Wisconsin Alumni Research Foundation

Technology

Antibacterial Agents Using Small Molecule Macroarrays

Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US

Technology

Hyperstable Collagen Mimics

Collagen, the most abundant protein in vertebrates, serves as the fundamental structural protein for vertebrate tissues. Collagen is a fibrous protein consisting of three polypeptide chains that fold ...
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Ronald Raines, Jonathan Hodges | P03226US

Technology

Plasmids Encoding Avian Influenza Genes

Avian influenza causes significant economic losses for poultry producers worldwide and can be transmitted to humans and other mammals. The surface glycoproteins hemagglutinin (HA) and neuraminidase (N...
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Yoshihiro Kawaoka | P06123US

Technology

High Titer Recombinant Influenza Viruses for Vaccines

Influenza is caused by the eight-segmented influenza virus. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbersome. To generate reco...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P06370US

Technology

2-Methylene-18,19-Dinor-1Alpha-Hydroxy-Homopregnacalciferol

Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
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Hector DeLuca, Lori Plum, Rafal Barycki, Margaret Clagett-Dame | P05147US

Technology

Cytotoxic Ribonuclease Variants

Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, George Phillips, R. Jeremy Johnson, Jason McCoy | P05341US

Technology

Cytotoxic Ribonuclease Variants

Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, Julie Mitchell, Thomas Rutkoski | P04427US

Technology

Multilayer Tissue Regeneration System

Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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William Murphy | P05256US

Technology

Nanoparticles That Target Dendritic Cells

Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US

Technology

Stable Collagen Mimics

Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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Ronald Raines, Matthew Shoulders, Jonathan Hodges | P06406US

WARF