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272 Results for 'Therapeutics & Vaccines'
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Technology
REAGENTS AND METHODS FOR PROMOTING ARTERIAL ENDOTHELIUM DIFFERENTIATION AND NITRIC OXIDE PRODUCTION
UW-Madison researchers have developed a reporter cell line for identifying compounds that promote endothelial cell differentiation and nitric oxide production and identified four compounds that promot...
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James Thomson, Jue Zhang | P230071US02
Technology
VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME
UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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Adel Talaat, Bubacarr Touray | P220343US02
Technology
Derivatives Of Turbinmicin As Antifungal Agents
The present invention from UW-Madison researchers is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly i...
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Timothy Bugni, Weiping Tang, Le Guo, Changgui Zhao, Fan Zhang, Douglas Braun, David Andes, Miao Zhao, Jenna Fossen | P200353US02
Technology
METHODS OF INDUCING CARDIAC CELL PROLIFERATION AND INDUCING HEART REGENERATION
UW-Madison researchers have discovered that inducing expression of the protein LRRC10 in mouse hearts promotes heart regeneration. Neonatal mice have hearts that naturally regenerate for the first wee...
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Ahmed Mahmoud, Timothy Kamp, Youngsook Lee | P230238US02
Technology
IDENTIFICATION AND APPLICATION OF SELECTIVE CELL SURFACE MARKERS AND ADDITIONAL METHODS FOR HUMAN RED/GREEN CONE PHOTORECEPTOR PRECURSOR ENRICHMENT
UW-Madison researchers have discovered a cell-surface marker (CD166) that can be used to distinguish (and purify) cells that are immature (early) cone photoreceptor precursor cells (CPPs), which will ...
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David Gamm, Praveen Joseph Susai Manickam, Michael Phillips, Elizabeth Capowski | P220285US02
Technology
IMPROVED INFLUENZA VIRUS REPLICATION FOR VACCINE DEVELOPMENT
UW-Madison researchers have identified new mutations that promote replication of influenza A viruses to high titers in embryonated chicken eggs and would therefore increase the manufacturing yield for...
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Yoshihiro Kawaoka, Gabriele Neumann, Lizheng Guan | P230109US02
Technology
Washed Platelet Extract
UW-Madison researchers have developed a washed platelet extract with increased platelet growth factor concentration and decreased total protein relative to platelet rich plasma, and methods of making ...
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Jacques Galipeau, Sabrina Brounts, Andrea Pennati | P190172US03
Technology
CRYPTIC PROTEINS EXPRESSED FROM DEFECTIVE VIRAL GENOMES INTERFERE WITH INFLUENZA VIRUS REPLICATION
UW-Madison researchers have developed methods for making and using modified influenza gene products, alone or in combination, to inhibit WT virus replication, to serve as immunostimulatory agents, or ...
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Andrew Mehle, Jordan Ranum, Mitchell Ledwith | P230056US02
Technology
Synthetic IL6-IL1beta Fusion Cytokine For Promoting T Cell Cytotoxic Function, T Cell Proliferation, and Anti-Tumoricidal Activity
UW researchers have created a biological therapeutic that stimulates the immune system to fight solid tumors. The researchers fused the cytokines IL-6 and IL- together to form a bifunctional biomol...
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Jacques Galipeau, Rahul Das | P220203US03
Technology
Synthetic Protein For Inducing Immune Tolerance
The present invention from UW Madison researchers is a fusion protein made of the full length PDL-1 transmembrane protein and full length IDO cytosolic protein which the inventors termed PIDO. These t...
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Jacques Galipeau, Pradyut Paul | P200100US02
Technology
MUCOADHESIVE PROBIOTIC BACKPACKS WITH ROS NANO-SCAVENGERS ENHANCE THE BACTERIOTHERAPY FOR INFLAMMATORY BOWEL DISEASES
UW-Madison researchers have developed a novel platform that can selectively and sustainably scavenge ROS in inflamed colon tissues while also improving probiotic delivery for gut microbiota homeostasi...
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Quanyin Hu, Jun Liu | P220262WO01
Technology
UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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Zachary Morris, Justin Jagodinsky | P220308WO01
Technology
Compositions and Methods to Enhance Therapeutic Efficacy of Cancer Therapies
UW researchers have identified a molecule commonly used as a vaccine adjuvant to add to the combination of radiation therapy and checkpoint inhibitor treatment to drive the immune system’s response ...
