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129 Results for 'Drug Discovery & Development'
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Technology
Knockout of GFAP In the Mouse (Model tm1Mes)
UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01
Technology
SARS-COV-2 OMICRON BA.2 VARIANT FOR MEDICAL COUNTERMEASURE EVALUATION
UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
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Yoshihiro Kawaoka | P220198US01
Technology
SARS-COV-2 BA.1 OMICRON VARIANT FOR MEDICAL COUNTERMEASURE EVALUATION
UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
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Yoshihiro Kawaoka, Peter Halfmann | P220159US01
Technology
Mouse Model of Alexander Disease (Model B6.129S7 (Cg) Gfap tm2Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated B6.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is ...
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Albee Messing, Tracy Hagemann | P220167US01
Technology
Mouse Model of Alexander Disease (Model FVB.129S7 (Cg) Gfap tm2Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm2Mes, that was engineered as a knock-in of the R236H point mutation in the Gfap gene; this is...
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Albee Messing, Tracy Hagemann | P220165US01
Technology
Transgenic Mouse Expressing Human GFAP (Model Tg73.7)
UW-Madison researchers have developed a transgenic mouse, designated Tg73.7, that carries full-length copies of a human genomic clone of wild-type GFAP, including all introns and exons.
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Albee Messing, Michael Brenner | P220166US01
Technology
Mouse Model of Alexander Disease (Model FVB.129S7 (Cg) Gfap tm3Mes)
UW-Madison researchers have developed a mouse model of Alexander disease, designated FVB.129S7 (Cg) Gfap tm3Mes, that was engineered as a knock-in of the R76H point mutation in the Gfap gene. This is ...
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Albee Messing, Tracy Hagemann | P220169US01
Technology
CHEMICAL COCKTAIL FOR INDUCING SENESCENCE IN HUMAN NEURONS TO PROMOTE DISEASE MODELING AND DRUG DISCOVERY
Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
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Su-Chun Zhang, Ali Fathi | P200006US02
Technology
METHODS FOR CONTROLLED INDUCTION OF BIOENGINEERED NEUROEPITHELIAL TISSUES AND 3-D NEUROEPITHELIAL TUBES
Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
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Randolph Ashton, Gavin Knight, Benjamin Knudsen, Nisha Iyer, Carlos Marti-Figueroa | P200307US03
Technology
GENERATION OF NOREPINEPHRINE NEURONS FROM HUMAN STEM CELLS
Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
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Su-Chun Zhang, Yunlong Tao | P200364US02
Technology
Mouse Models for Protein Granule Diseases
Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
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Wei Guo | P210193US01
Technology
Cell-Based Assay for Identifying Inhibitors of Viral Translational Recoding
Viruses maximize their genetic potential through several mechanisms including expressing multiple protein products from a single mRNA template. A crucial mechanism is conserved by both retroviruses, i...
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Nathan Sherer, Bayleigh Benner | P200340US01
Technology
PLASMID ENCODING INFECTIOUS RHINOVIRUS-C GENOTYPE C45
UW-Madison researchers have cloned, sequenced and characterized the genome from an isolate of the RV-C45 genotype, and they’ve provided the cDNA for a high titer HRV-C (C45-2A-D41K), as well as ...
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Ann Palmenberg | P210398US01
Technology
RPE CELL LINES WITH PLK4 CONDITIONAL KNOCKOUT AND ANALOG SENSITIVE MUTATION
UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta&rdq...
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Mark Burkard, Ryan Denu | P210364US01
Technology
CHO Cell Line Expressing HERG-1 Potassium Channels
HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US
Technology
Plasmids And Cell Lines Expressing The DMPK 3'UTR
The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
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Mani Mahadevan, Jeffrey Amack | P210221US01
Technology
Fluorescent-Tagged Moraxella Catarrhalis For Cell Culture Experiments
The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
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Cameron Currie, Reed Stubbendieck | P210244US01
Technology
Method Of In Vitro Differentiation Of Neural Stem Cells, Motor Neurons And Dopamine Neurons From Pri
A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of ...
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Su-Chun Zhang, Xue-jun Li | P07445US
Technology
Neoglycorandomization And Digitoxin Analogs
The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred...
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Joseph Langenhan | P08057US
Technology
Enhanced Neoglycosides Through Neoglycosylation And Methods Of Use Thereof
Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library ...
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Jon Thorson, Randal Goff | P07498US02
Technology
Engineered Glycosyltransferases With Expanded Substrate Specificity
The present invention provides engineered glycosyltransferase enzymes and method for making and using the same possessing an expanded substrate specificity as compared to corresponding non-mutated gly...
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Jon Thorson, Gavin Williams, Richard Gantt | P07447US
Technology
Topical Vasoconstrictor Preparations And Methods For Protecting Cells During Cancer Chemotherapy And
Vasoconstrictors are administered topically to provide protection against the adverse effects, e.g., alopecia, mucositis or dermatitis, induced by chemotherapy or radiotherapy. Appropriate dosages and...
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William Fahl, Arnold Ruoho, Minesh Mehta | P05246US
Technology
GLYCORANDOMIZATION AND PRODUCTION OF NOVEL VANCOMYCIN ANALOGS
The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the ...
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Jon Thorson | P04116US
Technology
Method For Evaluating The Solubility Of A Crystalline Substance In A Polymer
A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorp...
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Lian Yu, Geoff GZ Zhang, Jing Tao, Ye Sun, Markus Maegerlein | P140053US05
Technology
Reversible Natural Product Glycosyltransferase-catalyzed Reactions, Compounds And Related Methods
The present invention relates to methods of use of glycosyltransferases and related compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomol...
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Jon Thorson, Byron Griffith, Changsheng Zhang | P06427US