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267 Results for 'Therapeutics & Vaccines'
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Technology
MICROBIAL COMMUNITIES THAT PRODUCE BUTYRATE FROM FIBER AND METHODS OF USING SAME TO PRODUCE BUTYRATE
UW-Madison researchers have developed a method for increasing butyrate production in the gut. The method includes delivering a microbial community that include certain bacteria, yeasts, and other micr...
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Ophelia Venturelli, Erin Ostrem, Ryan Clark | P230206US02
Technology
SELECTION SYSTEMS, PEPTIDES DETERMINED THEREWITH, AND METHODS OF USING SAME
UW-Madison inventors have developed a new PACE-based platform for rapid discovery of bioactive cyclic peptide protein aggregation inhibitors. By linking cyclic peptide activity to phage reproduction, ...
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Tina Wang, Linwei Yang | P230455US02
Technology
Antimony Chelates For Targeted Auger Therapy And Imaging Diagnostics
UW-Madison researchers in collaboration with researchers at the Oak Ridge National Laboratory have developed chelated antimony (Sb) that can be used for targeted Auger radiotherapy. While 119Sb has be...
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Jonathan Engle, Aeli Olson, Nikki Thiele, Briana Schrage, Md Faizul Islam | P230454US02
Technology
Cyclic Peptide-Based Lysosome Targeting Degraders
UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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Weiping Tang, Yaxian Zhou, Yuan Zhao | P220339WO01
Technology
EXTRACELLULAR VESICLE THERAPY TO TREAT ORTHOPEDIC INJURY
UW-Madison researchers have developed methods for using mesenchymal stromal cell (MSC)-derived exosomes to promote ligament and tendon healing, including improvements to the mechanical properties of t...
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Peiman Hematti, Connie Chamberlain, John Kink, Ray Vanderby, Brian Walczak | P230034US02
Technology
Method To Make Small-Molecule Murine Double Minute 2 Protein (MDM2)-Degrading Compounds, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
The development of small-molecule compounds that target the murine double minute 2 protein (MDM2) represents a significant advancement in cancer therapy. MDM2 is known to inhibit the tumor suppressor ...
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Weiping Tang, Bo Wang, Suzhen Wu, Ka Yang | P190076US02
Technology
Lipid-Peptide Fusion Inhibitors As SARS-CoV-2 Antivirals
UW Madison researchers and collaborators present a method of treating COVID-19 with lipid- peptide fusion antiviral therapy. Also described is a composition and method of treating Ebola with lipid-pep...
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Samuel Gellman, Anne Moscona, Matteo Porotto, Victor Outlaw, Zhen Yu | P200290US02
Technology
Kir 7.1 Gene Therapy Vectors And Methods Of Using The Same
The present invention from UW Madison researchers is directed to improved AAV gene therapy constructs and pharmaceutical compositions for the expression of Kir7.1. The gene therapy constructs are part...
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Bikash Pattnaik, Pawan Shahi | P180340US05
Technology
Inhibitors Of Encephalitic Alphaviruses
The present invention from UW Madison inventors and collaborators is a set of two distinct small molecule scaffolds that have been developed as antiviral agents against Venezuelan Equine Encephalitic ...
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Jennifer Golden, Xufeng Cao, Donghoon Chung, Colleen Jonsson, Michael Ryan, Xiaoyu Li, Jongwoo Son | P170217US02
Technology
Biomimetic, Reactive Oxygen Species-Detonable Nanoclusters For Antirestenotic Therapy
UW-Madison researchers along with collaborators engineered a multimodal nanocluster drug delivery particle for treating restenosis. The researchers formed the nanocluster by self-assembly of H40-polyl...
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Shaoqin Gong, Yi Zhao, Kenneth Kent, Lianwang Guo, Bowen Wang, Takuro Shirasu | P210367US02
Technology
Activating Appendages To Induce Polypharmacology In Peptide Hormone Analogues, Including Dual GLP-1R / GIP Agonism
UW-Madison researchers have developed a synthetic peptide through a single amino acid substitution and chemical conjugation of an aromatic molecule at the site of mutation that turns a peptide that bi...
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Samuel Gellman, Kyle Brown, Rylie Morris | P230413US02
Technology
Siderophore-Polymer Conjugates For Increasing Bacterial Sensitivity To Antibiotics
The present technology from UW-Madison researchers provides siderophore-polymer conjugates that enhance the sensitivity of bacteria to antibiotics, e.g., Pseudomonas, P. aeruginosa, Acinetobacter, and...
