WARF: P00188US

Dual Resolution Acquisition of Magnetic Resonance Angiography Data with Vessel Segmentation


Charles Mistretta, Thomas Grist, Yousef Mazaheri Tehrani, Timothy Carroll, Jiang Du, Walter Block

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an improved vessel segmentation technique.
OVERVIEWMagnetic resonance angiography (MRA) is a type of magnetic resonance imaging (MRI) that generates images of blood flow through vessels. Its many medical applications include the diagnosis of artery and veins abnormalities, such as aneurysms in the brain.

To enhance MRA’s diagnostic capability, a contrast agent can be injected prior to the MRA scan; however, image data must be acquired at the moment the contrast agent is flowing through the vessels of interest. Thus, images must be taken very rapidly, severely limiting their resolution and quality.

UW–Madison researchers previously invented a vessel segmentation technique to improve the resolution and quality of contrast-enhanced MRA (CE-MRA) images. It entails capturing a series of low-resolution images when the contrast agent first flows through arteries and veins, and then using this information to pinpoint, or segment, the locations of arteries and veins in a high-resolution image acquired over a longer time period.
THE INVENTIONUW–Madison researchers have developed an improved vessel segmentation technique that involves two-dimensional correlation analysis, resulting in an MRA image of even higher spatial resolution and signal-to-noise ratio.
  • MR imaging of human vasculature
  • Unlike X-ray imaging methods—the current gold standard for studying human vasculature—this invention does not use an invasive catheter to inject the contrast agent
  • Will not subject the patient to potentially harmful ionizing radiation 
  • Projected to provide the same detail as an X-ray angiogram
  • CE-MRA technique with immense clinical utility
  • Provides a high resolution, high signal-to-noise ratio image of the human vasculature
  • Can be used with a number of different pulse sequences
  • Preferably uses a 3-D gradient recalled echo pulse sequence
Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
The WARF Advantage

Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.