Wisconsin Alumni Research Foundation

Technology

Research Tool for Protein Conformation Analysis

The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, Juda Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02

Technology

Yeast-Based Intein Platform for Drug Production

The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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Eric Shusta, Cathryn Marshall | P150056US02

Technology

Safer Influenza Vaccine from Replication-Knock Out Virus

Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
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Yoshihiro Kawaoka, Gabriele Neumann, Makoto Ozawa | P110003US02

Technology

Neoglycorandomization and Digitoxin Analogs

Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and ...
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Jon Thorson, Joseph Langenhan | P04455US

WARF