Wisconsin Alumni Research Foundation

Technology

Spatial Control of Signal Transduction

Development of most tissue types involves a complex interplay of multiple growth factors in well defined locations, leading to controlled differentiation of precursor cells into mature, tissue-specifi...
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William Murphy, Gregory Hudalla | P05255US

Technology

Cytotoxic Ribonuclease Variants

Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, George Phillips, R. Jeremy Johnson, Jason McCoy | P05341US

Technology

Cytotoxic Ribonuclease Variants

Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, Julie Mitchell, Thomas Rutkoski | P04427US

Technology

Multilayer Tissue Regeneration System

Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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William Murphy | P05256US

Technology

Nanoparticles That Target Dendritic Cells

Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US

Technology

Stable Collagen Mimics

Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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Ronald Raines, Matthew Shoulders, Jonathan Hodges | P06406US

Technology

Novel Candidates for an Improved Tuberculosis Vaccine

Approximately one-third of the world’s population is infected with the bacterium Mycobacterium tuberculosis, the causative agent of tuberculosis (TB).  Five to 10 percent of non-immunocompromised i...
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Adel Talaat, Bassam Abomoelak, Sarah Ward | P09203US02

Technology

Novel Antibacterial Small Molecules

As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US

WARF