UW Madison researchers have developed a novel way to manufacture large amount of micellular paclitaxel. Rather than using organic solvents to get the paclitaxel solubilized and loaded into micelles, t...
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UW-Madison researchers have developed a highly efficient biocatalytic route for production of diverse γ-hydroxy amino acids starting from L-aspartate and readily available aldehydes. The method ...
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UW-Madison researchers have developed a protein-based method for selective deuteration of amino acids. The inventors’ method leverages the aminotransferase DsaD, a PLP-dependent enzyme, and a sm...
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UW-Madison researchers have identified novel ACE2 mutants having enhanced activity and/or specificity in hydrolyzing angiotensin II. ACE2 (angiotensin converting enzyme 2) is a key metalloprotease of ...
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The UW researcher identified IgG sequences that bind Rheumatoid Factors (RFs) involved in rheumatoid arthritis (RA) and/or COVID-19. These peptides could be used as diagnostic reagents to monitor the ...
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A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
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Building off of their prior discovery (Photo-Cleavable Surfactants P180335US02), UW-Madison researchers disclose an improved method for exosome proteomics. The method leverages the researchers’ ...
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UW-Madison researchers have developed methods for bioprinting a human neural network in vitro. The inventors’ method fabricates human neural tissues that form a functional neural network within ...
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UW researchers have developed a novel means of degrading extracellular proteins as a potential cancer treatment. The researchers recognized that transferrin is a protein ligand that carries iron into ...
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UW-Madison researchers have developed a titin DNA construct (a ‘titin minigene plasmid’) that is useful for identifying agents that modulate the titin size reduction that correlates with a...
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UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previous...
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The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
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UW researchers have developed modified genetically encoded plasma membrane voltage probes for monitoring mitochondrial and ER membrane voltage gradients. A fluorescence protein tag was coupled with a ...
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UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
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UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
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UW-Madison researchers have developed a mouse model of Alexander disease, designated B6.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is ...
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UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is...
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UW-Madison researchers have developed a transgenic mouse, designated Tg73.7, that carries full-length copies of a human genomic clone of wild-type GFAP, including all introns and exons.
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UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm3Mes, that was engineered as a knock-in of the R76H point mutation in the Gfap gene. This is ...
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Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
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Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
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Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
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Viruses maximize their genetic potential through several mechanisms including expressing multiple protein products from a single mRNA template. A crucial mechanism is conserved by both retroviruses, i...
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