Wisconsin Alumni Research Foundation

Technology

Knockout of GFAP In the Mouse (Model tm1Mes)

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01

Technology

Mouse Models for Protein Granule Diseases

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
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Wei Guo | P210193US01

Technology

Plasmids And Cell Lines Expressing The DMPK 3'UTR

The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
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Mani Mahadevan, Jeffrey Amack | P210221US01

Technology

Isogenic Blood-Brain Barrier Model

A method of creating an isogenic multicellular blood-brain barrier model from iPSCs is disclosed.
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Eric Shusta, Scott Canfield, Clive Svendsen, Gad Vatine, Sean Palecek | P160286US02

Technology

Rat Model of Alexander Disease

Alexander disease (AxD) is a rare disease of the central nervous system characterized by formation of protein aggregates within astrocytes and disruption of growth or maintenance of the myelin sheath....
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Albee Messing, Tracy Hagemann | P170228US01

Technology

Blood-Brain Barrier Model

Accurately reproducing the blood-brain barrier in an in vitro setting has been a longstanding challenge. Current methods require the independent isolation of multiple cell types, and the quality of th...
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Eric Shusta, Clive Svendsen, Christian Weidenfeller | P06318US02

Technology

Animal Model of Brittle Bone Disease

Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
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Daniel Greenspan, Se-Jin Lee | P160036US01

Technology

Adapted Rhinovirus C for Maximum Virus Yield

Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02

Technology

Ringworm Fungal Strain for Infection Studies

Microsporum canis is a skin fungal pathogen that causes dermatophytosis (ringworm) most commonly in cats and dogs. Dermatophytosis clinical trials are lengthy and complicated because the nature of the...
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Douglas DeBoer, Karen Moriello | P140194US01

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