Mycobacterial infections cause major health problems for people and animals, including human tuberculosis, bovine tuberculosis and Johne’s disease. Johne’s disease (or paratuberculosis) afflicts 9...
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Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Detection of genetic aberrations using nucleic acids as biomarkers can be a powerful strategy for disease diagnosis and progression monitoring; however, the high heterogeneity of cells within a patien...
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A UW-Madison researcher has developed a method for identifying cancer patients who will respond well to radiation treatment by measuring the chromosomal instability levels of the tumor cells. The rese...
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UW-Madison researchers in collaboration with University of Kansas researchers have developed a blood-based assay capable of quantifying MUC16/CA125 levels in serum. This assay does not use antibodies,...
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UW-Madison researchers have developed a tagged primer system for identifying nucleic acid contamination in genetic sequencing experiments that involve serial PCR amplification steps. The system relies...
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UW-Madison researchers have generated a new human GATA2 deficiency model. The model was generated using CRISPR-Cas9 targeting to deactivate one copy of the GATA2 gene in HUDEP-2 cells. This cell line,...
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UW-Madison researchers developed a method of quantifying genetic breakpoints in circulating tumor DNA that is relatively simple and can be completed in less than a day. This method can be used to moni...
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UW-Madison researchers have identified a panel of metabolites that could be useful indicators of AKI. A prospective observational study of NICU patients was completed, including the collection of urin...
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UW-Madison researchers have developed a novel camelid antibody against the cancer target cMET. As cMET is overexpressed on many tumors, this antibody may be useful for imaging tumors and/or delivering...
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UW-Madison researchers have developed a method of enriching microbial DNA in a plasma DNA sample for early detection of microbial infection. Previously, this group found that microbial DNA fragments a...
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UW-Madison researchers have developed monoclonal antibodies to ketamine and monoclonal antibodies to 6-HNK, one of the major metabolites of ketamine. The antibodies are selective enough to bind to the...
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UW-Madison researchers have developed a method of diagnosing cancer through detection of specific fragmentation patterns of cell free DNA in plasma. Their approach is distinctly focused on positioning...
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UW-Madison researchers have discovered that the midbody (MB) functions as an RNA-based organelle with active translation activity, which serves as a novel means of RNA-based intercellular communicatio...
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UW-Madison researchers have developed a method of identifying and characterizing DNA fragmentation patterns in circulating tumor cells using targeted circulating tumor cell DNA (ctDNA) panels. These r...
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A UW researcher has developed a higher throughput method for detection of the methylation pattern of the alleles involved in Prader-Willi and Angelman disorders from dried blood spots. This method pro...
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A UW-Madison researcher has developed a new diagnostic assay for Sjogren's syndrome, based on her discovery of novel autoantibodies relevant to the disease process. Using whole peptidome array tec...
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UW-Madison researchers have developed a genetic rescue assay that discriminates the activities of wild type DDX41 from those of human myeloid malignancy-associated germline and somatic DDX41 mutants. ...
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Rheumatoid factors (RFs) are antibodies that commonly develop in patients with rheumatoid arthritis (RA), an incurable autoimmune disease that affects ~1% of the population. RFs bind to IgG and other ...
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UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method consists of ...
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Staff at the Wisconsin State Laboratory of Hygiene have prepared influenza virus isolate A/Wisconsin/588/2019 (FR-1758), as part of their influenza surveillance work through the national CDC-led influ...
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UW-Madison researchers have identified and validated a set of human T cell specific biomarkers that can predicti graft-vs-host disease (GVHD) and/or relapse following allogeneic hematopoietic stem cel...
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UW-Madison researchers have developed mass spectrometry (MS) compatible nanoparticles for the selective capture and enrichment of low abundance proteins. The surface of superparamagnetic nanoparticles...
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Using two sets of comparative patient samples (hospitalized COVID-19 patients vs controls from 3 years ago, and hospitalized COVID-19 patients vs patients hospitalized for other conditions), the inven...
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UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.   
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