Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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Drug delivery to the brain is hampered by the presence of the blood-brain barrier (BBB), which excludes more than 98 percent of small molecule pharmaceuticals and nearly 100 percent of all protein and...
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In addition to key roles in food and biofuel production, probiotic strains of lactic acid bacteria are being exploited in medicine as therapeutic delivery vehicles. One obstacle is that bacteriophages...
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The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Emulsions containing soybean oil have been used intravenously for more than 40 years. Recently they have been employed in the delivery of certain hydrophobic drugs such as anti-inflammatory agents and...
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Amyotrophic lateral sclerosis (ALS) is a devastating disease with no effective treatment. In patients with ALS, the neurons in their brains degenerate, leading to cognitive and physical breakdown. Oth...
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Even though therapeutic compounds have been developed for neurologic disorders such as Alzheimer’s disease, these conditions remain difficult to treat in large part because of the blood-brain barrie...
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Genome editing has proven difficult in cells, especially mammalian cells. One way to improve efficiency is to introduce a double-strand break (DSB) in the desired DNA region. These DSBs stimulate cell...
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Chronic myeloid leukemia (CML) is a disorder driven by overproliferating leukemia cells in bone marrow and blood. Targeted therapy uses thyrosine kinase inhibitors to inhibit leukemia cells, but fails...
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As cancer research progresses, it is evident that single drug formulations only provide limited success. Developing combination therapies would greatly benefit patients, especially those who must fol...
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The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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The ability to control the delivery of biomolecules to cells and tissues has many therapeutic and research applications. In particular, spatial and temporal control over the release of multiple biolog...
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Many powerful drugs have only limited usefulness because they are relatively insoluble in aqueous solutions. For example, gossypol has been identified as an effective inhibitor of Bcl-2 proteins, whic...
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Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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The safe and efficient delivery of DNA into cells is essential for the clinical success of gene therapy. Synthetic polymers are considered long-term alternatives to virus-based gene delivery agents be...
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Methods that allow reactive polymer films to be deposited or assembled on topologically complex substrates are useful for the patterning or chemical modification of surfaces in a broad range of applic...
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The ability to deliver biomolecules, such as proteins or nucleic acids, into cells has many therapeutic and research applications. Polyelectrolyte multilayers (PEMs) have been used to deliver biomolec...
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The ability to deliver proteins into cells has many therapeutic and research applications. However, peptide drugs and therapeutic proteins are notoriously difficult to administer, in part because of t...
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Embryonic stem cells are undifferentiated cells that can differentiate into a number of progenitor cell types. A trophoblast is a differentiated cell that is a precursor of the cells which participate...
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Although techniques exist for differentiating human embryonic stem cells (ES cells) into a number of specific cell types, no method currently exists for directing ES cell cultures to become endothelia...
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Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, the conventional influenza vaccine must be adapted almost every year,...
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Mesenchymal stem cells (MSCs) are precursors to mesenchymal tissues, such as bone, dental tissue, cartilage, tendon, bone marrow stroma, hematopoietic lineages, and muscle. Bone marrow is a useful sou...
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Many drugs that are potentially efficacious for treating diseases, such as cancer, have limited usefulness because they are relatively insoluble. Preparing these drugs in an amorphous, or “glass...
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