Wisconsin Alumni Research Foundation

Technology

Rat Model of Alexander Disease

Alexander disease (AxD) is a rare disease of the central nervous system characterized by formation of protein aggregates within astrocytes and disruption of growth or maintenance of the myelin sheath....
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Albee Messing, Tracy Hagemann | P170228US01

Technology

Blood-Brain Barrier Model

Accurately reproducing the blood-brain barrier in an in vitro setting has been a longstanding challenge. Current methods require the independent isolation of multiple cell types, and the quality of th...
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Eric Shusta, Clive Svendsen, Christian Weidenfeller | P06318US02

Technology

Research Tool for Protein Conformation Analysis

The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, Juda Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02

Technology

Animal Model of Brittle Bone Disease

Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
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Daniel Greenspan, Se-Jin Lee | P160036US01

WARF