Drug Delivery
Methods And Compositions for the Treatment of Cancer
WARF: P240259US02
Inventors: John-Demian Sauer, Paul Sondel, Alexander Rakhmilevich, Kijeong Lee, Zachary Morrow
The Invention
UW-Madison researchers have developed a formulation of biologically active immunostimulatory proteins that are delivered specifically into the tumor microenvironment. The researchers use a non-pathogenic Listeria strain as the delivery vehicle. This strain of bacteria collects in the tumor microenvironment. The researchers modified the strain to prevent it from entering cells and transfected the bacteria with an expression vector for interleukin 2 (IL-2). The bacteria secrete full length, bioactive IL-2 into the tumor microenvironment. That stimulates immune cells to infiltrate the tumor and destroy tumor cells.
Additional Information
For More Information About the Inventors
Tech Fields
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857