The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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A UW-Madison researcher has developed a rat model for studying the dynamic nature of the protein Tau, a protein implicated in numerous neurological diseases including Alzheimer’s and Parkinson’s d...
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UW-Madison researchers have developed an AI-based method for designing humanized CAR sequences. Using this method, they developed two novel humanized CD19 sequences that can be used for production of ...
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UW-Madison researchers have applied transposon technology to CRISPR-mediated gene targeting to create libraries of genetically modified bacteria displaying differentially expressed genes throughout th...
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A UW researcher has developed immune evading pluripotent stem cells by knocking down cell adhesion molecules in pluripotent stem cell lines. He differentiated those cells into cardiomyocytes or epithe...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as...
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Schistosomiasis is an often-neglected tropical disease caused by blood flukes (helminths). The World Health Organization estimates that over 250 million people require preventive treatment for schisto...
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UW-Madison researchers have developed a simple, two-step process for creating a disaccharide handle useful as a linker in antibody-drug conjugation. The researchers recognized that the Endo-S2 enzyme ...
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The element fluorine has acquired an ever-increasing prevalence in synthetic drugs and agrochemicals due to its positive impact on the metabolism, chemical stability, and modulating lipophilicity of a...
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UW-Madison researchers have developed a method of diagnosing cancer through detection of specific fragmentation patterns of cell free DNA in plasma. Their approach is distinctly focused on positioning...
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UW-Madison researchers have developed a method of stabilizing short antigenic peptides that act as vaccines against infectious disease or cancer. Peptides that bind major histocompatibility complex I ...
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UW-Madison researchers have developed a protein degrader that shuttles targeted extracellular protein into the lysosome using a cyclic peptide that binds to a cellular receptor attached to a binding m...
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UW-Madison researchers have developed a synthetic peptide through a single amino acid substitution and chemical conjugation of an aromatic molecule at the site of mutation that turns a peptide that bi...
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UW-Madison researchers have a Clostridium botulinum strain 62A that is a sporulating C. botulinum strain producing high levels of BoNT/A1. A bacterial stock was prepared from a single colony and seque...
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UW-Madison researchers have developed a high throughput peptide mapping platform by combining a plate-based sample preparation method with direct injection MS analysis. Protein samples are cleaned, re...
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UW-Madison researchers have developed photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improv...
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UW-Madison researchers have developed a method of identifying and characterizing DNA fragmentation patterns in circulating tumor cells using targeted circulating tumor cell DNA (ctDNA) panels. These r...
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UW-Madison researchers developed a novel class of molecules that bind cereblon (CRBN), a ubiquitin ligase. These molecules may be used in the development of PROTAC therapeutics. The researchers starte...
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Cell therapy is a novel and promising approach to treating diseases such as rheumatoid arthritis, atherosclerosis, acute ischemia, myocardial infarction, diabetes, graft versus host disease and cancer...
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UW-Madison researchers have developed a novel method for predicting optimal treatment responses in oncology patients based on DNA and RNA sequences in circulating tumor cells. They termed this new met...
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Rheumatoid factors (RFs) are antibodies that commonly develop in patients with rheumatoid arthritis (RA), an incurable autoimmune disease that affects ~1% of the population. RFs bind to IgG and other ...
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Su-Chun Zhang, a world-renowned neuroscientist and pioneer in stem cell research, has developed a method for printing neural tissues that allows cells to form neural networks in vitro. The human brain...
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A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
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UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researc...
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