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71 Results for 'Microfluidics'
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Technology
Hybrid Electrostatic Actuator
Hongrui Jiang, Alireza Ousati Ashtiani | P190157US01
Technology
Method And Device For Creating Organotypic Lumen Models In A Microwell Plate
Patrick McMinn, David Beebe | P190284US01
Technology
Microfluidic Device And Method Of Assaying For Immune Cell Exhaustion Using Same
David Beebe, Patrick McMinn, Jose Ayuso, Maria Virumbrales-Munoz | P200131US01
Technology
Volume-Free Reagent Addition And Exclusion-Based Sample Preparation For Streamlined Multi-Step Assays
David Beebe, Joshua Lang, Duane Juang, Scott Berry, Tamara Rodems | P190228US02
Technology
Open Microfluidic System And Various Functional Arrangements Therefore
David Beebe, Chao Li, Duane Juang | P190342US02
Technology
Systems And Methods For Undermedia Repellency
David Beebe, Chao Li, Jiaquan Yu, Theodorus de Groot | P170307US02
Technology
Platform And Method For Multi-Variable Screening
David Beebe, Duane Juang, Jiaquan Yu, Jo Handelsman | P180306US01
Technology
Microfluidic Device for Rapid Nucleic Acid Isolation and Purification
Extraction and isolation of nucleic acids from biological samples is an essential prerequisite for further amplification, detection and quantification of specific genetic sequences. The first step in ...
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David Beebe, Scott Berry | P100050US01
Technology
New Gradient-Based Cell Labeling Method Maintains Location Information During Downstream Analysis
Cellular ecology is a major factor in processes like cell signaling and transport as well as in the development and progression of systemic diseases like cancer. In situ, in vitro studies are becoming...
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David Beebe, Erwin Berthier, Mary Regier | P150171US01
Technology
Streamlined Design for Transferring Analytes
Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01
Technology
Circulating Tumor Cell Assay Using Simple Blood Draw
Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
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David Beebe, Joshua Lang, Ben Casavant, Scott Berry, Lindsay Strotman | P130171US01
Technology
Microwell Moat Prevents Spillover
The ability to study single cells has become indispensable, helping researchers identify characteristics and behaviors otherwise hidden using population averages. By obtaining multiple measures per ce...
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Jay Warrick, John Yin, Stephen Lindsay | P120353US01
Technology
Coupling Microfluidic Devices Yields Physiologically Relevant Micro-Environment for Cellular Assays
Cellular interactions and signaling in multicellular organisms involve complex pathways that can be difficult to study when using macroscale in vitro culture systems, in part because traditional macro...
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David Beebe, Jay Warrick | P08041US
Technology
Device Uses Air Gap for Easier Fraction Isolation
Isolating analytes from complex biological samples is one of the most crucial steps in many areas of biological research and clinical diagnostics. Paramagnetic particles (PMPs) or beads are important ...
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David Beebe, Scott Berry | P130107US01
Technology
Low-Waste and Contamination Device for Isolating Cells from a Biological Sample
For diagnosis and research it often is necessary to isolate a subset of cells from a sample that contains bodily fluids, contaminants, tissue and other types of cells. For example, determining a pati...
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David Beebe, Scott Berry, David Guckenberger, Ben Casavant | P120222US01
Technology
Snap-On Microfluidic Lid for Handheld Diagnostics and Chemical Tests
Investigation of cells, biochemicals and other samples by microfluidic devices stands to aid a full spectrum of research, from global HIV initiatives to the development of new drugs. Such devices prov...
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David Beebe, Erwin Berthier, Eric Sackmann, Peter Cavnar, David Guckenberger | P110044US01
Technology
Fast, Flexible Platform for Handheld Microfluidic Cell Assays
Identifying pathways involved in human diseases is the first step in the discovery of targets for therapy and diagnostics. Cell-based assays conducted in vitro are powerful tools in this process. Reco...
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Erwin Berthier, David Guckenberger, David Beebe, Peter Cavnar | P120238US01
Technology
Handheld Cell Maintenance and Assay Device with Functional Microfluidic Lid
The cellular-scale engineering that undergirds microfluidic systems has provided researchers with efficient tools for the analysis and manipulation of cells in vitro minisculo. Methods and devices ref...
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David Beebe, David Guckenberger, Peter Cavnar, Erwin Berthier | P110339US01
Technology
Achieving Precision Laminar Flow for Biological Microfluidics
Despite the growing interest in the natural interactions between different cellular compartments— and the increasing need to model these phenomena in vitro—no method currently in practice in biolo...
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David Beebe, Jay Warrick, Erwin Berthier | P100313US01
Technology
Microfluidic Device for Drug Delivery
Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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David Beebe, Michael MacDonald, David Eddington, Glennys Mensing | P04240US
Technology
Autonomous Self-Regulating Microfluidic System
Currently, no simple methods for the economical construction of complex microsystems exist. Some feedback systems have been constructed, but their complicated fabrication hinders their application.
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David Beebe, Jeffrey Moore, Robin Liu, David Eddington | P01314US
Technology
Improved Infrared-Responsive Hydrogel for Use in Microfluidics and Optics
Responsive hydrogels can respond to external stimuli such as temperature, pH, photons and antigens, which makes them applicable as functional materials in drug/gene delivery devices, microlenses and s...
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Hongrui Jiang, Chi-Wei Lo, Difeng Zhu | P120025US01
Technology
Improved Self-Loading Microfluidic Device for Determining Effective Antibiotic Dose and Other Chemical and Biological Assays
The minimum inhibitory concentration (MIC) of a compound is the lowest dose that prevents the growth of a cell during a set time interval. Because of the increase in antibiotic-resistant bacteria and ...
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Douglas Weibel, Nathaniel Cira | P110347US01
Technology
Method and Structure for Microfluidic Flow Guiding
Microfluidic devices are miniature systems that pump, mix, monitor and control small quantities of liquids. These systems have a number of applications, including painless drug delivery and analysis o...
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David Beebe, Jeffrey Moore, Bin Zhao | P01118US
Technology
Device for Efficiently Extracting a Fraction Containing Nucleic Acids or Other Desired Material from a Biological Sample
Effective isolation of nucleic acids from biological samples is an essential prerequisite for efficient downstream amplification, detection and quantification of specific genetic sequences via quantit...
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David Beebe, Scott Berry, Lindsay Strotman, Richard Burgess | P110080US01