Wisconsin Alumni Research Foundation

Animals, Agriculture & Food
Animals Agriculture Food
Preen Oil: The Nutritional Approach to Chronic Inflammation
WARF: P160017US01

Inventors: Mark Cook, Jordan Sand, Jake Olson, Terence Barry

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing new methods and food additives based on preen oil to reduce chronic inflammation.
Low-grade chronic inflammation underpins many diseases affecting both human and animal health. It remains largely undiagnosed and undertreated worldwide.

Preen oil, secreted by the uropygial gland of many bird species, is a readily available product commonly discarded in the meat processing industry. Preen oil contains fatty acids such as nonadecanoic acid (NA), which have anti-inflammatory activity.
The Invention
UW–Madison researchers have developed methods of using preen oil as a food supplement to treat chronic inflammation in human and non-human animals, birds and fish.

Preen oil may be given orally as a pharmaceutical composition, added to human food products or included in animal, bird or fish food. The fatty acids in the oil accumulate in tissues where they inhibit the pro-inflammatory cytokines IL-1 and IL-6 and reduce chronic inflammation, including chronic joint inflammation associated with rheumatoid arthritis and other diseases.
  • Animal feed supplements
  • Human food additive
  • Fish growth stimulation in aquaculture
  • Oral treatment for chronic inflammation in the digestive tract and arthritis
Key Benefits
  • Reduces pro-inflammatory IL-1 and IL-6 associated with inflammation and joint destruction
  • Decreases incidences of gastrointestinal inflammation, enhancing feed/nutritional efficiency in commercial animals
  • Stimulates growth in larval and growing fish species
  • Allows for use of inexpensive fish feed while shortening growth cycles
  • Uses a natural and available substance that would otherwise be discarded, adding a new revenue stream from meat processing
  • Low-cost development
  • Preen oil is safe for consumption.
Stage of Development
The inventors have demonstrated lowered proinflammatory cytokine levels and increased growth rate without fat deposition in arthritic sham mice and increased larval growth in fathead minnows.

The development of this technology was supported by WARF Accelerator. WARF Accelerator selects WARF's most commercially promising technologies and provides expert assistance and funding to enable achievement of commercially significant milestones. WARF believes that these technologies are especially attractive opportunities for licensing.
Additional Information
Related Intellectual Property
For current licensing status, please contact Emily Bauer at [javascript protected email address] or 608-960-9842