WARF TECHNOLOGIES

UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researchers generated RgnTDC mutants via heterologous expression, enabling efficient production of these mutants for use as biocatalysts at scale. Finally, the researchers established the utility of these mutations in multiple formats including, whole-cell, single-enzyme, and multi-enzyme cascades.

For More Information About the Inventors

• Andrew Buller

Tech Fields

• Drug Discovery & Development : Other drug discovery & development
• Research Tools : Biomanufacturing