Wisconsin Alumni Research Foundation

Technology

Lesion Volume Measurements System

An apparatus for measuring lesion volume, for example, in laboratory animals, provides a mirror box allowing a camera to simultaneously acquire profiles of the lesion along at least two crossing axes ...
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Randall Kimple, Junzhou Chen, Hunter Higby, Ryan Wisth, Kyuhyun Lee, Jeremy Rogers | P190262US02

Technology

Blood-Brain Barrier Model

Accurately reproducing the blood-brain barrier in an in vitro setting has been a longstanding challenge. Current methods require the independent isolation of multiple cell types, and the quality of th...
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Eric Shusta, Clive Svendsen, Christian Weidenfeller | P06318US02

Technology

Dramatically More Sensitive Ion Channel Antenna

Nearly half of all diseases involve ion channels – channels in cell membranes that control the flow of ions into and out of cells. Certain channels open in response to natural signal molecules a...
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Robert Blick, Abhishek Bhat | P130074US01

Technology

Enhanced Blood-Brain Barrier Model Outperforms All Others

The blood-brain barrier (BBB) is made up of brain microvascular endothelial cells (BMECs), which line brain capillaries and control trafficking between the bloodstream and neural tissue. Although esse...
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Eric Shusta, Samira Azarin, Sean Palecek, Ethan Lippmann | P130017US02

Technology

Patch Clamp Providing On-Chip Thermal Control

Approximately half of all diseases affect the function of ion channels in cell membranes. Testing the flow of ions and molecules through these membranes clearly is vital to drug discovery and research...
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Robert Blick | P110325US01

Technology

Common Variants of the Sodium Channel Alpha Subunits

The SCN5A gene encodes a human cardiac sodium (Na+) channel alpha subunit that carries the inward Na+ current in the heart. Three distinct polymorphic SCN5A clones, hH1, hH1a and hH1b, have been isola...
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Jonathan Makielski, Bin Ye, Michael Ackerman | P02284US

Technology

Controllable Murine Models of First Pass Metabolism

The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
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Christopher Bradfield, Jacqueline Walisser, Tami Thomae | P04330US

Technology

HERG CDNA with Native PolyA Tail

The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
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Gail Robertson, Eugenia Jones, Blake Anson | P05401US

Technology

Stable Cell Lines Expressing hERG1a and 1b

Cardiac IKr channels are targets associated with inherited and acquired long QT syndrome (LQTS), a disorder that can lead to ventricular arrhythmias. Previously, IKr channels were thought to be compos...
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Gail Robertson, Eugenia Jones, Jinling Wang | P03380US

Technology

Human Heart Sodium Channel Beta1 Subunit (SCNB1)

The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
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Jonathan Makielski, Bin Ye | P03207US

WARF