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WiSys: T02017US

Anti-Anxiety Pharmaceuticals with Reduced Side Effects


INVENTORS -

James Cook, Qi Huang, Xiaohui He, Xiaoyan Li, Jianming Yu, Dongmei Han

OVERVIEWAccording to the National Institute of Mental Health, anxiety disorders affect approximately 40 million American adults. These chronic illnesses can severely decrease a patient’s quality of life. Anti-anxiety drugs, called anxiolytics, are used to treat central nervous system disorders, including anxiety disorders. The most frequently prescribed class of anxiolytics is benzodiazepines. This class of pharmaceuticals includes Valium, Xanax and others. These drugs reduce anxiety by binding to inhibitory neurotransmitters called gamma aminobutyric acid (GABA) type A receptors. However, benzodiazepines can cause significant side effects, including: drowsiness, dizziness, impaired memory, and decreased coordination. They can also lead to tolerance, dependence and abuse. There is a great and growing demand for new therapeutics providing relief for anxiety disorders without the debilitating side effects.
THE INVENTIONA team of researchers at UW-Milwaukee have developed novel benzodiazepine derivatives that offer increased binding sensitivity at GABA type A receptors while decreasing the negative side effects associated with these therapeutics. These orally-active derivatives, and salts thereof, provide enhanced anxiolytic activity with little or no sedative, hypnotic or muscle relaxing effects. These compounds were found to reduce situational anxiety in rats without causing significant sedation, muscle relaxation or ataxic effects. These benzodiazepine derivatives offer hope for more effective treatment of anxiety disorders in the future.
APPLICATIONS
  • More effective pharmaceutical treatment of anxiety disorders
KEY BENEFITS
  • Minimizes adverse side effects
  • Provides enhanced anxiolytic and anticonvulsant activity
  • Reduces sedative, hypnotic, muscle relaxant and ataxic effects
  • Can block pentylenetetrazole-induced seizures in rodents
STAGE OF DEVELOPMENTCompounds Isolated
Contact Information
For current licensing status, please contact Jennifer Souter at jennifer@wisys.org or (608) 316-4131.
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WiSys Technology Foundation serves the University of Wisconsin System comprehensive campuses by patenting and licensing discoveries to leading companies in Wisconsin, the United States and worldwide. Established in 2000 by the Wisconsin Alumni Research Foundation (WARF) and the UW System, WiSys is building the next generation of patent and licensing opportunities by fostering collaborations among campuses, private research organizations and industry, facilitating high-tech research with grant programs, and promoting student training for employment in a knowledge-based economy. WiSys's income is distributed to the UW campuses, the inventors and their departments to grow future discoveries and educational opportunities.