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Alexander disease (AxD) is a rare disease of the central nervous system characterized by formation of protein aggregates within astrocytes and disruption of growth or maintenance of the myelin sheath....
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Albee Messing, Tracy Hagemann | P170228US01

Technology

Blood-Brain Barrier Model

Accurately reproducing the blood-brain barrier in an in vitro setting has been a longstanding challenge. Current methods require the independent isolation of multiple cell types, and the quality of th...
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Eric Shusta, Clive Svendsen, Christian Weidenfeller | P06318US02

Technology

Genetic Testing for Acquired Peripheral Neuropathy in Dogs

Peripheral neuropathies are a diverse group of diseases marked by degeneration of the peripheral nervous system. These diseases affect both humans and animals. In humans, the most common form is Charc...
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Peter Muir, Susannah Sample, John Svaren | P160048US02

Technology

Research Tool for Protein Conformation Analysis

The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, Juda Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02

Technology

Recombinant Rhinovirus A16 for Human Inoculation Studies

Human inoculum strains of rhinoviruses have been used for more than 50 years to induce experimental colds to study disease mechanisms and to test the efficacy of antiviral drugs. Traditional inocula a...
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James Gern, Wai-Ming Lee | P170018US01

Technology

Animal Model of Brittle Bone Disease

Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
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Daniel Greenspan, Se-Jin Lee | P160036US01

Technology

Photoreceptor Scaffold for In Vitro Modeling and Transplantation Therapy

Photoreceptors are specialized cells that capture and convert light into signals that can be processed by the retina and visual centers of the brain. Supportive cells called the retinal pigment epithe...
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Zhenqiang Ma, Yei Hwan Jung, Michael Phillips, David Gamm, Shaoqin Gong | P160094US01

Technology

Rhinovirus-C Peptide for Development of Vaccines and Antivirals

Human rhinoviruses (species A, B and C) are responsible for the majority of upper respiratory tract infections (like the common cold) and many infections of the lower respiratory tract as well. Rhin...
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Ann Palmenberg, Marchel Hill, Kelly Watters, Michael Rossman, Yue Liu | P160341US02