Wisconsin Alumni Research Foundation

Technology

Microfluidic Device for Drug Delivery

Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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David Beebe, Michael MacDonald, David Eddington, Glennys Mensing | P04240US

Technology

Method for Generating Primate Trophoblasts

Embryonic stem cells are undifferentiated cells that can differentiate into a number of progenitor cell types. A trophoblast is a differentiated cell that is a precursor of the cells which participate...
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James Thomson, Ren-He Xu | W03002US

Technology

Spatial Control of Signal Transduction

Development of most tissue types involves a complex interplay of multiple growth factors in well defined locations, leading to controlled differentiation of precursor cells into mature, tissue-specifi...
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William Murphy, Gregory Hudalla | P05255US

Technology

Method of Forming Dendritic Cells from Embryonic Stem Cells

Dendritic cells are used as a base for vaccines and in the study of antigen processing within the human body. However, obtaining large quantities of the cells, which are generated in bone marrow, is l...
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Igor Slukvin, James Thomson, Maksym Vodyanyk, Maryna Gumenyuk | P04434US

Technology

Multilayer Tissue Regeneration System

Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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William Murphy | P05256US

Technology

Nanoparticles That Target Dendritic Cells

Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US

Technology

Blood-Brain Barrier Targeting Antibodies

Even though therapeutic compounds have been developed for neurologic disorders, such as Alzheimer’s disease, these conditions remain difficult to treat, largely because of the blood-brain barrie...
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Eric Shusta, Xin Wang, Yongku Cho | P06056US

WARF