Technologies
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WARF: P02004US

Endothelial Cells Derived from Human Embryonic Stem Cells


INVENTORS -

Dan Kaufman, Rachel Lewis, Robert Auerbach

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a simple and efficient method of inducing human embryonic stem cells to differentiate into endothelial cells.
OVERVIEWAlthough techniques exist for differentiating human embryonic stem cells (ES cells) into a number of specific cell types, no method currently exists for directing ES cell cultures to become endothelial cells, which line blood and lymphatic vessels and form capillaries.
THE INVENTIONUW-Madison researchers have developed a simple and efficient method of inducing human embryonic stem cells to differentiate into a relatively homogenous population of endothelial cells. The method involves culturing ES cells in a commercially available medium that supports the growth of endothelial cells. The resulting ES-derived endothelial cells have the general morphological characteristics and cell surface markers of endothelial cells. They are capable of inducing and participating in blood vessel formation when transplanted into tissue in vivo.
APPLICATIONS
  • Allows direct differentiation of ES cells into endothelial cells
  • May lead to new treatments for heart attack or stroke
  • Useful for studying the process of blood vessel formation
  • May lead to new targets for inhibiting blood vessel formation in tumor growth
KEY BENEFITS
  • Simple and efficient
  • Reproducible
  • Results in a relatively uniform population of endothelial cells
Contact Information
For current licensing status, please contact Andy DeTienne at adetienne@warf.org or 608-960-9857.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.