UW-Madison researchers have developed a new method of performing dosimetry for radiation-based cancer therapeutics. Rather than performing dosimetry before treatment to determine the most effective am...
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Su-Chun Zhang, a world-renowned neuroscientist and pioneer in stem cell research, has developed a method for printing neural tissues that allows cells to form neural networks in vitro. The human brain...
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Approximately half of all diseases affect the function of ion channels in cell membranes. Testing the flow of ions and molecules through these membranes clearly is vital to drug discovery and research...
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Patch clamping is a well-known technique for investigating the movement of ions and molecules through cellular membranes via ion channels. To create an extremely high-resistance ‘gigaseal’ around ...
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The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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Patch clamping is a well known method for measuring the flow of ions and molecules through ion channels imbedded in the cellular membrane.  The method employs micropipettes, or similar microscale ape...
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UW-Madison researchers have developed a novel platform for macropinocytosis-mediated recyclable LYTACs, coined McR-TACs. This platform is capable of initiating macropinocytosis to drag proteins of int...
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UW-Madison researchers have developed a method for producing drug-loaded PEG copolymer micelles through crystalizing PEG in the presence of an amorphous copolymer and the hydrophobic drug. This proces...
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A UW-Madison researcher developed an E. coli strain for expressing the nucleic acid plasmid that serves as the active pharmaceutical ingredient (API) for GMP production of a prostate cancer vaccine. T...
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UW-Madison researchers have developed a new way to select protein and cyclic peptide binders of amyloid-β (Aβ) oligomers. This innovation uses a transcription factor that the inventors previously en...
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UW-Madison researchers have developed a method for differentiation of human pluripotent stem cells (hPSCs) into endothelial cells (ECs) resulting in a model having improved fidelity to BBB gene expres...
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A UW-Madison researcher has developed a web-based atlas of cell surface target (CST) protein expression across various cancer types. This system can be used to identify understudied drug targets for t...
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UW-Madison researchers have developed a universal botulinum neurotoxin production strain using Clostridium tetani. C. tetani ATCC 454 is an atoxic strain lacking the tetanus toxin gene (tent) as well ...
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UW-Madison researchers developed a novel method and plasmid construct for creating CAR T cells using CRISPR-Cas gene editing. They used a ribonucleic protein complex with guide RNAs and expressed Cas9...
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UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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A UW-Madison researcher has developed a rat model for studying the dynamic nature of the protein Tau, a protein implicated in numerous neurological diseases including Alzheimer’s and Parkinson’s d...
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UW-Madison researchers have developed an AI-based method for designing humanized CAR sequences. Using this method, they developed two novel humanized CD19 sequences that can be used for production of ...
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UW-Madison researchers have applied transposon technology to CRISPR-mediated gene targeting to create libraries of genetically modified bacteria displaying differentially expressed genes throughout th...
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A UW researcher has developed immune evading pluripotent stem cells by knocking down cell adhesion molecules in pluripotent stem cell lines. He differentiated those cells into cardiomyocytes or epithe...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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Schistosomiasis is an often-neglected tropical disease caused by blood flukes (helminths). The World Health Organization estimates that over 250 million people require preventive treatment for schisto...
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UW-Madison researchers have developed a simple, two-step process for creating a disaccharide handle useful as a linker in antibody-drug conjugation. The researchers recognized that the Endo-S2 enzyme ...
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