Wisconsin Alumni Research Foundation

Clean Technology
Clean Technology
Cells And Methods For Producing Methyl Ketones
WARF: P200352WO01

Inventors: Brian Pfleger, Nestor Hernandez Lozada, Qiang Yan, Trevor Simmons

The Invention
Recombinant cells and methods for producing methyl ketones, such as medium-chain methyl ketones. The recombinant cells include recombinant acyl-ACP thioesterase genes, recombinant β-ketoacyl-CoA thioesterase genes, and recombinant acyl-CoA synthetase genes, in addition to other modifications. The methods include culturing the recombinant cells to produce the methyl ketones and isolating the produced methyl ketones.
  • Modified microorganisms that produce higher titer medium-chain methyl ketones
  • Medium-chain methyl ketones have current uses as chemical intermediates, flavors, and fragrances, and their compatibility with diesel fuels shows their potential as liquid fuels
Key Benefits
  • High titer production from E. coli
  • Potential as biorenewable liquid fuel
  • Production of medium-chain methyl ketones which can be condensed to long-chain fuels
  • Production likely further applicable to other medium-chain oleochemicals
Additional Information
For More Information About the Inventors
For current licensing status, please contact Jennifer Gottwald at [javascript protected email address] or 608-960-9854