Drug Delivery
Osmotic Enhancement Of Drug/Therapeutic Delivery To The Brain Following Infusion Or Injection Into The Cerebrospinal Fluid
WARF: P160077US02
Inventors: Robert Thorne, Daniel Wolak, Michelle Pizzo
The Invention
A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patient's cerebrospinal fluid (CSF), wherein the osmolyte is introduced to the CSF at a concentration of between 0.5 and 12.9 M (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte.
Tech Fields
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857