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62 Results for 'Drug Delivery'
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Technology
Reagents for Bioreversible Protein Esterification
Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Ronald Raines, Kalie Mix | P150262US03
Technology
Enhanced Drug Delivery Across the Blood-Brain Barrier: pH-Dependent Antibodies Targeting the Transferrin Receptor
Drug delivery to the brain is hampered by the presence of the blood-brain barrier (BBB), which excludes more than 98 percent of small molecule pharmaceuticals and nearly 100 percent of all protein and...
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Eric Shusta, Benjamin Tillotson | P150370US02
Technology
Phage-Cured Lactobacillus Strains for Therapeutic Delivery
In addition to key roles in food and biofuel production, probiotic strains of lactic acid bacteria are being exploited in medicine as therapeutic delivery vehicles. One obstacle is that bacteriophages...
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Jan Peter Van Pijkeren, Jeehwan Oh | P170020US01
Technology
Bioreversible Boronates Improve Drug Delivery
The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Ronald Raines, Thomas Smith | P150009US02
Technology
Enhancing Cell Penetration to Improve Drug Delivery
The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Ronald Raines, Kristen Andersen | P150031US02
Technology
Lipid-Free Emulsions for Delivering Anesthesia, Other Hydrophobic Drugs
Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Sandro Mecozzi, Robert Pearce | P140235US02
Technology
Lipid-Free, Stabilized Emulsions for Delivering Anesthesia and Other Hydrophobic Drugs
Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Sandro Mecozzi, Robert Pearce, William Tucker | P140337US02
Technology
New Target for Diagnosing, Treating Neurodegenerative Diseases
Amyotrophic lateral sclerosis (ALS) is a devastating disease with no effective treatment. In patients with ALS, the neurons in their brains degenerate, leading to cognitive and physical breakdown. Oth...
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Su-Chun Zhang, Hong Chen | P140125US02
Technology
Blood-Brain Barrier Targeting Antibodies to Improve Drug Delivery
Even though therapeutic compounds have been developed for neurologic disorders such as Alzheimer’s disease, these conditions remain difficult to treat in large part because of the blood-brain barrie...
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Eric Shusta, Angela Jones, Charles Stutz | P140126US02
Technology
Gene Editing Tool Uses New Enzyme
Genome editing has proven difficult in cells, especially mammalian cells. One way to improve efficiency is to introduce a double-strand break (DSB) in the desired DNA region. These DSBs stimulate cell...
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James Thomson, Zhonggang Hou, Yan Zhang, Rakhi Rajan, Erik Sontheimer, Alfonso Mondragón | P130315US02
Technology
Treating Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is a disorder driven by overproliferating leukemia cells in bone marrow and blood. Targeted therapy uses thyrosine kinase inhibitors to inhibit leukemia cells, but fails...
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Igor Slukvin, Kran Suknuntha | P130277US02
Technology
Thermogel for Combination Drug Delivery
As cancer research progresses, it is evident that single drug formulations only provide limited success. Developing combination therapies would greatly benefit patients, especially those who must fol...
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Glen Kwon, Hyunah Cho | P130338US03
Technology
Improving Drug Delivery with Boronic Acids
The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Ronald Raines, Gregory Ellis, Michael Palte | P110315US02
Technology
Multilayered Films for the Controlled Release of Anionic Molecules, Including Nucleic Acids
The ability to control the delivery of biomolecules to cells and tissues has many therapeutic and research applications. In particular, spatial and temporal control over the release of multiple biolog...
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David Lynn, Jingtao Zhang, Xianghui Liu | P08128US02
Technology
Biocompatible Formulations of Poorly Soluble Anticancer Drugs Such as Gossypol
Many powerful drugs have only limited usefulness because they are relatively insoluble in aqueous solutions. For example, gossypol has been identified as an effective inhibitor of Bcl-2 proteins, whic...
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Glen Kwon, Ho-Chul Shin, Hyunah Cho | P100278US02
Technology
Microfluidic Device for Drug Delivery
Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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David Beebe, Michael MacDonald, David Eddington, Glennys Mensing | P04240US
Technology
Charge-Dynamic Polymers for Delivering Anionic Compounds, Such as DNA, into Cells
The safe and efficient delivery of DNA into cells is essential for the clinical success of gene therapy. Synthetic polymers are considered long-term alternatives to virus-based gene delivery agents be...
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David Lynn, Adam Miller | P03393US
Technology
Layer-by-Layer Covalent Assembly of Reactive Ultrathin Films
Methods that allow reactive polymer films to be deposited or assembled on topologically complex substrates are useful for the patterning or chemical modification of surfaces in a broad range of applic...
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David Lynn, Maren Buck, Jingtao Zhang | P08130US
Technology
Novel Charge Shifting Anionic Polymers for the Controlled Release of Cationic Agents from Surfaces
The ability to deliver biomolecules, such as proteins or nucleic acids, into cells has many therapeutic and research applications. Polyelectrolyte multilayers (PEMs) have been used to deliver biomolec...
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David Lynn, Xianghui Liu, Jingtao Zhang | P08389US
Technology
Multilayered Film for Delivering Proteins and Other Small Molecules into Cells
The ability to deliver proteins into cells has many therapeutic and research applications. However, peptide drugs and therapeutic proteins are notoriously difficult to administer, in part because of t...
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David Lynn, Ronald Raines, Christopher Jewell, Stephen Fuchs, Ryan Flessner | P07251US
Technology
Method for Generating Primate Trophoblasts
Embryonic stem cells are undifferentiated cells that can differentiate into a number of progenitor cell types. A trophoblast is a differentiated cell that is a precursor of the cells which participate...
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James Thomson, Ren-He Xu | W03002US
Technology
Endothelial Cells Derived from Human Embryonic Stem Cells
Although techniques exist for differentiating human embryonic stem cells (ES cells) into a number of specific cell types, no method currently exists for directing ES cell cultures to become endothelia...
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Dan Kaufman, Rachel Lewis, Robert Auerbach | P02004US
Technology
High Titer Recombinant Influenza Viruses for Vaccines and Gene Therapy
Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, the conventional influenza vaccine must be adapted almost every year,...
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Yoshihiro Kawaoka | P03322US
Technology
Method of Forming Mesenchymal Stem Cells from Embryonic Stem Cells
Mesenchymal stem cells (MSCs) are precursors to mesenchymal tissues, such as bone, dental tissue, cartilage, tendon, bone marrow stroma, hematopoietic lineages, and muscle. Bone marrow is a useful sou...
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John Wesley Pike, Nirupama Pike | P04247US
Technology
Coatings That Inhibit Crystallization of Amorphous Drugs to Improve Stability
Many drugs that are potentially efficacious for treating diseases, such as cancer, have limited usefulness because they are relatively insoluble. Preparing these drugs in an amorphous, or “glass...
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Lian Yu, Melgardt De Villiers, Tian Wu | P07314US