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270 Results for 'Therapeutics & Vaccines'
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Technology
New and More Potent UGM Inhibitors for Treating Tuberculosis, Other Microbial Infections
Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for eight million human infections and two million deaths worldwide each year. M. tuberculosis infections can be treated...
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Laura Kiessling, Valerie Winton, Alexander Justen | P160093US02
Technology
Peptides to Treat Alzheimer’s Disease
Amyloid-beta (Aβ) peptides play a crucial role in Alzheimer’s disease – they are a main component of the toxic amyloid plaques found in patients’ brains. Aβ is so dangerous because it can aggr...
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Regina Murphy, Jeffrey Johnson, Patricia Cho, Xiaomeng Lu | P140391US02
Technology
Skin Whitening Agent(s)
The global cosmetics industry is a $460 billion dollar market with the skin whitening sector valued at $381 million in 2014. This growing market is projected to increase at a CAGR of 11.7%, reaching $...
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Cheng-chen Huang, Aaron Monte | T140007WO01
Technology
Warfarin Promoter
Warfarin is a “first-generation” anticoagulant that has been widely used as a multiple feeding rodenticide for more than 60 years. The prolonged use of warfarin as a rodenticide has, according to ...
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David Lewis, Michael Caldwell | T100001US02
Technology
Novel Subtype of Botulinum Toxin for Prolonged Effectiveness
Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus.
Several di...
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Eric Johnson, Mark Jacobson, Guangyun Lin, William Tepp, Raymond Stevens, Jerome Dupuy, Paul Stenmark | P09050US02
Technology
Long-Lasting, Non-Narcotic Protein for Treatment of Acute or Chronic Pain
Millions of people in the U.S. suffer from chronic pain each year. Narcotic-based medications commonly are given for pain relief, but they are not always effective and can lead to addiction.Botulinum ...
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Eric Johnson, Sabine Pellett, William Tepp, Tony Yaksh, Marc Marino, Qinghao Xu | P130093US02
Technology
Increasing Red Blood Cell Production
Maintaining an adequate supply of oxygen to tissue is necessary for survival. The oxygen-carrying capacity of blood is governed by the concentration of red blood cells (erythrocytes). It is critical t...
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Emery Bresnick, Yoon A Kang, Skye McIver | P130326US02
Technology
Treating Iron Overload with Block Copolymers
Iron overload or hemochromatosis is a disease marked by an accumulation of iron in the blood. It typically occurs in subjects (e.g., anemia patients) receiving chronic infusions of red blood cells. Th...
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May Xiong, Zhi Liu, Yan Wang | P140395US02
Technology
Generic Drug to Treat and Prevent Macular Degenerative Diseases
More than 30 million people suffer from age-related macular degeneration (AMD), the most common cause of permanent vision loss among older adults. Few treatment options are available for AMD, or for j...
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Aparna Lakkaraju, Kimberly Toops, Li Xuan Tan | P140282US02
Technology
Treating Absence Epilepsy with Ganaxolone
Absence epilepsy (formerly known as ‘petit mal epilepsy’) afflicts thousands of people worldwide, many of them children. It is characterized by nonconvulsive seizures, loss of consciousness, glass...
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Mathew Jones, Chiara Cirelli, Kile Mangan, Aaron Nelson | P140051US02
Technology
Hormone Analogs for Treating Hypoparathyroidism
The proper functioning of cells depends on information traveling from the extracellular environment to the cytoplasm. Most signals must be conveyed via proteins that span the cellular membrane. Many o...
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Samuel Gellman, Ross Cheloha, Thomas Gardella | P130312US03
Technology
Non-Natural Peptides for Treating Diabetes
Diabetes mellitus continues to be a chronic public health issue despite the availability of injectable insulin since the 1920s. Finding alternative treatments is the subject of intense research. In re...
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Samuel Gellman, Lisa Johnson, Alan Attie, Alan Saghatelian, Mark Keller | P130310US02
Technology
Novel Subtype of Botulinum Toxin for Pharmaceutical Use
Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus.The bacteria ...
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Eric Johnson, Kristin Marshall, Sabine Pellett, Marite Bradshaw | P06269US
Technology
Influenza Variant Grows Well in CHO Cells
Vaccines against influenza and other viruses can be grown in Chinese Hamster Ovary (CHO) cells. Problematically, an influenza virus that is made by combining H1N1 and PR8 strains, and that is recommen...
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Yoshihiro Kawaoka, Makoto Ozawa | P100246US02
Technology
Neuraminidase-Deficient Live Influenza Vaccine
Influenza infects up to 20 percent of the world’s population every year, causing 500,000 deaths and costing tens of billions of dollars in medical expenses. Influenza A virus, which causes pandemics...
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Yoshihiro Kawaoka, Masato Hatta | P07044US
Technology
Treating Fungal Infections with New Forazoline Compounds
Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02
Technology
Treating Staph Infections, Toxic Shock Syndrome by Disrupting Bacteria Quorum Sensing
‘Staph’ infections, particularly by Staphylococcus aureus strains, can cause skin ailments and more serious conditions like heart valve inflammation and toxic shock syndrome. These strains also ar...
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Helen Blackwell, Danielle Wittenwyler, Yiftah Tal Gan | P130070US02
Technology
Antiviral Peptides and Methods for Inducing Cellular Resistance to Infection
Influenza virus causes millions of infections each year worldwide. Human parainfluenza virus (PIV) types 1,2,3 and respiratory syncytial virus (RSV) types A and B are the major viral pathogens respons...
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Curtis Brandt, Hermann Bultmann | P03289US
Technology
Treating Multiple Sclerosis with UV Light
Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
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Hector DeLuca, Yanping Wang, Steven Marling | P120376US02
Technology
Vaccine for Fungal Infections
There are no commercial vaccines against fungi. Infections like aspergillosis and Valley Fever can be life-threatening, particularly in immune-compromised patients. These patients also are more vulner...
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Bruce Klein, Theodore Brandhorst, Thomas Sullivan, Marcel Wuethrich | P130116US02
Technology
Provoking Anti-Tumor Immune Response with Rhamnose
One promising approach to cancer treatment is to leverage the immune system. Specifically, tumors can be ‘tagged’ with foreign antigens that attract the body’s defensive antibodies. The antibodi...
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Laura Kiessling, Rachael Sheridan, Jonathan Hudon | P120290US02
Technology
Potential for Vaccine Against Johne’s Disease
Johne’s disease, or paratuberculosis, is a chronic and usually fatal wasting disease that is found worldwide and impacts more than half of the dairy herds in the U.S. alone. It costs the ruminant in...
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Adel Talaat | P130200US02
Technology
Safer Ebola Virus and Vaccines
Ebola is the deadliest virus on earth. It has caused death in 90 percent of cases during some outbreaks, afflicting human and great ape populations in tropical Africa. The virus is highly contagious i...
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Yoshihiro Kawaoka, Peter Halfmann, Jin Hyun Kim | P07377US02
Technology
Protecting Ovaries from Chemotherapy Damage Using Proteasome Inhibitors
Primary ovary insufficiency (POI) caused by chemotherapy treatment is experienced by many cancer survivors, including up to 40 percent of reproductive-age breast cancer survivors and eight percent of ...
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Sana Salih, Elon Roti Roti | P130111US02
Technology
Portable Carbon Monoxide Source for Therapy and Organ Delivery
The inhalation of small amounts of carbon monoxide (CO) by a transplant organ recipient has been shown to significantly improve transplant outcomes. Currently, medical grade CO is only available in hi...
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Tye Gribb, Duncan Bathe | P120148US01