Functionalized Beta-Lactam Monomers
Oligomers and polymers comprised of beta-amino acids, known as beta-peptides, can adopt stable secondary structures that mimic natural peptides. These non-natural compounds are resistant to enzymatic ...
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Samuel Gellman, Sarah Lee, Mehmet Ilker, Bernard Weisblum, Shannon Stahl, Denis Kissounko | P06009US