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272 Results for 'Therapeutics & Vaccines'
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Technology
Antibacterial Agents Using Small Molecule Macroarrays
Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US
Technology
Protein Receptors for Botulinum Neurotoxin E (BoNT/E) Enable Means of Reducing BoNT/E Toxicity
Botulinum neurotoxins (BoNTs), the most potent toxins known, are among the most dangerous potential bioterrorism threats. They cause botulism, a severe disease that can cause paralysis in humans and...
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Edwin Chapman, Min Dong | P08369US02
Technology
Hyperstable Collagen Mimics
Collagen, the most abundant protein in vertebrates, serves as the fundamental structural protein for vertebrate tissues. Collagen is a fibrous protein consisting of three polypeptide chains that fold ...
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Ronald Raines, Jonathan Hodges | P03226US
Technology
Novel Antibacterial Agents That Modulate Quorum Sensing and Are Effective at Physiological pH
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules into the environment. When a certain nu...
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Helen Blackwell, Christine McInnis | P09045US02
Technology
Method to Increase Feed Efficiency by Reducing Endotoxin-Induced GI Tract Inflammation
Pathogenic bacteria in the gastrointestinal tract can induce inflammatory responses that negatively affect the ability of animals to efficiently digest food and absorb nutrients. Endotoxin, a characte...
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Mark Cook, Mingder Yang, David Barnes | P03399US
Technology
Plasmids Encoding Avian Influenza Genes
Avian influenza causes significant economic losses for poultry producers worldwide and can be transmitted to humans and other mammals. The surface glycoproteins hemagglutinin (HA) and neuraminidase (N...
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Yoshihiro Kawaoka | P06123US
Technology
High Titer Recombinant Influenza Viruses for Vaccines
Influenza is caused by the eight-segmented influenza virus. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbersome. To generate reco...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P06370US
Technology
Improved Production of Influenza Virus, Including H1N1, for Vaccine Manufacture
The H1N1 influenza virus, known as the “swine flu,” has been declared a pandemic. While this virus is less virulent than many circulating strains of flu virus, it has become the subject of signi...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P100078US02
Technology
Attenuated Influenza Viruses for Development of Live Influenza Vaccine
Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, influenza vaccines must be adapted almost every year. Live attenuat...
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Yoshihiro Kawaoka, Hatice Akarsu, Kiyoko Horimoto | P09022US02
Technology
Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low molecular weight ligands...
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Helen Blackwell, Grant Geske, Jennifer Campbell Butler | P07404US
Technology
2-Methylene-18,19-Dinor-1Alpha-Hydroxy-Homopregnacalciferol
Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
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Hector DeLuca, Lori Plum, Rafal Barycki, Margaret Clagett-Dame | P05147US
Technology
2-Methylene-19-Nor-1Alpha-Hydroxy-17-Ene-Homopregnacalciferol
Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
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Hector DeLuca, Lori Plum, Bulli Padmaja Tadi, Margaret Clagett-Dame | P05148US
Technology
Glycomacropeptide (GMP)-Based Food for the Treatment of PKU and Other Metabolic Disorders
Phenylketonuria (PKU) is a genetic disorder in which an individual lacks the enzyme phenylalanine hydroxylase (PAH) that converts the amino acid phenylalanine into tyrosine. If left untreated, the b...
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Denise Ney, Mark Etzel | P09323US02
Technology
Cytotoxic Ribonuclease Variants
Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, George Phillips, R. Jeremy Johnson, Jason McCoy | P05341US
Technology
Cytotoxic Ribonuclease Variants
Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, Julie Mitchell, Thomas Rutkoski | P04427US
Technology
Cell Line for Evaluating Influenza Virus Sensitivity to NA Inhibitors
The extensive use of neuraminidase (NA) inhibitors to treat influenza virus infections by reducing viral sialidase activity requires close monitoring for resistant variants. However, cultured cells do...
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Yoshihiro Kawaoka | P05278US
Technology
Multilayer Tissue Regeneration System
Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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William Murphy | P05256US
Technology
Method and System for Delivering Nucleic Acid into a Target Cell
The normal growth and development of tissue requires a complex interplay of multiple signals from multiple genes in well-defined locations, leading to the controlled differentiation of precursor cells...
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William Murphy, Siyoung Choi | P06064US
Technology
Nanoparticles That Target Dendritic Cells
Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US
Technology
Stable Collagen Mimics
Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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Ronald Raines, Matthew Shoulders, Jonathan Hodges | P06406US
Technology
Strong, Stable, Semisynthetic Collagen Mimic for Wound Healing, Artificial Skin, Sutures and Leather
Collagen is the most abundant protein in vertebrates. It serves as the fundamental structural protein for vertebrate tissues and is critically important in wound healing. Many diseases, including arth...
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Ronald Raines, Frank Kotch | P08274US
Technology
Tat-Utrophin as a Protein Therapy for Muscular Dystrophies
No effective therapy currently exists for the most common and severe form of muscular dystrophy disease, Duchenne Muscular Dystrophy (DMD). This disease, which is characterized by the weakening of vol...
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James Ervasti, Kevin Sonnemann | P06414US