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Zachary Morris, Justin Jagodinsky | P220308US02
Technology
Synthetic Ligands that Modulate the Activity of the RhlR Quorum Sensing Receptor
UW Madison researchers have developed RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-...
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Helen Blackwell, Joseph Moore, Michelle Boursier | P160350US02
Technology
Methods Of Treating Hypogonadotropic Hypogonadism And Cognition Impairment Following A Traumatic Brain Injury
The UW/VA inventor showed that hCG raises circulating sex hormone levels in a mouse model for TBI as compared to sham treated mice. The data indicated that 1) craniectomy is sufficient to induce persi...
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Craig Atwood | P210252US02
Technology
METHOD FOR SELECTING ANTIGENIC VIRAL VACCINE AND THERAPEUTIC SEQUENCES
UW-Madison researchers, in collaboration with a professor from the University of Missouri, propose using the cryptic lineages (4-24 amino acid substitutions) of the SARS-CoV-2 spike protein sequence t...
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David O'Connor, Thomas Friedrich, Marc Johnson | P230004US02
Technology
SARS-COV-2 LACKING THE ENVELOPE PROTEIN AS AN ATTENUATED VACCINE VIRUS AGAINST COVID-19
UW-Madison researchers have developed a SARS-CoV-2 live-attenuated vaccine virus based on the original Wuhan genome but lacking the envelope (E) open reading frame. This vaccine virus replicates effic...
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Yoshihiro Kawaoka, Peter Halfmann, Makoto Kuroda | P220270WO01
Technology
HYDROGEL COMPOSITIONS COMPRISING GASDERMIN D AND AN ESCRT INHIBITOR AND METHODS OF USE THEREOF
UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small...
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Quanyin Hu, Zhaoting Li | P220290US02
Technology
Generating Allogenic Endothelial Cell-Seeded Vascular Grafts and Methods of Use Thereof
UW-Madison researchers have discovered that using allogenic arterial endothelial cells (not genetically modified to alter the immune response) perform better than hypoimmunogenic cells for producing s...
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James Thomson, Jue Zhang, John Maufort | P220241US02
Technology
Protein Tyrosine Phosphatase 1B Inhibited Neutrophils, Neutrophil-Dendritic Cell Hybrids and Uses Thereof
UW-Madison researchers have developed methods for preparing PTP1b-deficient neutrophils, which exhibit improved recruitment and antimicrobial functions. The inventors employed CRISPR/Cas9 to delete PT...
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Igor Slukvin, Anna Huttenlocher, Morgan Giese, Ho Sun Jung, David Bennin | P220160US03
Technology
Purifying a Clostridium Botulinum Neurotoxin for Therapeutic Use
Clostridium botulinum produces the lethal botulinum neurotoxin (BoNT). There are several types of BoNT, and the subtype BoNT/A1 is used medically to treat muscle movement disorders and cosmetic concer...
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Eric Johnson, William Tepp, Guangyun Lin | P110348US02
Technology
Senolytic CRISPR CAR T Cells Produced By CRISPR-Cas9 Genome Editing
UW Madison researchers have developed a virus-free, CRISPR-Cas mediated method of generating T cells that target senescent cells. These modified T cells could be used to treat Alzheimer’s Disease an...
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Krishanu Saha, Lauren Sarko | P220135US02
Technology
Development of Food-Grade Fungal Fermentates with Antimicrobial Activity
The present invention relates to a ‘sugar fermentate of edible fungi’ (i.e., cultures of GRAS species from the genus Aspergillus) that exhibits antimicrobial activity (e.g., against Listeria monoc...
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Jaehyuk Yu, Ahmad Alshannaq, Dasol Choi | P180291WO01
Technology
Broadly protective influenza B virus vaccines
UW-Madison researchers have developed a series of mutant influenza B viruses that incorporate mutations in the HA1 protein that cause the virus to react with sera generated via exposure to the opposit...
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Yoshihiro Kawaoka, Gabriele Neumann | P220144US02
Technology
MODULAR DENDRON MICELLES FOR TREATMENT OF PULMONARY DISEASES RELATED TO FIBROSIS AND VIRAL INFECTION INCLUDING COVID-19
UW-Madison researchers have developed a dendron-micelle (DM) nanoparticle platform that can be used for combination therapy in the treatment of interstitial lung disease (ILD), including idiopathic pu...
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Seungpyo Hong, Allan Brasier, Weiping Tang | P210069US02