Wisconsin Alumni Research Foundation

Technology

CHO Cell Line Expressing HERG-1 Potassium Channels

HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US

Technology

Methods Of Inhibiting Metastasis In Cancer

As described herein, a method of inhibiting metastasis in cancer includes administering to a human subject diagnosed with a cancer of an organ of the peritoneal cavity a therapeutically effective amou...
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Pamela Kreeger, Molly Carroll, Kaitlin Fogg | P180025US02

Technology

Methods Of Controlling Red Blood Cell Production

A method of controlling red blood cell production includes contacting red blood cell precursors with a composition including zinc, a composition including an inhibitor of a zinc exporter protein, or a...
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Emery Bresnick, Nobuyuki Tanimura | P180160US02

Technology

Increasing Red Blood Cell Production

Maintaining an adequate supply of oxygen to tissue is necessary for survival. The oxygen-carrying capacity of blood is governed by the concentration of red blood cells (erythrocytes). It is critical t...
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Emery Bresnick, Yoon A Kang, Skye McIver | P130326US02

Technology

Common Variants of the Sodium Channel Alpha Subunits

The SCN5A gene encodes a human cardiac sodium (Na+) channel alpha subunit that carries the inward Na+ current in the heart. Three distinct polymorphic SCN5A clones, hH1, hH1a and hH1b, have been isola...
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Jonathan Makielski, Bin Ye, Michael Ackerman | P02284US

Technology

Protein Inhibitor of Ran Activity

Proteins and nucleic acids are actively transported in and out of the nucleus through nuclear pores. A small protein called Ran is the gatekeeper for large, complex pore structures.
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Ann Palmenberg, Frederick Porter, Christiane Wiese, Yury Bochkov | P06152US

Technology

Method to Screen for Novel Antibiotics

The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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Bernard Weisblum, Robert Giannattasio, Arcady Grenader, Andrew Ulijasz, David Kovalic | P96061US

Technology

Stem Cell Marker for Breast Cancer

In patients who develop breast cancer, malignant tumors frequently begin in somatic mammary stem cells. In addition, breast tumors have a stem cell component that propagates the tumor, which may expla...
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Caroline Alexander, Bart Williams, Charlotta Lindvall, Nisha Badders | P07136US

Technology

Receptor For Bacillus anthracis Toxin

Infection with Bacillus anthracis, the spore-forming causative agent of anthrax, can result in either a generally benign, self-limiting cutaneous disease or a more serious and often fatal systemic dis...
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John Young, Kenneth Bradley, R. John Collier, Jeremy Mogridge | P00305US

Technology

Vaccine Candidates Against Johne's Disease

Johne’s disease is a contagious, chronic and usually fatal wasting disease that primarily affects the small intestine of ruminants. It is a worldwide problem with no known treatment and infects ...
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Adel Talaat | P05446US

WARF