Wisconsin Alumni Research Foundation

Technology

Novel Subtype of Botulinum Toxin for Pharmaceutical Use

Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus. The bacteri...
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Eric Johnson, Kristin Marshall, Sabine Pellett, Marite Bradshaw | P06269US

Technology

Influenza Variant Grows Well in CHO Cells

Vaccines against influenza and other viruses can be grown in Chinese Hamster Ovary (CHO) cells. Problematically, an influenza virus that is made by combining H1N1 and PR8 strains, and that is recommen...
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Yoshihiro Kawaoka, Makoto Ozawa | P100246US02

Technology

Neuraminidase-Deficient Live Influenza Vaccine

Influenza infects up to 20 percent of the world’s population every year, causing 500,000 deaths and costing tens of billions of dollars in medical expenses. Influenza A virus, which causes pandemics...
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Yoshihiro Kawaoka, Masato Hatta | P07044US

Technology

Treating Fungal Infections with New Forazoline Compounds

Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02

Technology

Treating Multiple Sclerosis with UV Light

Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
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Hector DeLuca, Yanping Wang, Steven Marling | P120376US02

Technology

Vaccine for Fungal Infections

There are no commercial vaccines against fungi. Infections like aspergillosis and Valley Fever can be life-threatening, particularly in immune-compromised patients. These patients also are more vulner...
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Bruce Klein, Theodore Brandhorst, Thomas Sullivan, Marcel Wuethrich | P130116US02

Technology

Provoking Anti-Tumor Immune Response with Rhamnose

One promising approach to cancer treatment is to leverage the immune system. Specifically, tumors can be ‘tagged’ with foreign antigens that attract the body’s defensive antibodies. The antibodi...
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Laura Kiessling, Rachael Sheridan, Jonathan Hudon | P120290US02

Technology

Safer Ebola Virus and Vaccines

Ebola is the deadliest virus on earth. It has caused death in 90 percent of cases during some outbreaks, afflicting human and great ape populations in tropical Africa. The virus is highly contagious i...
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Yoshihiro Kawaoka, Peter Halfmann, Jin Hyun Kim | P07377US02

Technology

Crystallized Vitamin D Analogs “MET-1” and “MET-2”

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
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Hector DeLuca, Agnieszka Flores, James Thoden, Hazel Holden | P120098US02

Technology

Anti-Anxiety Pharmaceuticals with Reduced Side Effects

According to the National Institute of Mental Health, anxiety disorders affect approximately 40 million American adults. These chronic illnesses can severely decrease a patient’s quality of life. An...
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James Cook, Qi Huang, Xiaohui He, Xiaoyan Li, Jianming Yu, Dongmei Han | T02017US

Technology

Safer Influenza Vaccine from Replication-Knock Out Virus

Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
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Yoshihiro Kawaoka, Gabriele Neumann, Makoto Ozawa | P110003US02

Technology

Vitamin D Analogs for Treating Bone Cancers and Diseases

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Izabela Sibilska-Kaminski, Rafal Sicinski | P100358US03

Technology

Crystallized Vitamin D Compound Known as “20DCM”

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
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Hector DeLuca, Agnieszka Glebocka, James Thoden, Hazel Holden | P100319US02

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