Wisconsin Alumni Research Foundation

Drug Delivery
Drug Delivery
WARF: P200063US02

Inventors: Eric Shusta, Charles Stutz, Loukas Goulatis, Julia Georgieva

The Invention
UW-Madison researchers have identified new antibodies and related single-chain antibody fragments (scFvs) that bind and transport across the brain vasculature. These promising antibodies were discovered using in vivo phage screening methods in combination with the inventors’ previously disclosed iPSC-derived BBB models. The scFvs selectively bind to brain endothelial cell membranes and can be conjugated to an active payload (e.g., drug, antisense oligonucleotide, etc.). Upon binding, the scFv and its conjugated payload is endocytosed into the endothelial cell. As a result, these scFvs could enable highly-selective, noninvasive drug delivery to the brain and central nervous system (CNS).  
Additional Information
For More Information About the Inventors
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854