Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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Dimorphic fungi are soil-dwelling microorganisms that are harmless in their usual mold form, but once inhaled by a mammal, transform into virulent yeast and cause life threatening illnesses, such as p...
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Fungal infections, such as infections by the yeast Candida albicans, are a persistent health problem in some patient populations. Topical yeast infections affect the mouth, vagina, skin, stomach and u...
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Infection with Bacillus anthracis, the spore-forming causative agent of anthrax, can result in either a generally benign, self-limiting cutaneous disease or a more serious and often fatal systemic dis...
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Prostate cancer is the second most common form of cancer among North American men. Current therapies for prostate cancer involve either removing the entire gland or treating it with radiation; however...
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Approximately one-third of the world’s population is infected with the bacterium Mycobacterium tuberculosis, the causative agent of tuberculosis (TB).  Five to 10 percent of non-immunocompr...
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The formation of collagen fibrils is essential to the healing of wounds and bone fractures. But excessive formation of collagenous, extracellular matrix (ECM) proteins can cause fibrotic disorders, su...
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Influenza causes widespread morbidity and mortality worldwide. High-risk populations are routinely vaccinated in the United States, but influenza is still responsible for approximately 200,000 hospita...
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Collagen is the most abundant protein in vertebrates. It serves as the fundamental structural protein for vertebrate tissues and is critically important in wound healing. Many diseases, including arth...
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Influenza viruses cause morbidity and mortality worldwide. In the United States, influenza is responsible for approximately 200,000 hospitalizations and 36,000 deaths each year. Two classes of antiv...
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As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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The kidney filters toxins and excess nutrients from the blood. It also synthesizes the active form of vitamin D3. In patients with chronic kidney disease, levels of active vitamin D3 decline, leading ...
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No effective therapy currently exists for the most common and severe form of muscular dystrophy disease, Duchenne Muscular Dystrophy (DMD). This disease, which is characterized by the weakening of vol...
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Oligomers and polymers comprised of beta-amino acids, known as beta-peptides, can adopt stable secondary structures that mimic natural peptides. These non-natural compounds are resistant to enzymatic ...
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