Wisconsin Alumni Research Foundation

Technology

Novel Methods for In Vivo Cell Tracking

Cell therapy is a novel and promising approach to treating diseases such as rheumatoid arthritis, atherosclerosis, acute ischemia, myocardial infarction, diabetes, graft versus host disease and cancer...
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Reinier Hernandez, Anatoly Pinchuk, Liudmila Lambert Lepesevich, Zachary Rosenkrans, Anna Thickens, Nathan Clemons | P230038US01

Technology

HUMAN BLOOD-BRAIN BARRIER MODEL FOR IMMUNOLOGICAL STUDIES

A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
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Eric Shusta, Hideaki Nishihara, Benjamin Gastfriend, Sean Palecek, Britta Engelhardt | P200363US03

Technology

Method Of Manufacturing Micelles For Drug Delivery

UW Madison researchers have developed a novel way to manufacture large amount of micellular paclitaxel. Rather than using organic solvents to get the paclitaxel solubilized and loaded into micelles, t...
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Glen Kwon, Morteza Rasoulianboroujeni, Rae Hyung Kang | P220070US02

Technology

UW-Madison researchers have developed a highly efficient biocatalytic route for production of diverse γ-hydroxy amino acids starting from L-aspartate and readily available aldehydes. The method ...
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Andrew Buller, Jonathan Ellis, Prasanth Kumar | P190336US02

Technology

MUTANT ACE2 PROTEINS AND METHODS OF USING SAME

UW-Madison researchers have identified novel ACE2 mutants having enhanced activity and/or specificity in hydrolyzing angiotensin II. ACE2 (angiotensin converting enzyme 2) is a key metalloprotease of ...
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Philip Romero, Peter Heinzelman | P210188WO01

Technology

VACO6

A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
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James Willson | P230180US01

Technology

UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with a...
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Wei Guo, Yanghai Zhang | P230097US01

Technology

Primatized Mouse

The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
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Matthew Brown | P210237US02

Technology

Knockout of GFAP In the Mouse (Model tm1Mes)

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01

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