Wisconsin Alumni Research Foundation

Technology

Anti-Apoptotic Vector And Method Of Using The Same

UW Madison researchers' present invention provides vectors for delivery of an anti-apoptotic therapy. The vectors include a phosphoglycerate kinase (Pgk) promoter operably connected to a polynucleotid...
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Robert Nickells, Gillian McLellan, Ryan Donahue | P210046WO01

Technology

Inhibitors Of Bacterial Pasta Kinases

Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
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Robert Striker, Nathan Wlodarchak, John Feltenberger, Jennifer Golden | P180315US02

Technology

CHO Cell Line Expressing HERG-1 Potassium Channels

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US

Technology

COVID-19 Vaccine

Provided herein are antigenic peptides comprising the SARS-CoV-2 spike protein receptor binding domain (CRBD) polypeptide or portions thereof, linked to a non-catalytic, non­toxic tetanus toxin varia...
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Joseph Barbieri, Eric Johnson, Sabine Pellett, William Tepp, Amanda Przedpelski | P200268US03

Technology

RSV Virus-Like Particles And Methods Of Use Thereof

The present disclosure relates to vims-like particles and vaccine compositions for inducing immunity and preventing respiratory syncytial vims (RSV) infection. Specifically, the disclosure provides vi...
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Elizabeth Wright, Larry Anderson, Binh Ha | P200021US02

Technology

2-methylene-19-nor Vitamin D2 Compounds

2-Methylene-19-nor-24(S) and 24(R) derivatives of 1α,25-dihydroxyvitamin D2 are disclosed. These compounds are characterized by minimal bone calcium mobilization activity and relatively high intestin...
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Hector DeLuca, Sumithra Gowlugari, Rafal Sicinski | P02026US

Technology

2-methylene-(20s,25r)-19,26-dinor-vitamin D Analogs

This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
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Hector DeLuca, Lori Plum, Margaret Clagett-Dame, Grazia Chiellini, Pawel Grzywacz | P08090US

Technology

Methods For Preventing And Attenuating Hyperphosphatemia

It is disclosed here a method for reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at ris...
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Mark Cook, Keith Crawford, Erica Hellestad, Martin Petkovich, Christian Helvig | P06481US

Technology

19,26,27-trinor-1alpha,25-dihydroxyvitamin D3 Compounds

This invention relates to vitamin D compounds, and more particularly to 19,26,27-trinor-1α,25-dihydroxyvitamin D3 compounds such as 2α-methyl-19,26,27-trinor-(20S)-1α,25-dihydroxyvitamin D3 (“P...
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Hector DeLuca, Lori Plum, Pawel Grzywacz, Margaret Clagett-Dame | P05370US

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