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May Xiong, Max Purro | P160355US03
Technology
Microorganisms And Methods For Producing Reuterin
UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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Jan Peter Van Pijkeren, Zhiying Wang | P230254US02
Technology
Turbinmicin Compounds, Compositions And Uses Thereof
The present invention from UW-Madison researchers is a small molecule antifungal agent isolated from a bacterial species found in the sea squirt Ecteinascidia turbinate. The inventors collected the sp...
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Timothy Bugni, Fan Zhang, Douglas Braun, David Andes, Miao Zhao | P180376US02
Technology
METHOD FOR PREVENTING ADVERSE PREGNANCY OUTCOMES DUE TO USE OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI) DURING GESTATION
UW-Madison researchers have discovered methods for alleviating the adverse effects of SSRIs in pregnancy through the co-administration of the known drug ketanserin. Using several in vivo experimental ...
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Laura Hernandez, Rafael Reis Domingues, Milo Wiltbank | P230203US02
Technology
COMPOSITIONS AND METHODS TO ENHANCE IMMUNE CHECKPOINT BLOCKADE THERAPY AGAINST HYPOXIC TUMORS
UW-Madison researchers have developed an improved delivery system that is able to penetrate the extracellular matrix (ECM) and shuttle surface-conjugated protein cages, composed of collagenases and an...
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Quanyin Hu, Zhaoting Li | P230298WO01
Technology
FERRITIN-TARGETING PROTACS AND METHODS OF INDUCING PYROPTOSIS
UW-Madison researchers have developed ferritin-targeting proteolysis targeting chimeras (PROTACs) to establish an iron excess stress inside cancer cells. The PROTAC structure contains oleic acid for b...
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Quanyin Hu, Yu Chen | P230104WO01
Technology
REAGENTS AND METHODS FOR PREPARING ROBUST MESENCHYMAL STROMAL CELLS FOR THERAPY
A UW-Madison researcher has discovered two cell surface biomarkers that can be used to distinguish older and newer MSCs in patient samples, which facilitates the separation of newer MSCs for therapeut...
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Wan-Ju Li | P220259US02
Technology
HELA-ADAPTED RHINOVIRUSES C (RV-C) AND ADAPTIVE GENOMIC MUTATIONS
UW-Madison researchers have developed HeLa cell-adapted Rhinovirus-C (RV-C) variants that induce a strong cytopathic effect and replicate vigorously in HeLa-E8 cells. The inventors had previously show...
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James Gern, Yury Bochkov | P240269US01
Technology
REAGENTS AND METHODS FOR PROMOTING ARTERIAL ENDOTHELIUM DIFFERENTIATION AND NITRIC OXIDE PRODUCTION
UW-Madison researchers have developed a reporter cell line for identifying compounds that promote endothelial cell differentiation and nitric oxide production and identified four compounds that promot...
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James Thomson, Jue Zhang | P230071US02
Technology
VACCINE ADJUVANTS, TRANSFECTION REAGENTS, AND METHODS OF USING THE SAME
UW-Madison researchers have developed a new combination adjuvant composition (dubbed QTAP) that combines two safe adjuvants (Quil-A and DOTAP) using a nanoparticle preparation protocol developed by th...
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Adel Talaat, Bubacarr Touray | P220343US02
Technology
Derivatives Of Turbinmicin As Antifungal Agents
The present invention from UW-Madison researchers is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly i...
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Timothy Bugni, Weiping Tang, Le Guo, Changgui Zhao, Fan Zhang, Douglas Braun, David Andes, Miao Zhao, Jenna Fossen | P200353US02
Technology
METHODS OF INDUCING CARDIAC CELL PROLIFERATION AND INDUCING HEART REGENERATION
UW-Madison researchers have discovered that inducing expression of the protein LRRC10 in mouse hearts promotes heart regeneration. Neonatal mice have hearts that naturally regenerate for the first wee...
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Ahmed Mahmoud, Timothy Kamp, Youngsook Lee | P230238US02
Technology
IDENTIFICATION AND APPLICATION OF SELECTIVE CELL SURFACE MARKERS AND ADDITIONAL METHODS FOR HUMAN RED/GREEN CONE PHOTORECEPTOR PRECURSOR ENRICHMENT
UW-Madison researchers have discovered a cell-surface marker (CD166) that can be used to distinguish (and purify) cells that are immature (early) cone photoreceptor precursor cells (CPPs), which will ...
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David Gamm, Praveen Joseph Susai Manickam, Michael Phillips, Elizabeth Capowski | P220285US02
Technology
IMPROVED INFLUENZA VIRUS REPLICATION FOR VACCINE DEVELOPMENT
UW-Madison researchers have identified new mutations that promote replication of influenza A viruses to high titers in embryonated chicken eggs and would therefore increase the manufacturing yield for...
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Yoshihiro Kawaoka, Gabriele Neumann, Lizheng Guan | P230109US02