Search Results
262 Results for 'Therapeutics & Vaccines'
PAGE 9 OF 11
Technology
Non-Natural Peptides for Treating Diabetes
Diabetes mellitus continues to be a chronic public health issue despite the availability of injectable insulin since the 1920s. Finding alternative treatments is the subject of intense research. In re...
Learn More
Learn More
Samuel Gellman, Lisa Johnson, Alan Attie, Alan Saghatelian, Mark Keller | P130310US02
Technology
Novel Subtype of Botulinum Toxin for Pharmaceutical Use
Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus.
The bacteri...
Learn More
Learn More
Eric Johnson, Kristin Marshall, Sabine Pellett, Marite Bradshaw | P06269US
Technology
Influenza Variant Grows Well in CHO Cells
Vaccines against influenza and other viruses can be grown in Chinese Hamster Ovary (CHO) cells. Problematically, an influenza virus that is made by combining H1N1 and PR8 strains, and that is recommen...
Learn More
Learn More
Yoshihiro Kawaoka, Makoto Ozawa | P100246US02
Technology
Neuraminidase-Deficient Live Influenza Vaccine
Influenza infects up to 20 percent of the world’s population every year, causing 500,000 deaths and costing tens of billions of dollars in medical expenses. Influenza A virus, which causes pandemics...
Learn More
Learn More
Yoshihiro Kawaoka, Masato Hatta | P07044US
Technology
Treating Fungal Infections with New Forazoline Compounds
Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
Learn More
Learn More
Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02
Technology
Treating Staph Infections, Toxic Shock Syndrome by Disrupting Bacteria Quorum Sensing
‘Staph’ infections, particularly by Staphylococcus aureus strains, can cause skin ailments and more serious conditions like heart valve inflammation and toxic shock syndrome. These strains...
Learn More
Learn More
Helen Blackwell, Danielle Wittenwyler, Yiftah Tal Gan | P130070US02
Technology
Antiviral Peptides and Methods for Inducing Cellular Resistance to Infection
Influenza virus causes millions of infections each year worldwide. Human parainfluenza virus (PIV) types 1,2,3 and respiratory syncytial virus (RSV) types A and B are the major viral pathogens respons...
Learn More
Learn More
Curtis Brandt, Hermann Bultmann | P03289US
Technology
Treating Multiple Sclerosis with UV Light
Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
Learn More
Learn More
Hector DeLuca, Yanping Wang, Steven Marling | P120376US02
Technology
Vaccine for Fungal Infections
There are no commercial vaccines against fungi. Infections like aspergillosis and Valley Fever can be life-threatening, particularly in immune-compromised patients. These patients also are more vulner...
Learn More
Learn More
Bruce Klein, Theodore Brandhorst, Thomas Sullivan, Marcel Wuethrich | P130116US02
Technology
Provoking Anti-Tumor Immune Response with Rhamnose
One promising approach to cancer treatment is to leverage the immune system. Specifically, tumors can be ‘tagged’ with foreign antigens that attract the body’s defensive antibodies. The antibodi...
Learn More
Learn More
Laura Kiessling, Rachael Sheridan, Jonathan Hudon | P120290US02
Technology
Potential for Vaccine Against Johne’s Disease
Johne’s disease, or paratuberculosis, is a chronic and usually fatal wasting disease that is found worldwide and impacts more than half of the dairy herds in the U.S. alone. It costs the ruminan...
Learn More
Learn More
Adel Talaat | P130200US02
Technology
Safer Ebola Virus and Vaccines
Ebola is the deadliest virus on earth. It has caused death in 90 percent of cases during some outbreaks, afflicting human and great ape populations in tropical Africa. The virus is highly contagious i...
Learn More
Learn More
Yoshihiro Kawaoka, Peter Halfmann, Jin Hyun Kim | P07377US02
Technology
Protecting Ovaries from Chemotherapy Damage Using Proteasome Inhibitors
Primary ovary insufficiency (POI) caused by chemotherapy treatment is experienced by many cancer survivors, including up to 40 percent of reproductive-age breast cancer survivors and eight percent of ...
Learn More
Learn More
Sana Salih, Elon Roti Roti | P130111US02
Technology
Portable Carbon Monoxide Source for Therapy and Organ Delivery
The inhalation of small amounts of carbon monoxide (CO) by a transplant organ recipient has been shown to significantly improve transplant outcomes. Currently, medical grade CO is only available in hi...
Learn More
Learn More
Tye Gribb, Duncan Bathe | P120148US01
Technology
Vitamin D Analogs “1D-QM” and “1D-QMS” for Cancer, Bone Disease Therapy
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Learn More
Hector DeLuca, Lori Plum, Rafal Sicinski, Izabela Sibilska-Kaminski | P120085US02
Technology
Vitamin D Analogs “2EG” and “T-2EG-S” for Treating Cancer and Bone Disease
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Learn More
Hector DeLuca, Lori Plum, Rafal Sicinski, Izabela Sibilska-Kaminski | P120086US02
Technology
Vitamin D Analogs “3D-QM” and “3D-QMS” for Treating Cancer and Bone Diseases
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Learn More
Hector DeLuca, Lori Plum, Rafal Sicinski, Izabela Sibilska-Kaminski | P120087US02
Technology
Preventing Septic Shock and Death with Peptide Antibodies
More than half a million people develop severe sepsis and 215,000 die each year, costing billions of dollars in the Unites States alone. Sepsis is a type of severe inflammatory response syndrome (SIRS...
Learn More
Learn More
Mark Cook, Jordan Sand, Daniel Butz | P120312US01
Technology
Crystallized Vitamin D Analogs “MET-1” and “MET-2”
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Learn More
Hector DeLuca, Agnieszka Flores, James Thoden, Hazel Holden | P120098US02
Technology
Anti-Anxiety Pharmaceuticals with Reduced Side Effects
According to the National Institute of Mental Health, anxiety disorders affect approximately 40 million American adults. These chronic illnesses can severely decrease a patient’s quality of life. An...
Learn More
Learn More
James Cook, Qi Huang, Xiaohui He, Xiaoyan Li, Jianming Yu, Dongmei Han | T02017US
Technology
Safer Influenza Vaccine from Replication-Knock Out Virus
Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
Learn More
Learn More
Yoshihiro Kawaoka, Gabriele Neumann, Makoto Ozawa | P110003US02
Technology
Vitamin D Analogs for Treating Bone Cancers and Diseases
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Learn More
Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Izabela Sibilska-Kaminski, Rafal Sicinski | P100358US03
Technology
Vitamin D Analog “DA2HE” to Treat and Prevent Polyps, Hyperplastic Intestinal Disorders
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Learn More
Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Agnieszka Glebocka | P120347US02
Technology
Library of Glycosylated Chlorambucil Analogs for Cancer Treatment
Many of the compounds used in drug discovery by pharmaceutical companies consist of a central core structure (aglycon) and various sugar (glycosyl) attachments. Because the sugar moieties of many of t...
Learn More
Learn More
Jon Thorson, Randal Goff | P110076US02
Technology
Crystallized Vitamin D Compound Known as “20DCM”
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Learn More
Hector DeLuca, Agnieszka Glebocka, James Thoden, Hazel Holden | P100319US02