The development of small-molecule compounds that target the murine double minute 2 protein (MDM2) represents a significant advancement in cancer therapy. MDM2 is known to inhibit the tumor suppressor ...
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UW Madison researchers and collaborators present a method of treating COVID-19 with lipid- peptide fusion antiviral therapy. Also described is a composition and method of treating Ebola with lipid-pep...
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The present invention from UW Madison researchers is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are part...
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The present invention from UW Madison inventors and collaborators is a set of two distinct small molecule scaffolds that have been developed as antiviral agents against Venezuelan Equine Encephalitic ...
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UW-Madison researchers along with collaborators engineered a multimodal nanocluster drug delivery particle for treating restenosis. The researchers formed the nanocluster by self-assembly of H40-polyl...
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UW-Madison researchers have developed a synthetic peptide through a single amino acid substitution and chemical conjugation of an aromatic molecule at the site of mutation that turns a peptide that bi...
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The present technology from UW-Madison researchers provides siderophore-polymer conjugates that enhance the sensitivity of bacteria to antibiotics, e.g., Pseudomonas, P. aeruginosa, Acinetobacter, and...
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UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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The present invention from UW-Madison researchers is a small molecule antifungal agent isolated from a bacterial species found in the sea squirt Ecteinascidia turbinate. The inventors collected the sp...
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UW-Madison researchers have discovered methods for alleviating the adverse effects of SSRIs in pregnancy through the co-administration of the known drug ketanserin. Using several in vivo experimental ...
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UW-Madison researchers have developed an improved delivery system that is able to penetrate the extracellular matrix (ECM) and shuttle surface-conjugated protein cages, composed of collagenases and an...
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UW-Madison researchers have developed ferritin-targeting proteolysis targeting chimeras (PROTACs) to establish an iron excess stress inside cancer cells. The PROTAC structure contains oleic acid for b...
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A UW-Madison researcher has discovered two cell surface biomarkers that can be used to distinguish older and newer MSCs in patient samples, which facilitates the separation of newer MSCs for therapeut...
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UW-Madison researchers have developed HeLa cell-adapted Rhinovirus-C (RV-C) variants that induce a strong cytopathic effect and replicate vigorously in HeLa-E8 cells. The inventors had previously show...
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UW-Madison researchers have developed a reporter cell line for identifying compounds that promote endothelial cell differentiation and nitric oxide production and identified four compounds that promot...
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UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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The present invention from UW-Madison researchers is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly i...
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UW-Madison researchers have discovered that inducing expression of the protein LRRC10 in mouse hearts promotes heart regeneration. Neonatal mice have hearts that naturally regenerate for the first wee...
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UW-Madison researchers have discovered a cell-surface marker (CD166) that can be used to distinguish (and purify) cells that are immature (early) cone photoreceptor precursor cells (CPPs), which will ...
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UW-Madison researchers have identified new mutations that promote replication of influenza A viruses to high titers in embryonated chicken eggs and would therefore increase the manufacturing yield for...
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UW-Madison researchers have developed a washed platelet extract with increased platelet growth factor concentration and decreased total protein relative to platelet rich plasma, and methods of making ...
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UW-Madison researchers have developed methods for making and using modified influenza gene products, alone or in combination, to inhibit WT virus replication, to serve as immunostimulatory agents, or ...
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UW researchers have created a biological therapeutic that stimulates the immune system to fight solid tumors. The researchers fused the cytokines IL-6 and IL- together to form a bifunctional biomol...
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The present invention from UW Madison researchers is a fusion protein made of the full length PDL-1 transmembrane protein and full length IDO cytosolic protein which the inventors termed PIDO. These t...
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UW-Madison researchers have developed a novel platform that can selectively and sustainably scavenge ROS in inflamed colon tissues while also improving probiotic delivery for gut microbiota homeostasi...
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