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8 Results for 'Other therapeutic technologies'
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Technology
Senolytic CRISPR CAR T Cells Produced By CRISPR-Cas9 Genome Editing
UW Madison researchers have developed a virus-free, CRISPR-Cas mediated method of generating T cells that target senescent cells. These modified T cells could be used to treat Alzheimer’s Disease an...
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Krishanu Saha, Lauren Sarko | P220135US02
Technology
MUTANT ACE2 PROTEINS AND METHODS OF USING SAME
UW-Madison researchers have identified novel ACE2 mutants having enhanced activity and/or specificity in hydrolyzing angiotensin II. ACE2 (angiotensin converting enzyme 2) is a key metalloprotease of ...
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Philip Romero, Peter Heinzelman | P210188WO01
Technology
Anti-CD40 Single-Chain Variable Fragment And Human IL-21 Fusion Protein (CD40SCFV-IL-21)
UW-Madison researchers have developed a novel fusion protein for inducing Breg cell formation and a method for transforming any human B cell into an IL10-competent, functional Breg cell ex vivo at sca...
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Jacques Galipeau, Andrea Pennati, Shala Yuan | P210323WO01
Technology
COMPOSITIONS AND METHODS FOR PREVENTION OF BLADDER FIBROSIS
A composition for the treatment of bladder fibrosis in a patient in need that includes a miR-29 mimic is disclosed. The miR-29 mimic may include a working RNA strand with the nucleotide sequence UAGCA...
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Dale Bjorling, Jianghui Hou, Zunyi Wang | P200076US02
Technology
REGULATORY ELEMENTS FOR SCHWANN CELL-SPECIFIC GENE EXPRESSION
Regulatory elements that drive Schwann cell-specific gene expression, nucleic acid vectors, virus particles, and therapeutic compositions incorporating these constructs; and methods of using these var...
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John Svaren | P200262WO01
Technology
Compounds and Methods for Modulating Frataxin Expression in Friedreich’s Ataxia
Friedreich’s Ataxia (FRDA) is a neurodegenerative disorder without treatments to halt or reverse disease progression, affecting roughly 9,000 Americans. FRDA is caused by triplet expansion in the fi...
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Aseem Ansari, Graham Erwin, Matthew Grieshop | P160232US07
Technology
Gene Correction of Pompe Disease and Other Autosomal Recessive Disorders via CRISPR and other RNA-Guided Nucleases
Pompe disease is a rare autosomal recessive genetic disease (mutations from both parent carriers have to be inherited by the offspring to see symptoms) that typically affects children during developme...
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Krishanu Saha, Jared Carlson-Stevermer, Lucille Kohlenberg | P190021US02
Technology
Compounds And Methods For Modulating Frataxin Expression
Friedreich’s ataxia (also referred to as FA or FRDA) is a rare but fatal autosomal recessive neurodegenerative disease. With an estimated incidence of 1 in every 40,000 people, it causes progressive...
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Aseem Ansari, Graham Erwin, Matthew Grieshop | P160232US05