Search Results
317 Results for 'Research Tools'
PAGE 10 OF 13
Technology
Transgenic Rats Expressing Human Placental Alkaline Phosphatase
The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
Learn More
Learn More
Eric Sandgren, William Kisseberth, Jan Lohse, Phil Soriano | P01322US
Technology
Transgenic Mice Expressing Human Alkaline Phosphatase
The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
Learn More
Learn More
Eric Sandgren, William Kisseberth, Jan Lohse, Phil Soriano | P01323US
Technology
Transgenic Mice That Ubiquitously Express Enhanced Green Fluorescent Protein
The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
Learn More
Learn More
Eric Sandgren, William Kisseberth, Jan Lohse, Phil Soriano | P01324US
Technology
Bacterial Culture Collection from an Extreme Environment in Alaska
Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
Learn More
Learn More
Jo Handelsman, Patrick Schloss | P03154US
Technology
Monoclonal Antibody to Eukaryotic RNA Polymerase II
The enzyme RNA polymerase II synthesizes precursors to mRNAs and small nuclear RNAs. Sequence analysis of the largest subunit of RNA polymerase II has revealed an unusual heptapeptide repeat at the mo...
Learn More
Learn More
Richard Burgess, Nancy Thompson | P03157US
Technology
Unique, Full-Length Mouse cDNAs
The study of full-length cDNA clones is important for determining the structure and function of genes.
Learn More
Learn More
Christopher Bradfield | P03413US
Technology
Novel Assay for Measuring Stress-Induced CREB Phosphorylation
CREB is a transcription factor that has been implicated as a critical regulator of neuronal function and survival. Knockout mice lacking CREB exhibit a disease similar to ataxia telangiectasia, a neur...
Learn More
Learn More
Randal Tibbetts, Yuling Shi | P04048US
Technology
Rat Strain Showing Developmental Changes in Alternative Splicing of the Heart Protein Titin
Titin is a very large cardiac protein that determines the resting tension of the heart in rats. Isoforms of titin are generated by alternative splicing of a single titin gene. Titin in embryonic rat h...
Learn More
Learn More
Marion Greaser, Chad Warren, Paul Krzesinski | P04176US
Technology
Libraries of Bacterial Genomic DNA Isolated from Alaskan Soils
Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be brought into culture by standard techniques represent only ...
Learn More
Learn More
Jo Handelsman, Lynn Williamson | P04104US
Technology
Strain and Vector for Use with the Three Hybrid System
Three hybrid screens are used to detect RNA-protein interactions. A problem with three hybrid screens has been high background due to some cDNAs binding and activating transcription in the absen...
Learn More
Learn More
Marvin Wickens, Beilin Zhang | P97099US
Technology
Label-Free, Radio-Frequency Detection of DNA Hybridization at Microelectrodes
Most of today’s technologies for detecting DNA hybridization – the binding of a DNA strand to its complementary strand – require the use of fluorescent tags or other types of labels.
Learn More
Learn More
Daniel van der Weide, Robert Hamers, Wei Cai, John Peck | P03002US
Technology
Method and Device for Measuring Electrical Conductance of Membranes with a Radio Frequency Probe
Biological membranes, such as cell membranes, are intrinsically impermeable to ions and polar molecules. Thus, transport of ions through biological membranes requires special channel or pump proteins ...
Learn More
Learn More
Daniel van der Weide | P01413US
Technology
Heterogeneous Protein Foldamers Containing Alpha, Beta and Gamma Amino Acids
Foldamers are synthetic protein oligomers with discrete and predictable folding properties akin to those of natural proteins. They provide molecular tools to investigate large-molecule interactions su...
Learn More
Learn More
Samuel Gellman, Ahlke Hayen, Margaret Schmitt, Felix Ngassa | P02125US
Technology
HERG-Specific Antisera
The gene HERG1 encodes a potassium-selective ion channel important in maintaining normal cardiac rhythm and cell growth.
Learn More
Learn More
Gail Robertson, Barry London, Elon Roti Roti, Samantha Delfosse, Eugenia Jones | P04019US
Technology
Controllable Murine Models of First Pass Metabolism
The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
Learn More
Learn More
Christopher Bradfield, Jacqueline Walisser, Tami Thomae | P04330US
Technology
A Polyclonal Antibody Directed Against the C-Terminus of HERG
HERG (human ether-a-go-go-related gene) encodes a potassium ion channel important for maintaining normal cardiac rhythm and cell growth.
Learn More
Learn More
Craig January, Qiuming Gong, Zhengfeng Zhou | P05253US
Technology
10,000 Sequenced Mouse Genomic Clones Derived From a CpG Library
CpG islands are areas of DNA containing a high CpG content, which often correspond to promoter regions.
Learn More
Learn More
Peggy Farnham | P04394US
Technology
HERG CDNA with Native PolyA Tail
The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
Learn More
Learn More
Gail Robertson, Eugenia Jones, Blake Anson | P05401US
Technology
Stable Cell Lines Expressing hERG1a and 1b
Cardiac IKr channels are targets associated with inherited and acquired long QT syndrome (LQTS), a disorder that can lead to ventricular arrhythmias. Previously, IKr channels were thought to be compos...
Learn More
Learn More
Gail Robertson, Eugenia Jones, Jinling Wang | P03380US
Technology
Plasma-Enhanced Functionalization of Carbon-Containing Substrates
Before DNA or proteins can be attached to a surface during the making of microarrays, the surface must be functionalized, i.e., chemically prepared to carry functional groups capable of...
Learn More
Learn More
Ferencz Denes, Sorin Manolache, Luis Emilio Cruz-Barba, Max Lagally, Bradley Larson | P03334US
Technology
Human Heart Sodium Channel Beta1 Subunit (SCNB1)
The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
Learn More
Learn More
Jonathan Makielski, Bin Ye | P03207US
Technology
Bacterial Genomic Libraries from Alaskan Soils (AK 9-13 and 16)
Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be cultured using standard techniques represent only a small f...
Learn More
Learn More
Jo Handelsman, Lynn Williamson, Heather Allen | P05158US
Technology
Microfluidics Platform and Method That Mimic the Cellular Environment
Most biochemical interactions are studied in solutions containing dilute concentrations of molecules. However, the complexity of the cellular environment makes it difficult to compare the results of s...
Learn More
Learn More
David Beebe, Jaisree Moorthy, Richard Burgess | P04153US
Technology
Immortalized Cells from the Mouse Urogenital Sinus and Adult Mouse Prostate
No well-characterized prostate stromal cell lines currently exist.
Learn More
Learn More
Wade Bushman | P03405US
Technology
Monoclonal Antibodies Specific for the Cytoplasmic Gamma-actin Isoform
The six mammalian actin genes encode a highly conserved family of cytoskeletal protein isoforms important in cell structure, mechanical stability, and motility. Actin isoforms exhibit tissue-specific ...
Learn More
Learn More
James Ervasti, Laurin Hanft | P05366US