Wisconsin Alumni Research Foundation

Technology

Nylon-3 Polymers Active Against Clostridium Difficile

Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
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Samuel Gellman, Runhui Liu, Bernard Weisblum, Shonna McBride | P150214US02

Technology

Peptides to Treat Alzheimer’s Disease

Amyloid-beta (Aβ) peptides play a crucial role in Alzheimer’s disease – they are a main component of the toxic amyloid plaques found in patients’ brains. Aβ is so dangerous because it can aggr...
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Regina Murphy, Jeffrey Johnson, Patricia Cho, Xiaomeng Lu | P140391US02

Technology

Skin Whitening Agent(s)

The global cosmetics industry is a $460 billion dollar market with the skin whitening sector valued at $381 million in 2014. This growing market is projected to increase at a CAGR of 11.7%, reaching $...
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Cheng-chen Huang, Aaron Monte | T140007WO01

Technology

Warfarin Promoter

Warfarin is a “first-generation” anticoagulant that has been widely used as a multiple feeding rodenticide for more than 60 years. The prolonged use of warfarin as a rodenticide has, according to ...
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David Lewis, Michael Caldwell | T100001US02

Technology

Novel Subtype of Botulinum Toxin for Prolonged Effectiveness

Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus. Several di...
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Eric Johnson, Mark Jacobson, Guangyun Lin, William Tepp, Raymond Stevens, Jerome Dupuy, Paul Stenmark | P09050US02

Technology

Increasing Red Blood Cell Production

Maintaining an adequate supply of oxygen to tissue is necessary for survival. The oxygen-carrying capacity of blood is governed by the concentration of red blood cells (erythrocytes). It is critical t...
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Emery Bresnick, Yoon A Kang, Skye McIver | P130326US02

Technology

Treating Iron Overload with Block Copolymers

Iron overload or hemochromatosis is a disease marked by an accumulation of iron in the blood. It typically occurs in subjects (e.g., anemia patients) receiving chronic infusions of red blood cells. Th...
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May Xiong, Zhi Liu, Yan Wang | P140395US02

Technology

Hormone Analogs for Treating Hypoparathyroidism

The proper functioning of cells depends on information traveling from the extracellular environment to the cytoplasm. Most signals must be conveyed via proteins that span the cellular membrane. Many o...
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Samuel Gellman, Ross Cheloha, Thomas Gardella | P130312US03

Technology

Non-Natural Peptides for Treating Diabetes

Diabetes mellitus continues to be a chronic public health issue despite the availability of injectable insulin since the 1920s. Finding alternative treatments is the subject of intense research. In re...
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Samuel Gellman, Lisa Johnson, Alan Attie, Alan Saghatelian, Mark Keller | P130310US02

Technology

Novel Subtype of Botulinum Toxin for Pharmaceutical Use

Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus.The bacteria ...
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Eric Johnson, Kristin Marshall, Sabine Pellett, Marite Bradshaw | P06269US

Technology

Influenza Variant Grows Well in CHO Cells

Vaccines against influenza and other viruses can be grown in Chinese Hamster Ovary (CHO) cells. Problematically, an influenza virus that is made by combining H1N1 and PR8 strains, and that is recommen...
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Yoshihiro Kawaoka, Makoto Ozawa | P100246US02

Technology

Neuraminidase-Deficient Live Influenza Vaccine

Influenza infects up to 20 percent of the world’s population every year, causing 500,000 deaths and costing tens of billions of dollars in medical expenses. Influenza A virus, which causes pandemics...
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Yoshihiro Kawaoka, Masato Hatta | P07044US

Technology

Treating Fungal Infections with New Forazoline Compounds

Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02

Technology

Treating Multiple Sclerosis with UV Light

Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
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Hector DeLuca, Yanping Wang, Steven Marling | P120376US02

Technology

Vaccine for Fungal Infections

There are no commercial vaccines against fungi. Infections like aspergillosis and Valley Fever can be life-threatening, particularly in immune-compromised patients. These patients also are more vulner...
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Bruce Klein, Theodore Brandhorst, Thomas Sullivan, Marcel Wuethrich | P130116US02

Technology

Provoking Anti-Tumor Immune Response with Rhamnose

One promising approach to cancer treatment is to leverage the immune system. Specifically, tumors can be ‘tagged’ with foreign antigens that attract the body’s defensive antibodies. The antibodi...
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Laura Kiessling, Rachael Sheridan, Jonathan Hudon | P120290US02

Technology

Potential for Vaccine Against Johne’s Disease

Johne’s disease, or paratuberculosis, is a chronic and usually fatal wasting disease that is found worldwide and impacts more than half of the dairy herds in the U.S. alone. It costs the ruminant in...
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Adel Talaat | P130200US02

Technology

Safer Ebola Virus and Vaccines

Ebola is the deadliest virus on earth. It has caused death in 90 percent of cases during some outbreaks, afflicting human and great ape populations in tropical Africa. The virus is highly contagious i...
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Yoshihiro Kawaoka, Peter Halfmann, Jin Hyun Kim | P07377US02

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