Wisconsin Alumni Research Foundation

Technology

Inhibitors Of Collagen Prolyl 4-Hydroxylase

The invention provides biheteroaryl dicarboxylates and esters, and salts thereof which are useful generally as modulators of CP4H activity, more particularly as inhibitors of CP4H, or further as chemi...
Learn More
Ronald Raines, James Vasta | P150092US02

Technology

Anti-microbial Agents

Antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill targeted ...
Learn More
Marcin Filutowicz | P04023US

Technology

Methods And Compositions For Phosphate Binding

The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administ...
Learn More
Hector DeLuca, Katarzyna Barycka, Lori Plum, Julia Zella, Margaret Clagett-Dame | P08110US

Technology

High-Potency Botulinum Toxin Formulations

The present invention provides improved formulations of botulinum toxin that increase delivery of the botulinum toxin to neural and associated tissues and exhibit a higher specific neurotoxicity and h...
Learn More
Gary Borodic | P08444US01

Technology

2-methylene-20(21)-dehydro-19-nor-vitamin D Analogs

This invention discloses 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-20(21)-dehydro-19-nor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
Learn More
Hector DeLuca, Bulli Padmaja Tadi, Lori Plum, Margaret Clagett-Dame | P08364US

Technology

2-methylene-(20s,25s)-19,26-dinor-vitamin D Analogs

This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
Learn More
Hector DeLuca, Lori Plum, Margaret Clagett-Dame, Grazia Chiellini, Pawel Grzywacz | P08089US

Technology

2-methylene-(20s,25r)-19,26-dinor-vitamin D Analogs

This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
Learn More
Hector DeLuca, Lori Plum, Margaret Clagett-Dame, Grazia Chiellini, Pawel Grzywacz | P08090US

Technology

2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D Analogs

This invention discloses 2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs, and specifically 2-methylene-20-methyl-1α-hydroxy-19,24,25,26,27-pentanor-vitamin D3, and pharmaceutical uses...
Learn More
Hector DeLuca, Lori Plum, Agnieszka Glebocka, Margaret Clagett-Dame, Rafal Sicinski | P08106US

Technology

2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin D Analogs

This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefo...
Learn More
Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Grazia Chiellini, Pawel Grzywacz | P07107US

Technology

19,26,27-trinor-1alpha,25-dihydroxyvitamin D3 Compounds

This invention relates to vitamin D compounds, and more particularly to 19,26,27-trinor-1α,25-dihydroxyvitamin D3 compounds such as 2α-methyl-19,26,27-trinor-(20S)-1α,25-dihydroxyvitamin D3 (“P...
Learn More
Hector DeLuca, Lori Plum, Pawel Grzywacz, Margaret Clagett-Dame | P05370US

Technology

17,20(z)-dehydro Vitamin D Analogs And Their Uses

This invention discloses 17,20(Z)-dehydro vitamin D analogs, and specifically 17(Z)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibi...
Learn More
Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Bulli Padmaja Tadi | P06097US

Technology

17,20(e)-dehydro Vitamin D Analogs And Their Uses

This invention discloses 17,20(E)-dehydro vitamin D analogs, and specifically 17(E)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibi...
Learn More
Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Bulli Padmaja Tadi | P06117US

WARF