Wisconsin Alumni Research Foundation

Technology

Cyclic Peptide-Based Lysosome Targeting Degraders

UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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Weiping Tang, Yaxian Zhou, Yuan Zhao | P220339WO01

Technology

EXTRACELLULAR VESICLE THERAPY TO TREAT ORTHOPEDIC INJURY

UW-Madison researchers have developed methods for using mesenchymal stromal cell (MSC)-derived exosomes to promote ligament and tendon healing, including improvements to the mechanical properties of t...
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Peiman Hematti, Connie Chamberlain, John Kink, Ray Vanderby, Brian Walczak | P230034US02

Technology

Lipid-Peptide Fusion Inhibitors As SARS-CoV-2 Antivirals

UW Madison researchers and collaborators present a method of treating COVID-19 with lipid- peptide fusion antiviral therapy. Also described is a composition and method of treating Ebola with lipid-pep...
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Samuel Gellman, Anne Moscona, Matteo Porotto, Victor Outlaw, Zhen Yu | P200290US02

Technology

Inhibitors Of Encephalitic Alphaviruses

The present invention from UW Madison inventors and collaborators is a set of two distinct small molecule scaffolds that have been developed as antiviral agents against Venezuelan Equine Encephalitic ...
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Jennifer Golden, Xufeng Cao, Donghoon Chung, Colleen Jonsson, Michael Ryan, Xiaoyu Li, Jongwoo Son | P170217US02

Technology

Microorganisms And Methods For Producing Reuterin

UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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Jan Peter Van Pijkeren, Zhiying Wang | P230254US02

Technology

Turbinmicin Compounds, Compositions And Uses Thereof

The present invention from UW-Madison researchers is a small molecule antifungal agent isolated from a bacterial species found in the sea squirt Ecteinascidia turbinate. The inventors collected the sp...
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Timothy Bugni, Fan Zhang, Douglas Braun, David Andes, Miao Zhao | P180376US02

Technology

Derivatives Of Turbinmicin As Antifungal Agents

The present invention from UW-Madison researchers is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly i...
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Timothy Bugni, Weiping Tang, Le Guo, Changgui Zhao, Fan Zhang, Douglas Braun, David Andes, Miao Zhao, Jenna Fossen | P200353US02

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