A deformable well structure for a microtiter plate and method are provided. The deformable well structure includes a sample container defining a well for receiving a sample therein. The sample receive...
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A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower...
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A device and method are provided to facilitate the handling of a volume or fluid. The device includes an elongated tube having an open first end and a second end. The tube defines a reservoir for rece...
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A method and a device are provided for facilitating the disaggregation of a plurality of solid phase substrate as the plurality of solid phase substrate are transferred from a first location to a seco...
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A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a centr...
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A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid there...
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A hybrid electrostatic actuator for use in conjunction with microfluidic devices, microlenses, optical irises and flat panel displays is provided. The hybrid electrostatic actuator includes a substrat...
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A method and device of creating a lumen model in a microwell plate defining a well is provided. A rod is inserted through the well of the microwell plate and the well is filled with a polymerizable ma...
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Systems, methods, compositions of matter, and kits for undermedia repellency are disclosed. In some cases, these involve a first volume of a first liquid presented in a second volume of a second liqui...
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An open microfluidic system is provided. The open microfluidic system including the extreme wettability of exclusive liquid repellency (ELR), open microchannels with high lateral resolution and low pr...
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A microfluidic device and method of assaying for immune cell exhaustion therewith are provided. The microfluidic device includes a moveable rod positioned across a chamber of a microfluidic device adj...
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A method of sample preparation for streamlined multi-step assays is provided. The method includes the step of providing a microfluidic device including a reservoir defined by a surface configured to r...
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A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating w...
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Extraction and isolation of nucleic acids from biological samples is an essential prerequisite for further amplification, detection and quantification of specific genetic sequences. The first step in ...
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Cellular ecology is a major factor in processes like cell signaling and transport as well as in the development and progression of systemic diseases like cancer. In situ, in vitro studies are becoming...
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Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
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The ability to study single cells has become indispensable, helping researchers identify characteristics and behaviors otherwise hidden using population averages. By obtaining multiple measures per ce...
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Cellular interactions and signaling in multicellular organisms involve complex pathways that can be difficult to study when using macroscale in vitro culture systems, in part because traditional macro...
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Isolating analytes from complex biological samples is one of the most crucial steps in many areas of biological research and clinical diagnostics. Paramagnetic particles (PMPs) or beads are important ...
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For diagnosis and research it often is necessary to isolate a subset of cells from a sample that contains bodily fluids, contaminants, tissue and other types of cells. For example, determining a pati...
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Investigation of cells, biochemicals and other samples by microfluidic devices stands to aid a full spectrum of research, from global HIV initiatives to the development of new drugs. Such devices prov...
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The cellular-scale engineering that undergirds microfluidic systems has provided researchers with efficient tools for the analysis and manipulation of cells in vitro minisculo. Methods and devices ref...
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Identifying pathways involved in human diseases is the first step in the discovery of targets for therapy and diagnostics. Cell-based assays conducted in vitro are powerful tools in this process. Reco...
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Despite the growing interest in the natural interactions between different cellular compartments— and the increasing need to model these phenomena in vitro—no method currently in practice in biolo...
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